Aortic Valve Replacement in Octogenarians—Do Outcomes Justify the Practice?

Abstract

S Heart, Lung and CirculationAbstracts S223 2011;20S:S156-S251 up and echo. Diagnosis of MFS by Ghent criteria. Bicuspid aortic valve (BAV) diagnosed by echo. Mean follow-up was 10 ± 8 years.Results: Patients with non-MFS TAAD presented later but had similar severity of aortic dilation. Major adverse cardiac events (MACE = dissection, surgery or death) were similar in MFS and non-MFS TAAD but first MACE occurred at younger age in MFS. Death rates and age of death were comparable between MFS and non-MFS TAAD. MFS+ve BAV +ve MFS/BAV −ve p Number 176 53 153 Age enrolled Yrs 24.6 ± 13.9 42.8 ± 15.5 43.4 ± 18.3 <0.01 Ao diameter mm/m 2 28.6 ± 3.4 22.3 ± 4.3 29.3 ± 2.7 Family history % 62 21 53 MACE % 39 53 44 Age MACE Yrs 32.8 ± 12.5 47.4 ± 13.2 49.1 ± 16.7 <0.01 Deaths % 12 6 9 Age death Yrs 51.2 ± 10.7 54 ± 7.8 56.8 ± 13.7Conclusions: Non-MFS TAAD presents later but has adverse outcomes similar to MFS, although MACE occur later in non-MFS TAAD. Family history is common. Screening of first-degree relatives and active surveillance and intervention are warranted as per patients with MFS.