Aortic valve microcalcification and cardiovascular risk: an exploratory study using sodium fluoride in high cardiovascular risk patients

Domingues, C; Ferreira, Maria João; Silva, Rodolfo; Oliveira-Santos, Manuel; Gomes, Álvaro; Chichorro, Nuno; Lima, João Pedroso de; Gonçalves, Lino; Abrunhosa, Antero

doi:10.1007/s10554-020-01854-0

Int J Cardiovasc Imaging

2020

DOI: 10.1007/s10554-020-01854-0

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Aortic valve microcalcification and cardiovascular risk: an exploratory study using sodium fluoride in high cardiovascular risk patients

C Domingues

Maria João Ferreira

Rodolfo Silva

et al.

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Cited by 3 publications

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“… 6 , 7 , 8 , 9 , 10 Cardiac positron emission tomography (PET) may help evaluate patients with AS. 11 The myocardial blood flow (MBF) and myocardial flow reserve (MFR) quantified in PET myocardial perfusion imaging (MPI) have shown a distinct and incremental prognostic value in patients with potential or confirmed coronary artery disease. 12 , 13 Limited understanding of the AS disease process, including coronary artery disease and ventricular dysfunction in the context of AS, hinders the development of effective medical therapies to slow or halt disease progression.…”

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confidence: 99%

Myocardial Blood Flow Reserve, Microvascular Coronary Health, and Myocardial Remodeling in Patients With Aortic Stenosis

Alahdab,

Ahmed,

Nayfeh

et al. 2024

JAHA

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Background Coronary microvascular function and hemodynamics may play a role in coronary circulation and myocardial remodeling in patients with aortic stenosis (AS). We aimed to evaluate the relationship between myocardial blood flow and myocardial function in patients with AS, no AS, and aortic valve sclerosis. Methods and Results We included consecutive patients who had resting transthoracic echocardiography and clinically indicated positron emission tomography myocardial perfusion imaging to capture their left ventricular ejection fraction, global longitudinal strain (GLS), and myocardial flow reserve (MFR). The primary outcome was major adverse cardiovascular event (all‐cause mortality, myocardial infarction, or late revascularization). There were 2778 patients (208 with aortic sclerosis, 39 with prosthetic aortic valve, 2406 with no AS, and 54, 49, and 22 with mild, moderate, and severe AS, respectively). Increasing AS severity was associated with impaired MFR ( P <0.001) and GLS ( P <0.001), even when perfusion was normal. Statistically significant associations were noted between MFR and GLS, MFR and left ventricular ejection fraction, and MFR and left ventricular ejection fraction reserve. After a median follow‐up of 349 (interquartile range, 116–662) days, 4 (7.4%), 5 (10.2%), and 6 (27.3%) patients experienced a major adverse cardiovascular event in the mild, moderate, and severe AS groups, respectively. In a matched‐control analysis, patients with mild‐to‐moderate AS had higher rates of impaired MFR (52.9% versus 39.9%; P =0.048) and major adverse cardiovascular event (11.8% versus 3.0%; P =0.002). Conclusions Despite lack of ischemia, as severity of AS increased, MFR decreased and GLS worsened, reflecting worse coronary microvascular health and myocardial remodeling. Positron emission tomography–derived MFR showed a significant independent correlation with left ventricular ejection fraction and GLS. Patients with prosthetic aortic valve showed a high prevalence of impaired MFR.

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confidence: 99%

Myocardial Blood Flow Reserve, Microvascular Coronary Health, and Myocardial Remodeling in Patients With Aortic Stenosis

Alahdab,

Ahmed,

Nayfeh

et al. 2024

JAHA

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Longitudinal analysis of atherosclerotic plaques evolution: an 18F-NaF PET/CT study

Fiz

Piccardo

Morbelli

et al. 2022

Journal of Nuclear Cardiology

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Cardiac microcalcification burden: Global assessment in high cardiovascular risk subjects with Na[18F]F PET-CT

Borges-Rosa

Oliveira-Santos

Silva

et al. 2022

Journal of Nuclear Cardiology

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Aortic valve microcalcification and cardiovascular risk: an exploratory study using sodium fluoride in high cardiovascular risk patients

Cited by 3 publications

References 26 publications

Myocardial Blood Flow Reserve, Microvascular Coronary Health, and Myocardial Remodeling in Patients With Aortic Stenosis

Myocardial Blood Flow Reserve, Microvascular Coronary Health, and Myocardial Remodeling in Patients With Aortic Stenosis

Longitudinal analysis of atherosclerotic plaques evolution: an 18F-NaF PET/CT study

Cardiac microcalcification burden: Global assessment in high cardiovascular risk subjects with Na[18F]F PET-CT

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