Aortic Valve Replacement for Aortic Regurgitation in a Patient With Primary Antiphospholipid Syndrome

Matsuyama, Katsuhiko; Ueda, Yuichi; Ogino, Hitoshi; Sugita, Tadaaki; Matsubayashi, Keiji; Nomoto, Takuya; Yoshimura, S.; Yoshioka, Takayuki

doi:10.1253/jcj.63.725

Cited by 11 publications

(5 citation statements)

References 7 publications

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“…Although high titers of anticardiolipin β 2 -glycoprotein IgG antibody were recorded fi ve times, they were lower than in previous operative reports; [4][5][6] and preoperative serum levels were within the normal range. One possible reason for this result is the prednisolone administered to treat the underlying SLE.…”

Section: Discussioncontrasting

confidence: 66%

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Aortic valve replacement for aortic regurgitation in a patient with antiphospholipid antibody syndrome

Sasahashi

Harada

Saji

et al. 2007

Gen Thorac Cardiovasc Surg

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Cardiac manifestations of antiphospholipid antibody syndrome (APLS) comprise a major complication. Herein we report our surgical treatment of aortic regurgitation in a patient with APLS. A 61-year-old woman was referred to our hospital with symptoms of congestive heart failure. Systemic lupus erythematosus had been diagnosed at the age of 36, and immunosuppressive therapy has been continuously performed. APLS was also diagnosed at the age of 55, after which cardiomegaly was noted on chest radiographs and aortic regurgitation was evident on echocardiography. Although immunosuppressive therapy had been continued, cardiac symptoms began to develop. With a presumed diagnosis of valvular disease associated with autoimmune disease, the aortic valve was replaced with a bioprosthesis. Noninfective endocarditis was confirmed in the excised specimen and was likely involved in APLS. The patient was discharged on postoperative day 26 without complications.

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Section: Discussioncontrasting

confidence: 66%

“…2 There have been only four surgical reports of aortic valvular lesions in Japanese patient with APLS (Table 1). 4,5,9 All patients were women aged 32-61 years who had regurgitant disorders. APLS was thought to be secondary to SLE in two patients, including ours, and primary in two patients.…”

Section: Discussionmentioning

confidence: 99%

Aortic valve replacement for aortic regurgitation in a patient with antiphospholipid antibody syndrome

Sasahashi

Harada

Saji

et al. 2007

Gen Thorac Cardiovasc Surg

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“…In most of these cases, the follow-up was not reported. [6][7][8][9][10][11][12][13][14][15][16][17][18][19] The high mortality and the increased morbidity observed in our experience may be accounted for by several factors. These include comorbid states and the consequences of treatment of these conditions and the advanced nature of the valvular heart disease at the time of surgical intervention.…”

Section: Discussionmentioning

confidence: 99%

“…We do not have evidence as yet for such. Replacement with a mechanical valve may also min- MVR 0/1 Not available Hogan 10 AVR 0/1 Uneventful, 1.4 year Galve 11 MVR 1/1 Operative death Kato 12 MVR 0/1 CNS thrombosis, re-MVR at 9 years Matsuyama 13 AVR 0/1 Not available Myers 14 AVRϩMVR 0/1 Not available Noji 15 MVR 0/1 Uneventful, 4 years Sakagushi 16 AVR 0/1 Uneventful, 1 year Schumacher 17 MVR 0/1 Re-MVR 0.75 year Erkan 18 MVR, MVRϩAVR 0/2 Not available East 19 MVR 0/2 Not available imize the need for repeat, high-risk operations. As discussed earlier, the impaired immunity incurred by the disease and the immunosuppressive treatment may complicate the postoperative course.…”

Section: Discussionmentioning

confidence: 99%

Increased morbidity and mortality in patients with antiphospholipid syndrome undergoing valve replacement surgery

Berkun

Elami

Meir

et al. 2004

The Journal of Thoracic and Cardiovascular Surgery

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“…The most frequent valvular pathology includes an irregular thickening of the valve leafl ets from the deposition of immune complexes. This process can affect both the mitral and aortic valves (4,5) .…”

Section: Introductionmentioning

confidence: 99%

Successful Replacement of Mitral Valve in a Patient with Antiphospholipid Syndrome

Gürkan¹,

Gür²,

Gür³

et al. 2016

Kosuyolu Heart Journal

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We report a 51-year-old patient who was diagnosed with mitral insuffi ciency and was admitted to our hospital for surgical treatment. The patient was diagnosed with primary antiphospholipid syndrome (PAPS) before 4 years and had a history of thrombocytopenia. Mitral valve replacement was successfully performed with postoperative strict anticoagulant therapy, and the postoperative course was uneventful. Cardiac surgery in APS patients has been associated with high morbidity and mortality. Therefore, it is very important to initiate anticoagulant therapy immediately after the operation to prevent thrombosis. ÖZETElli bir yaşında mitral yetmezlik tanısı ile cerrahi tedavi için yatırılan bir hastayı sunduk. Dört yıl önce primer antifosfolipid tanısı almış ve trombositopeni hikayesi mevcut. Postoperatif titiz antikoagülan tedavi ile mitral kapak başarılı bir şekilde replase edildi ve postoperatif dönem olaysız geçti. Antifosfolipid sendromlu hastalarda kardiyak cerrahide yüksek mortalite ve morbidite oranları bildirilmiştir. Postoperatif dönemde hemen antikoagülan tedavinin başlanması trombozun önlenmesi açısından çok önemlidir. Anahtar Kelimeler: Antifosfolipid sendromu; mitral kapak; trombositopeniThe blood laboratory results were as follows: hemoglobin, 12.9 g/dL; hematocrit, 40.2%; platelet, 53.000/mm 3 ; prothrombin time, 11.8 s; international normalized ratio (INR), 1.08;

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Aortic Valve Replacement for Aortic Regurgitation in a Patient With Primary Antiphospholipid Syndrome

Cited by 11 publications

References 7 publications

Aortic valve replacement for aortic regurgitation in a patient with antiphospholipid antibody syndrome

Aortic valve replacement for aortic regurgitation in a patient with antiphospholipid antibody syndrome

Increased morbidity and mortality in patients with antiphospholipid syndrome undergoing valve replacement surgery

Successful Replacement of Mitral Valve in a Patient with Antiphospholipid Syndrome

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