Aortic Valve Prolapse and Aortic Regurgitation in Patients with Ventricular Septal Defect

Eroğlu, Ayşe Güler; Öztunç, Funda; Saltık, Levent; Dedeoğlu, Selin Ece; Bakari, Süleyman; Ahunbay, Gülay

doi:10.1007/s00246-002-1423-6

Cited by 33 publications

(28 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent evidence suggests that the progression from mild to severe incompetence may be rapid and that surgical intervention should be early. 15 Echocardiography with colour flow mapping is an effective technique for the detection of VSD 16 and in fact is more sensitive than cardiac catheterisation in the detection of multiple septal defects. 8 Echocardiography has also been shown to be as sensitive as cardiac catheterisation in the detection of other cardiac abnormalities, such as infundibular pulmonary stenosis.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and development of additional cardiac abnormalities in 1448 patients with congenital ventricular septal defects

Glen

2004

Heart

View full text Add to dashboard Cite

Objective: To determine by modern echocardiographic techniques the prevalence and development of cardiac abnormalities associated with ventricular septal defect (VSD). Methods: Consecutive patients referred to a tertiary centre for paediatric cardiology and attenders at an adult congenital heart disease clinic had details of clinical outcome prospectively recorded. Patients with VSD in association with conotruncal abnormalities, atrioventricular septal defects, and univentricular heart were not included in the study. Results: 1448 patients with VSD were assessed between 1991 and 1998. 1127 (78%) patients had isolated defects; of these 862 (76%) were perimembranous and 265 (24%) were muscular. Of the remainder, 284 (19.6% of the total population) patients had VSD associated with one other significant cardiac abnormality: 35 (2.4%) with two and two (0.1%) with three other abnormalities. The most common associated cardiac abnormalities were infundibular pulmonary stenosis (5.8%), aortic valve prolapse (3.6%), pulmonary valvar stenosis (2.7%), osteum secundum atrial septal defect (2.2%), persistent ductus arteriosus (1.9%), and coarctation of the aorta (1.5%). In the cohort of 743 patients followed up from birth, cumulative mortality was 4% by the age of 8 years and most deaths occurred within the first year of life in infants with associated genetic abnormalities such as trisomy 13 or 18. Of the 594 patients attending the adult congenital clinic with VSD, aortic regurgitation due to aortic root prolapse developed in 45 (7.6%) patients. Most of these cases were detected before the patient was 30 years old. Conclusions: In 22% of patients with congenital VSD there were significant associated cardiac abnormalities. Some of these abnormalities, such as aortic prolapse and regurgitation or infundibular pulmonary stenosis, may develop or progress subsequently and therefore should be sought during the initial assessment and monitored during follow up. Follow up to the age of 30 years allows the detection of most cases of aortic regurgitation. The prognosis from VSD is excellent and the risk of endocarditis in a population informed of the need for antibiotic prophylaxis is small.

show abstract

Section: Discussionmentioning

confidence: 99%

Prevalence and development of additional cardiac abnormalities in 1448 patients with congenital ventricular septal defects

Glen

2004

Heart

View full text Add to dashboard Cite

show abstract

“…[1234] This includes all the perimembranous and doubly committed juxta-arterial defects and outlet muscular VSD. While the right coronary cusp (RCC) is usually involved in case of AV prolapse with VSD, the noncoronary cusp is less frequently affected.…”

Section: Introductionmentioning

confidence: 99%

Predictors for the outcome of aortic regurgitation after cardiac surgery in patients with ventricular septal defect and aortic cusp prolapse in Saudi patients

et al. 2016

View full text Add to dashboard Cite

Background and Aim:Aortic valve (AV) prolapse and subsequent aortic regurgitation (AR) are two complications of ventricular septal defects (VSD) that are located close to or in direct contact with the AV. This finding is one of the indications for surgical VSD closure even in the absence of symptoms to protect the AV integrity. The goal of our study was to assess the outcome and to identify the predictors for improvement or progression of AR after surgical repair.Materials and Methods:A retrospective study of all children with VSD and AV prolapse who underwent cardiac surgery at King Abdulaziz Cardiac Centre in Riyadh between July 1999 and August 2013.Results:A total of 41 consecutive patients, operated for VSD with prolapsed AV, with or without AR, were reviewed. The incidence of AV prolapse in the study population was 6.8% out of 655 patients with VSD. Thirty-six (88%) patients had a perimembranous VSD, and four had doubly committed VSD. Only one patient had an outlet muscular VSD. Right coronary cusp prolapse was found in 38 (92.7%) patients. Preoperative AR was absent in five patients, mild or less in 25 patients, moderate in seven, and severe in four patients. Twenty-six patients showed improvement in the degree of AR after surgery (Group A), 14 patients showed no change in the degree of AR (Group B) while only one patient showed the progression of his AR after surgery. Those with absent AR before surgery remained with no AR after surgery. Improvement was found more in those with mild degree of AR preoperatively compared to those with moderate and severe AR. Female gender also showed a tendency to improve more as compared to male.Conclusion:Early surgical closure is advisable for patients with VSD and associated AV prolapse to achieve a better outcome after repair and to prevent progression of AR in future.

show abstract

“…According to previous studies, the incidence of AVP associated with ventricular septal defects was between 7.5% and 52.7%. AR was found in 4.8% to 14% of patients with AVP [1,5].…”

Section: Discussionmentioning

confidence: 98%

In situ patch closure of ventricular septal defect with aortic regurgitation

Büyükbayrak¹,

Aksoy²,

Taş³

et al. 2013

kitp

View full text Add to dashboard Cite

Aortic valve prolapse (AVP) in patients with a ventricular septal defect (VSD) is known to be caused by high gradient flow through the defect. In adult patients, VSD may lead to AVP and subsequent aortic regurgitation (AR). Although aortic valvuloplasty and the concurrent closure of the defect is the therapy of choice for children, it carries a high risk of reoperation in adults. We present a case of a 20-year-old male with perimembranous outlet type VSD and severe AR. During the operation, the non-coronary cusp was inverted towards the defect and used as an in situ patch. The severely deformed coronary cusps were excised and the aortic valve was replaced.

show abstract

Aortic Valve Prolapse and Aortic Regurgitation in Patients with Ventricular Septal Defect

Cited by 33 publications

References 16 publications

Prevalence and development of additional cardiac abnormalities in 1448 patients with congenital ventricular septal defects

Prevalence and development of additional cardiac abnormalities in 1448 patients with congenital ventricular septal defects

Predictors for the outcome of aortic regurgitation after cardiac surgery in patients with ventricular septal defect and aortic cusp prolapse in Saudi patients

In situ patch closure of ventricular septal defect with aortic regurgitation

Contact Info

Product

Resources

About