AOT reverse micelles as versatile reaction media for chitosan nanoparticles synthesis

Orellano, María Soledad; Porporatto, Carina; Silber, Juana J.; Falcone, R. Darío; Correa, N. Mariano

doi:10.1016/j.carbpol.2017.04.074

Cited by 50 publications

(16 citation statements)

References 68 publications

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“…TA showed a wide characteristic peak in the range of 3200–3550 cm –1 , which can be attributed to the combined effect of the stretching vibration of the hydroxyl group and the intramolecular hydrogen bonding. [ 19,23 ] And this broad characteristic peak also displayed in CA‐TA NEs, TA‐ZA NPs, and CA‐TA‐ZA NSs, indicating the successful encapsulation of TA in these three delivery nanosystems. Besides, CA showed two characteristic peaks at 1624 and 1670 cm –1 , which belonged to CC double bond in the benzene ring and CO double bond, [ 16,24 ] respectively.…”

Section: Resultsmentioning

confidence: 89%

Green Regenerative Hydrogel Wound Dressing Functionalized by Natural Drug‐Food Homologous Small Molecule Self‐Assembled Nanospheres

Sun

Jia

Zhang

et al. 2021

Adv Funct Materials

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The goal of regenerative wound healing dressings is to restore tissue function back to normal physiological activity and accelerate skin tissue regeneration at wound sites. The optimal strategy to achieve this purpose requires a balance between material functionality, degradation, safety, and tissue regrowth. Herein, for the first time, an ultrasonic-triggered irreversible tending to equilibrium self-assembly and ionic cross-linking codriven strategy is proposed for producing multifunctional cinnamaldehyde-tannic acid-zinc acetate nanospheres (CA-TA-ZA NSs), realizing the fusion of hydrophilic and hydrophobic drug-food small molecules. Moreover, a novel "all-in-one" chitosan (CS)-based hydrogel functionalized by introducing drug-food small molecules self-assembled CA-TA-ZA NSs to the 3D network structures of CS is designed, integrating excellent antibacterial, antioxidant, anti-inflammatory and reducing oxidative stress damage abilities. Additionally, the multifunctional CS-based hydrogel can realize rapid in situ gelation at wound sites and completely cover the irregular wounds. All of these superiorities enable the CS-based hydrogel to clean the wound microenvironment, induce skin tissue remodeling, promote blood vessel repair and hair follicle regeneration, restore the immune system back to normal physiological activity, and accelerate wound healing. Therefore, this study offers a new perspective for the design of advanced functional materials with great application potential in the biomedical field.

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Section: Resultsmentioning

confidence: 89%

Green Regenerative Hydrogel Wound Dressing Functionalized by Natural Drug‐Food Homologous Small Molecule Self‐Assembled Nanospheres

Sun

Jia

Zhang

et al. 2021

Adv Funct Materials

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“…La microscopia confocal indicó que una mayor proporción de antígenos estuvieron concentrados en la superficie de las nanopartículas y que éstos presentaban la capacidad de inducir la formación de anticuerpos específicos. Orellano et al (2017) obtuvieron nanopartículas de quitosano entrecruzadas con glutaraldehído utilizando micelización inversa, partiendo de una solución de AOT en nheptano. Las nanopartículas obtenidas presentaron bajos niveles de polidispersidad y su tamaño dependió en gran…”

Section: Micelización Inversaunclassified

Métodos de preparación de nanopartículas de quitosano: una revisión

et al. 2019

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El quitosano es un polisacárido natural que ha sido utilizado frecuentemente en el desarrollo de distintos materiales, debido a sus excepcionales propiedades fisicoquímicas y biológicas. Las nanopartículas de quitosano son generalmente producidas por estrategias denominadas de construcción (del inglés “bottom up”), donde el ensamblado polimérico es promovido por distintas interacciones moleculares. Sin embargo, un grupo de estrategias llamadas de deconstrucción (del inglés “top-down”) basadas en la fragmentación de estructuras macroscópicas, han generado un gran interés recientemente como alternativa para la obtención de nanomateriales. El presente trabajo hace una revisión bibliográfica de los resultados obtenidos por distintas investigaciones sobre la producción de sistemas de nanopartículas basadas en quitosano durante las últimas décadas. Las evidencias demostraron que las nanopartículas de quitosano juegan un papel preponderante en la investigación de los nanomateriales poliméricos con aplicaciones biomédicas y farmacéuticas, debido a la gran diversidad de métodos de obtención existentes que determinan las propiedades de los materiales, tales como tamaño de partícula, capacidad de incorporación y liberación de compuestos bioactivos, carga superficial, mucoadhesividad, entre otras.

