Aortic Valve Replacement

Dominik, Jan; Žáček, Pavel; Vojacek, Jan

doi:10.1007/978-3-319-74213-7_14

Cited by 1 publication

(1 citation statement)

References 121 publications

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“…Nevertheless, the production of a hybrid composite part, consisting of a fragile metal insert and an ultra-thin-walled polymer cover, is still a challenge, especially given the small dimensions and tolerances of heart valve components. This requires full knowledge of the rheological properties of the polymer (TPU—Thermoplastic Polyurethane) [ 18 , 19 , 20 , 21 , 22 ], simulation methods exceeding the current state-of-the-art practices, precise positioning of the metal frame, and an adapted micro-injection molding cycle to avoid any collapsing of the frame due to the high pressure of the melt during filling in of the cavity [ 9 , 10 , 23 , 24 , 25 , 26 , 27 ]. Additionally, some aspects of heart-valve sealing to prevent wear of the TPU leaflet can be challenging.…”

Section: Introductionmentioning

confidence: 99%

Hemocompatibile Thin Films Assessed under Blood Flow Shear Forces

et al. 2022

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The aim of this study was to minimize the risk of life-threatening thromboembolism in the ventricle through the use of a new biomimetic heart valve based on metal–polymer composites. Finite volume element simulations of blood adhesion to the material were carried out, encompassing radial flow and the cone and plane test together with determination of the effect of boundary conditions. Both tilt-disc and bicuspid valves do not have optimized blood flow due to their design based on rigid valve materials (leaflet made of pyrolytic carbon). The main objective was the development of materials with specific properties dedicated to contact with blood. Materials were evaluated by dynamic tests using blood, concentrates, and whole human blood. Hemostability tests under hydrodynamic conditions were related to the mechanical properties of thin-film materials obtained from tribological tests. The quality of the coatings was high enough to avoid damage to the coating even as they were exposed up to maximum loading. Analysis towards blood concentrates of the hydrogenated carbon sample and the nitrogen-doped hydrogenated carbon sample revealed that the interaction of the coating with erythrocytes was the strongest. Hemocompatibility evaluation under hydrodynamic conditions confirmed very good properties of the developed coatings.

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