Aortic Valve Area (AVA) and Dimensionless Performance Index (DPI) Predicts Progression of Aortic Stenosis

Pressure distribution over the leaflets and effect of bending stiffness on fluid–structure interaction of the aortic valve

“…The peak flow rate, stroke volume and cardiac out in the cases of h = 0.2, 0.3 and 0.5 mm are all within the physiological range for normal adult aortic valves (Leyh et al 1999;Hall 2015), while in the cases of 0.6 and 0.8 mm these variables are below the normal range due to reduced valve opening. The effective orifice area (EOA) represents a measurement of the valve's characteristic resistance and is often used clinically for the quantification of valve stenosis severity (Yoganathan et al 2004;Peck et al 2016). The EOA in our calculation follows the previous definition (Yoganathan et al 2004), EOA (cm 2 ) = Q rms / (51.6 √ p), where Q rms is the root mean square systolic flow rate in ml s −1 and p is the mean systolic pressure drop in mmHg.…”