Aortic valve sclerosis as a marker of coronary artery atherosclerosis; a multicenter study of a large population with a low prevalence of coronary artery disease

Rossi, Andrea; Gaibazzi, Nicola; Dandale, Raje; Agricola, Eustachio; Moreo, Antonella; Berlinghieri, Nicola; Sartorio, Daniele; Loffi, Marco; Chiara, Benedetta De; Rigo, Fausto; Vassanelli, C.; Faggiano, Pompilio

doi:10.1016/j.ijcard.2014.01.024

Cited by 29 publications

(23 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many studies showed that there is an important relation between the SS and undesired cardiac outcomes (8,16,17). To date, there are a few studies investigating the relation between the SS and AVS (2,9,15,18). In these studies, ACS cases were included and the relation of the SS with AVS was investigated.…”

Section: Discussionmentioning

confidence: 99%

Aortic valve sclerosis is associated with the extent of coronaryartery disease in stable coronary artery disease

et al. 2017

View full text Add to dashboard Cite

IntroductionAortic valve sclerosis (AVS) is defined as increased thickness and progressive calcification of aortic valves that causes no obstruction to ventricular output (antegrade velocity across the valve of less than 2.5 m/s) (1). Histopathological studies demonstrated that causes of AVS are the accumulation of atherogenic lipoproteins, inflammatory cell infiltration, and microscopic calcification in the extracellular matrix (2-4). An independent relation was revealed between atherosclerosis risk factors and clinical cardiovascular disease and AVS. This relation implies that AVS and coronary artery disease (CAD) may have a similar mechanism of formation (5).The Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score (SS) is an angiographic method for grading the complexity and intensity of CAD and provides more comprehen-sive evaluation of properties of the coronary lesion (6-8). Some previous studies showed that a significant correlation between the SS and AVS was revealed in patients with acute coronary syndrome (9). In our study, we investigated the correlation between the SS and AVS by including both ACS and stable CAD cases. Materials and methodsWe enrolled 543 patients with CAD (stable CAD and acute coronary syndrome without ST segment elevation) who underwent coronary angiography in this cross-sectional study between September 2013 and September 2014. The institutional ethics committee approved the study. Patients with persistent ST segment elevation (n = 370), history of percutaneous coronary intervention (n = 190) or coronary artery bypass grafting (n = 77), rheumatic heart valve disease (n = 23), bicuspid aortic valve (n = 14), aortic valvular Background/aim: Aortic valve sclerosis (AVS) is characterized by lipid deposition and calcific infiltration on the edge of aortic leaflets without significant restriction of motion. The SYNTAX Score (SS) is an important method for evaluating coronary artery disease (CAD). Many studies showed that there is an important relation between the SS and undesired cardiac outcomes. In our study, we investigated the correlation between the SS and AVS by including both ACS and stable CAD cases. Materials and methods:We enrolled 543 patients with CAD who underwent coronary angiography into this cross-sectional study between September 2013 and September 2014. Results:The study population was divided into two groups according to SS values above and below 22. Diabetes mellitus (DM) incidence was greater in the group with high SS values (26.3% vs. 19.2%, P = 0.052.). Left ventricular ejection fraction (LVEF) and glomerular filtration rate were lower. Low-density lipoprotein cholesterol and triglyceride levels were lower while platelet counts were higher. In multivariate analysis, for the stable coronary artery group AVS existence, platelet count, LVEF value, and chronic obstructive pulmonary disease were found as independent predictors. Conclusion:Our study results demonstrated that AVS is significantly associated with the complexity o...

show abstract

Section: Discussionmentioning

confidence: 99%

Aortic valve sclerosis is associated with the extent of coronaryartery disease in stable coronary artery disease

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Previous study indicated that the morbidity and mortality of CHD are very high [1]. CHD was a complex polygenic disease resulting from the interaction between genetic variations and environmental factors [2].…”

Section: Introductionmentioning

confidence: 99%

CYP4F2 genetic polymorphisms are associated with coronary heart disease in a Chinese population

Yan

et al. 2014

Lipids Health Dis

View full text Add to dashboard Cite

BackgroundTo explore the relationship between CYP4F2 gene polymorphism and coronary heart disease (CHD) in a Chinese Han population.MethodsWe selected 440 CHD patients and 440 control subjects to perform a case - control study. Four SNPs (rs2108622, rs3093100, rs3093105 and rs3093135) in CYP4F2 gene were genotyped using polymerase chain reaction - restriction fragment length polymorphism (PCR - RFLP) methods. The genotype and haplotype distributions were compared between the case and the control group.ResultsWe found both rs2108622 and rs3093105 in CYP4F2 gene were associated with the risk for CHD (P <0.01). Haplotype analysis indicated that GGGT haplotype consisted by rs2108622-rs3093100-rs3093105-rs3093135 was associated with CHD risk (OR = 4.367, 95% CI: 2.241 ~ 8.510; P < 0.001), but GGTA haplotype was associated with decreased risk for CHD (OR = 0.450, 95% CI: 0.111 ~ 0.777; P <0.001).ConclusionCYP4F2 gene polymorphisms were associated with the risk of CHD in Chinese population.

show abstract

“…Over the past decade, there has been accumulating evidence that extracoronary thoracic calcifications such as calcifications of the aortic valve (7)(8)(9)(10), thoracic aorta, and mitral valve/ annulus also seem to correlate with coronary calcified plaque burden (11), CHD (12), all-cause, and cardiovascular mortality (13)(14)(15).…”

mentioning

confidence: 99%

Extracoronary Thoracic and Coronary Artery Calcifications on Chest CT for Lung Cancer Screening

et al. 2015

View full text Add to dashboard Cite

Aortic valve sclerosis as a marker of coronary artery atherosclerosis; a multicenter study of a large population with a low prevalence of coronary artery disease

Cited by 29 publications

References 25 publications

Aortic valve sclerosis is associated with the extent of coronaryartery disease in stable coronary artery disease

Aortic valve sclerosis is associated with the extent of coronaryartery disease in stable coronary artery disease

CYP4F2 genetic polymorphisms are associated with coronary heart disease in a Chinese population

Extracoronary Thoracic and Coronary Artery Calcifications on Chest CT for Lung Cancer Screening

Contact Info

Product

Resources

About