APACHE scoring and prediction of survival in intensive care

Pilkington, Sally; McQuillan, P. J.; Smith, Gary B.; Taylor, Bruce L.

doi:10.1136/bmj.310.6988.1197b

Cited by 6 publications

(8 citation statements)

References 4 publications

(3 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3 A and Fig. S3 A; Table 1 and Table S5 ), similar to our recent report in other early-season variety, where IAD was lower in GA 3 -treated fruits compared with control fruits 17 . In the early-season variety Satohnishiki, GA 3 treatment decreased anthocyanin fruit content and modified the sugar accumulation pattern 13 .…”

Section: Discussionsupporting

confidence: 90%

“…Choi et al 14 reported that the mid-season varieties had a delayed increase in fruit size as well as polygalacturonase and Cx-cellulase activities after the GA 3 treatment, whereas GA 3 did not affect fruit growth in the early-season varieties. Kuhn et al 17 reported that the Index of Absorbance Difference (IAD), a ripening index, was delayed after the GA 3 treatment only in a mid-season variety, whereas the treatment reduced the IAD only at harvest in an early-season variety; interestingly, both varieties presented modified expression of ABA pathway-related genes. Despite the available information on the participation of GA in the fruit ripening process, the effect of this hormone has been barely explored at the whole gene expression level during the sweet cherry fruit ripening.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

RNAseq reveals different transcriptomic responses to GA3 in early and midseason varieties before ripening initiation in sweet cherry fruits

Kühn

Maldonado

Ponce

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Gibberellin (GA) negatively affects color evolution and other ripening-related processes in non-climacteric fruits. The bioactive GA, gibberellic acid (GA3), is commonly applied at the light green-to-straw yellow transition to increase firmness and delay ripening in sweet cherry (Prunus avium L.), though causing different effects depending on the variety. Recently, we reported that GA3 delayed the IAD parameter (a ripening index) in a mid-season variety, whereas GA3 did not delay IAD but reduced it at ripeness in an early-season variety. To further explore this contrasting behavior between varieties, we analyzed the transcriptomic responses to GA3 applied on two sweet cherry varieties with different maturity time phenotypes. At harvest, GA3 produced fruits with less color in both varieties. Similar to our previous report, GA3 delayed fruit color initiation and IAD only in the mid-season variety and reduced IAD at harvest only in the early-season variety. RNA-seq analysis of control- and GA3-treated fruits revealed that ripening-related categories were overrepresented in the early-season variety, including ‘photosynthesis’ and ‘auxin response’. GA3 also changed the expression of carotenoid and abscisic acid (ABA) biosynthetic genes in this variety. In contrast, overrepresented categories in the mid-season variety were mainly related to metabolic processes. In this variety, some PP2Cs putative genes were positively regulated by GA3, which are negative regulators of ABA responses, and MYB44-like genes (putative repressors of PP2Cs expression) were downregulated. These results show that GA3 differentially modulates the transcriptome at the onset of ripening in a variety-dependent manner and suggest that GA3 impairs ripening through the modification of ripening associated gene expression only in the early-season variety; whereas in the mid-season variety, control of the ripening timing may occur through the PP2C gene expression regulation. This work contributes to the understanding of the role of GA in non-climacteric fruit ripening.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

RNAseq reveals different transcriptomic responses to GA3 in early and midseason varieties before ripening initiation in sweet cherry fruits

Kühn

Maldonado

Ponce

et al. 2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…The provision of more high-dependency units has been proposed by many authors to minimize the number of preventable deaths after ICU discharge [12,24,25]. In this context the utilization of intermediate care units or the use of "hot zones" in the ward for patients not requiring a high level of care and the creation of "cold zones" in the ICU are important issues [2].…”

Section: Discussionmentioning

confidence: 99%

“…The lack of data is intriguing since it has been reported that mortality after ICU discharge is not negligible, ranging between 6% to 27% [11]. Recent data suggest that some of these post-ICU deaths are associated with inappropriately early ICU discharge and were therefore potentially preventable [12]. Furthermore, patients requiring readmission to the ICU have not only disproportionately high hospital mortality rates, ranging from 25% to 58% [13,14], but also prolonged ICU and hospital stay [15,16,17].…”

Section: Introductionmentioning

confidence: 99%

A nationwide survey of intensive care unit discharge practices

2005

View full text Add to dashboard Cite

“…Some doctors believe that no prognostic model derived from one population can be generalised to patients drawn from another,27 in the same way that some deny that clinical trials or overviews can inform individual decisions about treatment. We and others21 22 believe that model predictions cannot be safely applied to other patients unless…”

Section: Evidence Of Generalitymentioning

confidence: 99%