Aortitis caused by antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis: a case-based review

Skeik, Nedaa; Hari, Gopika; Nasr, Rawad

doi:10.1007/s00296-019-04343-3

Cited by 13 publications

(16 citation statements)

References 31 publications

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“…Skeik N et al report ten cases of aortitis related to AAV, in addition to their case report, and suggested using rituximab for treatment [27]. By studying 16 consecutive patients with periaortitis diagnosed by CT scanning, Vaglio et al identified three cases with positive ANCAs including one with crescentic necrotizing glomerulonephritis [28].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of large vessel vasculitis in ANCA-associated vasculitis: a retrospective cohort study

et al. 2021

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ANCA-associated vasculitis (AAV) in general involves small blood vessels and includes granulomatosis with polyangiitis (GPA), eosinophilic granulomatosis with polyangiitis (EGPA), and microscopic polyangiitis (MPA). Although reported in a few studies, the prevalence of large vessel vasculitis (LVV) in patients with AAV remains to be further explored. The goal of the present study was to assess the prevalence of LVV in a cohort of patients with AAV and to characterize this population. We conducted a ten-year retrospective study of a single-center cohort of AAV, including 101 patients with GPA (n = 58), EGPA (n = 28), MPA (n = 15), and compared the groups with or without associated LVV. LVV was diagnosed in five patients, two with aortitis and three with temporal arteritis, corresponding to a total prevalence of 5.0% [95% CI 1.6–11.2%]. This value was significantly higher than the estimated prevalence of LVV in the normal Swiss population (OR 234.9 95% CI 91.18–605.2, p < 0.001). All five patients had GPA, whereas no cases with EGPA or MPA were identified. Anti-PR3 antibodies were detected in four out of five patients, anti-MPO in one patient. Since LVV can occur in a significant proportion of patients with GPA, evaluation for LVV may be considered systematically in the diagnostic workup of AAV.

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Section: Discussionmentioning

confidence: 99%

Prevalence of large vessel vasculitis in ANCA-associated vasculitis: a retrospective cohort study

et al. 2021

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“…Although there have been some cases of EGPA in which a coronary artery aneurysm developed, there has been no report of aortic involvement [3,4]. Contrarily, aortic involvement has been reported in patients with MPA and GPA [5][6][7][8]. Of note, GPA-related aortic involvement has presented as aortic wall inflammation, histologically [5].…”

Section: Discussionmentioning

confidence: 99%

“…Type B aortic dissection can generally be managed conservatively by long-term blood pressure and imaging surveillance [2]. Most patients with aortic involvement accompanied by MPA and GPA have undergone endovascular or surgical interventions [5,7,8]; however, Skeik and colleagues advocated the effectiveness of immunosuppressants for aortitis caused by ANCA-associated vasculitis [6].…”

Section: Discussionmentioning

confidence: 99%

Aortic Dissection due to Eosinophilic Granulomatosis With Polyangiitis

Ito

2020

Cureus

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Eosinophilic granulomatosis with polyangiitis (EGPA) usually presents as a systemic vasculitis of small-and middle-sized blood vessels. There has been no report of this disorder accompanying aortic involvement. A 61-year-old woman with EGPA was admitted to the hospital because of type B aortic dissection. She was treated medically, and the lesion did not worsen during her hospitalization. EGPA can present as aortic involvement, and conservative treatment is useful in managing this condition. Clinicians should be aware of the possibility of aortic involvement in patients with EGPA who have sudden back pain.

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“…To authors' knowledge, this is the first description of a confirmed p-ANCA-associated aortitis documented with CEUS, SMI and MR. Until 2019 merely ten cases of aortic involvement in ANCA-associated vasculitis (AAV) were reported in the literature. AAV is a necrotizing inflammation primarily affecting small vessels, thus presenting as multi-organ disease [2]. Large vessels are rarely affected and the pathomechanism resembles small-vessel disease.…”

Section: Conflict Of Interest: None Declaredmentioning

confidence: 99%

A rare case of aortic involvement in microscopic polyangiitis evaluated in contrast-enhanced ultrasound, superb microvascular imaging and magnetic resonance

Drelich-Zbroja¹,

Kuczyńska²,

Majdan³

et al. 2022

Polish Archives of Internal Medicine

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Aortitis caused by antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis: a case-based review

Cited by 13 publications

References 31 publications

Prevalence of large vessel vasculitis in ANCA-associated vasculitis: a retrospective cohort study

Prevalence of large vessel vasculitis in ANCA-associated vasculitis: a retrospective cohort study

Aortic Dissection due to Eosinophilic Granulomatosis With Polyangiitis

A rare case of aortic involvement in microscopic polyangiitis evaluated in contrast-enhanced ultrasound, superb microvascular imaging and magnetic resonance

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