Aortic valve calcification: basic science to clinical practice

Akat, Kemal M.; Borggrefe, Martin; Kaden, Jens J.

doi:10.1136/hrt.2007.134783

Cited by 86 publications

(85 citation statements)

References 110 publications

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“…Calcific aortic stenosis (AS) is a progressive disease that has, until recently, been considered a degenerative and unmodifiable process induced by long-lasting mechanical stress on the valve structures [1][2][3]. However, histopathological studies have now demonstrated that the pathogenesis of calcific AS is an active process, sharing a number of similarities with atherosclerosis [1,4].…”

Section: Introductionmentioning

confidence: 99%

“…Inflammation, lipid infiltration, dystrophic calcification, ossification, platelet activation and endothelial dysfunction have been observed in both diseases. Early in the development of AS, active microscopic areas of calcification are seen colocalizing in areas of lipoprotein accumulation and infiltration of inflammatory cells [1,[3][4][5]. As the disease progresses, there is active bone formation involving cells with chondrocytic and ⁄ or osteoblastic characteristics capable of phenotypic differentiation and spontaneous calcification [3,6].…”

Section: Introductionmentioning

confidence: 99%

“…However, histopathological studies have now demonstrated that the pathogenesis of calcific AS is an active process, sharing a number of similarities with atherosclerosis [1,4]. Inflammation, lipid infiltration, dystrophic calcification, ossification, platelet activation and endothelial dysfunction have been observed in both diseases.…”

Section: Introductionmentioning

confidence: 99%

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Undercarboxylated matrix Gla protein is associated with indices of heart failure and mortality in symptomatic aortic stenosis

Ueland¹,

Gullestad²,

Dahl³

et al. 2010

Journal of Internal Medicine

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Abstract. Ueland T, Gullestad L, Dahl CP, Aukrust P, Aakhus S, Solberg OG, Vermeer C, Schurgers LJ (Research Institute for Internal Medicine, University of Oslo, Oslo; University of Oslo, Oslo, Norway; and VitaK & Cardiovascular Research Institute CARIM (CV, LS), Maastricht University, Maastricht, The Netherlands) Undercarboxylated matrix Gla protein is associated with indices of heart failure and mortality in symptomatic aortic stenosis. J Intern Med 2010; 268: 483-492.Objective. Matrix Gla protein (MGP) is a calcification inhibitor and alterations in circulating MGP have been observed in different populations characterized by vascular calcification. We hypothesized that patients with calcific valvular aortic stenosis (AS) would have dysregulated circulating MGP levels.Design and subjects. We examined plasma levels of nonphosphorylated carboxylated and undercarboxylated MGP (dp-cMGP and dp-ucMGP, respectively) in 147 patients with symptomatic severe AS and in matched healthy controls. Main outcome measures.We further investigated the relationship between MGP levels and aortic pressure gradients and valve area by echocardiography and measures of heart failure. Finally, we assessed the prognostic value of elevated plasma dp-ucMGP level in relation to all-cause mortality in patients with AS.Results. We found markedly enhanced plasma levels of dp-cMGP and in particular of dp-ucMGP in patients with symptomatic AS. Although only weak correlations were found with the degree of AS, circulating dp-ucMGP was associated with cardiac function and long-term mortality in multivariate analysis. Conclusions.A dysregulated MGP system may have a role in the development of left ventricular dysfunction in patients with symptomatic AS.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Undercarboxylated matrix Gla protein is associated with indices of heart failure and mortality in symptomatic aortic stenosis

Ueland¹,

Gullestad²,

Dahl³

et al. 2010

Journal of Internal Medicine

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“…However, the majority of these patients had severe AVS. Recently, Akat et al (2009) reported that foci of micro-calcification have been observed in the early stage of CAVD (AVSc or mild AVS). In the Cardiovascular Health Study, elevated phosphate levels, but not calcium, parathyroid hormone, or 25-OHD levels in serum, were associated with AVSc in a community-based cohort of older adults (Linefsky et al, 2011).…”

Section: Relation Between Mineral Metabolism Disturbance and Cavdmentioning

confidence: 99%

Mineral metabolism disturbances are associated with the presence and severity of calcific aortic valve disease

Yang

Zhao

Fang

et al. 2015

J. Zhejiang Univ. Sci. B

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Abstract:Objective: We investigated whether disturbance of calcium and phosphate metabolism is associated with the presence and severity of calcific aortic valve disease (CAVD) in patients with normal or mildly impaired renal function. Methods: We measured serum levels of calcium, phosphate, alkaline phosphatase (AKP), intact parathyroid hormone (iPTH), 25-hydroxyvitamin D (25-OHD), and biomarkers of bone turnover in 260 consecutive patients with normal or mildly impaired renal function and aortic valve sclerosis (AVSc) (n=164) or stenosis (AVS) (n=96) and in 164 age-and gender-matched controls. Logistic regression models were used to determine the association of mineral metabolism parameters with the presence and severity of CAVD. Results: Stepwise increases were observed in serum levels of calcium, phosphate, AKP, and iPTH from the control group to patients with AVS, and with reverse changes for 25-OHD levels (all P<0.001). Similarly, osteocalcin, procollagen I N-terminal peptide, and β-isomerized type I collagen C-telopeptide breakdown products were significantly increased stepwise from the control group to patients with AVS (all P<0.001). In patients with AVS, serum levels of iPTH were positively, in contrast 25-OHD levels were negatively, related to trans-aortic peak flow velocity and mean pressure gradient. After adjusting for relevant confounding variables, increased serum levels of calcium, phosphate, AKP, and iPTH and reduced serum levels of 25-OHD were independently associated with the presence and severity of CAVD. Conclusions: This study suggests an association between mineral metabolism disturbance and the presence and severity of CAVD in patients with normal or mildly impaired renal function. Abnormal bone turnover may be a potential mechanism.

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“…DOI: 10.21883/PJTF.2017.09. 44580.16533 Природа минеральных (кальцинированных) образований на сосуди-стых стенках, будучи причиной трети сердечно-сосудистых болезней [1], продолжает привлекать неослабевающее внимание исследователей. Среди используемых при этом методов важное место принадлежит ИК-спектроскопии [2,3].…”

Section: поступило в редакцию 24 октября 2016 гunclassified

Анализ Ик-Спектров Минерализованных Осадков На Сердечных Клапанах Человека

Иванов-Омский¹,

Ястребов²,

Гуляев³

2017

Письма В Журнал Технической Физики

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Поступило в Редакцию 24 октября 2016 г.С помощью метода ИК-спектроскопии в области колебаний гидроксильных групп выполнен анализ энергии связи минерализованных осадков к клапанам сердца пациентов различного пола и возраста. Выявлена тенденция к нарас-танию энергии связи минерализованных образований с тканью клапанов с увеличением возраста пациентов, которая не зависит от их пола. Проведенный анализ позволяет выработать рекомендации по ранней диагностике кальцинозов, мониторингу их развития и терапии кальцинозов.

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Aortic valve calcification: basic science to clinical practice

Cited by 86 publications

References 110 publications

Undercarboxylated matrix Gla protein is associated with indices of heart failure and mortality in symptomatic aortic stenosis

Undercarboxylated matrix Gla protein is associated with indices of heart failure and mortality in symptomatic aortic stenosis

Mineral metabolism disturbances are associated with the presence and severity of calcific aortic valve disease

Анализ Ик-Спектров Минерализованных Осадков На Сердечных Клапанах Человека

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