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“…Reverse micelles (RMs) are supramolecular aggregates formed by surfactant molecules dispersed in nonpolar solvents. RMs are organized so that the surfactant head groups point inward to the center containing the polar solvent and the hydrophobic tails extend outward into the organic nonpolar continuous phase, allowing them to encapsulate water or other polar solvents in their polar heart. , Taking into account their conformation, RMs have shown a wide array of applications, which include their use as mimetic agents, in cell biomembrane modeling, in drug delivery, in oil recovery enzymology, and as “nanoreactors” for organic molecules and nanoparticles synthesis. − …”

Section: Introductionmentioning

confidence: 99%

Catanionic Reverse Micelles as an Optimal Microenvironment To Alter the Water Electron Donor Capacity in a S_N2 Reaction

et al. 2019

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The effect of interfacial water entrapped in two types of catanionic reverse micelles (RMs) on the kinetic parameters of the S N 2 reaction between dimethyl-4-nitrophenylsulfonium trifluoromethanesulfonate (S +) and n-butylamine (BuNH 2) was explored. Two catanionic surfactants, composed of a mixture of oppositely charged ionic surfactants without their original counterions, were used to create the RMs. Thus, benzyl-n-hexadecyldimethylammonium 1,4-bis(2-ethylhexyl) sulfosuccinate (BHD-AOT) and cetyltrimethylammonium 1,4-bis(2-ethylhexyl) sulfosuccinate (CTA-AOT) were formed. Also, the wellknown anionic surfactant sodium 1,4-bis(2-ethylhexyl) sulfosuccinate (Na-AOT) was employed as a comparison. Our results showed an important catalytic-like effect of all RMs investigated in comparison with a water−benzene mixture, and the rate constant values depend on the type of surfactant used. Faster reaction in BHD-AOT RMs than in CTA-AOT and Na-AOT RMs was observed. This behavior was attributed to the strong interaction (by hydrogen bonding with AOT anion and ion-dipole interaction with BHD +) between the entrapped water and the BHD-AOT interface, which reduces the solvation capacity of water on S +. In CTA-AOT (and Na-AOT) RMs, the water−interface interaction is weaker and the electron pairs of water can solvate S + ions. In summary, the chemical structure of the counterion on the catanionic surfactant alters the interfacial region, allowing the progress of a reaction inside the RMs to be controlled.

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AOT reverse micelles as versatile reaction media for chitosan nanoparticles synthesis

Cited by 50 publications

References 68 publications

Green Regenerative Hydrogel Wound Dressing Functionalized by Natural Drug‐Food Homologous Small Molecule Self‐Assembled Nanospheres

Green Regenerative Hydrogel Wound Dressing Functionalized by Natural Drug‐Food Homologous Small Molecule Self‐Assembled Nanospheres

Métodos de preparación de nanopartículas de quitosano: una revisión

Catanionic Reverse Micelles as an Optimal Microenvironment To Alter the Water Electron Donor Capacity in a S_N2 Reaction

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AOT reverse micelles as versatile reaction media for chitosan nanoparticles synthesis

Cited by 50 publications

References 68 publications

Green Regenerative Hydrogel Wound Dressing Functionalized by Natural Drug‐Food Homologous Small Molecule Self‐Assembled Nanospheres

Green Regenerative Hydrogel Wound Dressing Functionalized by Natural Drug‐Food Homologous Small Molecule Self‐Assembled Nanospheres

Métodos de preparación de nanopartículas de quitosano: una revisión

Catanionic Reverse Micelles as an Optimal Microenvironment To Alter the Water Electron Donor Capacity in a SN2 Reaction

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Catanionic Reverse Micelles as an Optimal Microenvironment To Alter the Water Electron Donor Capacity in a S_N2 Reaction