Apamin from bee venom suppresses inflammation in a murine model of gouty arthritis

Lee, Yun Mi; Cho, Soo-Na; Son, Eunjung; Song, Chang‐Hwa; Kim, Dong-Seon

doi:10.1016/j.jep.2020.112860

Cited by 30 publications

(27 citation statements)

References 22 publications

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“…Besides its effects on CNS, apamin is also known as an anti-inflammatory agent able to cause the inhibition of cyclooxygenase-2 and lower the levels of TNF-α, IL-1 (Interleukin-1), IL-6 and NO [37,80]. In this regard, another study showed that apamin was able to suppress Th2-related chemokines and other pro-inflammatory cytokines at the same time as inhibiting the activation of the NF-κB (Inhibitory effect of the nuclear factor kappa-B) and STAT pathways in human keratinocytes cell line [81].…”

Section: Apaminmentioning

confidence: 99%

“…Another important inflammatory disease is gouty arthritis. Gouty appears with the accumulation of monosodium urate crystals in the intra-articular space producing inflammation [37,138]. The intraperitoneal and oral administration of BV and apamin (0.5 and 1 mg/kg) not only showed a decrease in the inflammatory cytokines but also deceased the paw edema and pain in induced gouty mice.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

“…The intraperitoneal and oral administration of BV and apamin (0.5 and 1 mg/kg) not only showed a decrease in the inflammatory cytokines but also deceased the paw edema and pain in induced gouty mice. This could be a response to the lower inflammation produced by the suppression of NF-kB and NLRP3 inflammasome [37].…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

“…In vivo experiments have been almost always developed in mice, rats or murine models. For instance, recent studies have proved the positive effects of BV on amyotrophic lateral sclerosis [163], chronic prostatitis [164], gouty arthritis [37] or AD [144], among other diseases. Studies have also been developed on rabbits.…”

Section: Clinical Applicationsmentioning

confidence: 99%

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Bee Venom: An Updating Review of Its Bioactive Molecules and Its Health Applications

2020

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Bee venom (BV) is usually associated with pain since, when humans are stung by bees, local inflammation and even an allergic reaction can be produced. BV has been traditionally used in ancient medicine and in acupuncture. It consists of a mixture of substances, principally of proteins and peptides, including enzymes as well as other types of molecules in a very low concentration. Melittin and phospholipase A2 (PLA2) are the most abundant and studied compounds of BV. Literature of the main biological activities exerted by BV shows that most studies focuses on the comprehension and test of anti-inflammatory effects and its mechanisms of action. Other properties such as antioxidant, antimicrobial, neuroprotective or antitumor effects have also been assessed, both in vitro and in vivo. Moreover, human trials are necessary to confirm those clinical applications. However, notwithstanding the therapeutic potential of BV, there are certain problems regarding its safety and the possible appearance of adverse effects. On this perspective, new approaches have been developed to avoid these complications. This manuscript is aimed at reviewing the actual knowledge on BV components and its associated biological activities as well as the latest advances on this subject.

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Section: Apaminmentioning

confidence: 99%

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Section: Clinical Applicationsmentioning

confidence: 99%

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Bee Venom: An Updating Review of Its Bioactive Molecules and Its Health Applications

2020

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“…However, accumulating evidence also has highlighted the importance of apamin as a drug candidate [13]. Apamin has been shown to exert anti-inflammatory, antioxidative, and antiapoptotic activities in animal models of several inflammatory diseases, including gouty arthritis [14], multiple sclerosis [15], chronic liver disease [16], acute pancreatitis [17], and atherosclerosis [18]. However, no study has been conducted to evaluate whether apamin has a protective effect on LPS-induced AKI.…”

Section: Introductionmentioning

confidence: 99%

Antioxidative, Antiapoptotic, and Anti-Inflammatory Effects of Apamin in a Murine Model of Lipopolysaccharide-Induced Acute Kidney Injury

2020

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Sepsis is the major cause of acute kidney injury (AKI) in severely ill patients, but only limited therapeutic options are available. During sepsis, lipopolysaccharide (LPS), an endotoxin derived from bacteria, activates signaling cascades involved in inflammatory responses and tissue injury. Apamin is a component of bee venom and has been shown to exert antioxidative, antiapoptotic, and anti-inflammatory activities. However, the effect of apamin on LPS-induced AKI has not been elucidated. Here, we show that apamin treatment significantly ameliorated renal dysfunction and histological injury, especially tubular injury, in LPS-injected mice. Apamin also suppressed LPS-induced oxidative stress through modulating the expression of nicotinamide adenine dinucleotide phosphate oxidase 4 and heme oxygenase-1. Moreover, tubular cell apoptosis with caspase-3 activation in LPS-injected mice was significantly attenuated by apamin. Apamin also inhibited cytokine production and immune cell accumulation, suppressed toll-like receptor 4 pathway, and downregulated vascular adhesion molecules. Taken together, these results suggest that apamin ameliorates LPS-induced renal injury through inhibiting oxidative stress, apoptosis of tubular epithelial cells, and inflammation. Apamin might be a potential therapeutic option for septic AKI.

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Medicinal Benefits of Bee Venom

Sekar¹,

Lum²,

Bonam³

et al. 2023

Honey

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Apamin from bee venom suppresses inflammation in a murine model of gouty arthritis

Cited by 30 publications

References 22 publications

Bee Venom: An Updating Review of Its Bioactive Molecules and Its Health Applications

Bee Venom: An Updating Review of Its Bioactive Molecules and Its Health Applications

Antioxidative, Antiapoptotic, and Anti-Inflammatory Effects of Apamin in a Murine Model of Lipopolysaccharide-Induced Acute Kidney Injury

Medicinal Benefits of Bee Venom

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