AP-1B regulates interactions of epithelial cells and intraepithelial lymphocytes in the intestine
Ryohtaroh Matsumoto,
Kosuke Ogata,
Daisuke Takahashi
et al.
Abstract:Intraepithelial lymphocytes (IELs) reside in the epithelial layer and protect against foreign pathogens, maintaining the epithelial barrier function in the intestine. Interactions between IEL and epithelial cells are required for IELs to function effectively; however, the underlying molecular machinery remains to be elucidated. In this study, we found that intestinal epithelium-specific deficiency of the clathrin adaptor protein (AP)-1B, which regulates basolateral protein sorting, led to a massive reduction i… Show more
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