Aortic valve and aortic root calcifications for predicting major adverse cardiovascular events: NADESICO study

Wada, Shinichi; Iwanaga, Yoshitaka; Nakai, Michikazu; Miyamoto, Yoshihiro; Noguchi, Teruo

doi:10.1007/s00380-022-02187-9

Cited by 6 publications

(4 citation statements)

References 34 publications

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“…The detailed study protocol was described elsewhere 9,10 . Briefly, patients included in the present study were consecutively recruited between December 2008 and April 2013 from the cardiology departments of 15 hospitals in Japan participating in the NADESICO study.…”

Section: Methodsmentioning

confidence: 99%

“…The detailed study protocol was described elsewhere. 9 , 10 Briefly, patients included in the present study were consecutively recruited between December 2008 and April 2013 from the cardiology departments of 15 hospitals in Japan participating in the NADESICO study. Follow‐up after enrollment was conducted every year starting from enrollment until March 2020.…”

Section: Methodsmentioning

confidence: 99%

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Combination of coronary CT angiography, FFR_CT, and risk factors in the prediction of major adverse cardiovascular events in patients suspected CAD

Wada

Iwanaga

Nakai

et al. 2023

Clinical Cardiology

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Background To examine the utility of fractional flow reserve by coronary computed tomography (CT) angiography (FFRCT) for predicting major adverse cardiovascular events (MACE) in patients with suspected coronary artery disease (CAD). Methods This was a nationwide multicenter prospective cohort study including consecutive 1187 patients aged 50−74 years with suspected CAD and had available coronary CT angiography (CCTA). In patients with ≥50% coronary artery stenosis (CAS), FFRCT was further analyzed. The Cox proportional hazards model was used to examine the association of FFRCT and cardiovascular risk factors with incident MACE within 2 years. Results Among 933 patients with available information on MACE within 2 years after enrollment, the incidence rate of MACE was higher in 281 patients with CAS than in those without CAS (6.11 vs. 1.16 per 100 patient‐year). In 241 patients with CAS, the Cox proportional hazards analysis showed that FFRCT as well as diabetes mellitus and low high‐density lipoprotein cholesterol level were independently associated with incident MACE. Moreover, the hazard ratio was significantly higher in patients harboring all three factors compared to those harboring 0−2 of the three factors (6.01; 95% confidence interval: 2.77−13.03). Conclusions Combinatorial assessment using CCTA for stenosis, FFRCT, and risk factors was useful for more accurate prediction of MACE in patients with suspected CAD. Among patients with CAS, those with lower FFRCT, diabetes mellitus, and low high‐density lipoprotein cholesterol level were at highest risk for MACE during the 2‐year period following enrollment.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Combination of coronary CT angiography, FFR_CT, and risk factors in the prediction of major adverse cardiovascular events in patients suspected CAD

Wada

Iwanaga

Nakai

et al. 2023

Clinical Cardiology

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“…Fashanu et al revealed that VC was associated with the incidence of HF and left ventricular function 5 . A cohort study found that aortic valve calcification (AVC) showed predictive value for the incidence of major adverse cardiovascular events 6 . Patients with valvular diseases were associated with the incidence of AF.…”

Section: Introductionmentioning

confidence: 99%

“… 5 A cohort study found that aortic valve calcification (AVC) showed predictive value for the incidence of major adverse cardiovascular events. 6 Patients with valvular diseases were associated with the incidence of AF. In addition, VC was also an independent predictor of the incidence of AF.…”

Section: Introductionmentioning

confidence: 99%

Predictive value of valvular calcification for the recurrence of persistent atrial fibrillation after radiofrequency catheter ablation

Liu,

Li,

Long

et al. 2023

Clinical Cardiology

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BackgroundValvular calcification (VC) is an independent risk factor for cardiovascular diseases. The relationship between VC and atrial fibrillation is not clear.HypothesisWe treated the aortic valve, mitral valve, and tricuspid valve as a whole and considered the possible association between VC and recurrence of persistent atrial fibrillation (PsAF) after radiofrequency catheter ablation (RFCA).MethodsThis study involved 2687 PsAF patients who underwent RFCA. Data were collected to explore the relationship between VC and outcome. VC was defined by echocardiography in aortic valve, mitral valve, or tricuspid valve. After 1 year follow‐up, subgroup analysis, mixed model regression analysis, and score system analysis were performed. The external validation of 133 patients demonstrated the accuracy of this clinical prediction model.ResultsOverall, 2687 inpatients were assigned to the recurrence group (n = 682) or the no recurrence group (n = 2005) with or without VC. Compared to patients with no recurrence, the incidence of VC was higher in recurrence patients. Recurrence was present in 18.5%, 34.9%, 39.3%, and 52.0% of the four groups, which met VC numbers of 0, 1, 2, and 3, respectively. After adjustment for potential confounding factors, VC was an independent risk factor for AF recurrence in several models. For multivariable logistic regression, a scoring system was established based on the regression coefficient. The receiver operating characteristic area of the scoring system was 0.787 in the external validation cohort.ConclusionsVC was an independent risk factor for AF recurrence in PsAF after RFCA. The scoring system may be a useful clinical tool to assess AF recurrence.

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Clinical impact of cardiovascular calcifications on stroke incidence in primary prevention: analysis in NADESICO study

Wada,

Iwanaga,

Nakai

et al. 2024

Heart Vessels

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Aortic valve and aortic root calcifications for predicting major adverse cardiovascular events: NADESICO study

Cited by 6 publications

References 34 publications

Combination of coronary CT angiography, FFR_CT, and risk factors in the prediction of major adverse cardiovascular events in patients suspected CAD

Combination of coronary CT angiography, FFR_CT, and risk factors in the prediction of major adverse cardiovascular events in patients suspected CAD

Predictive value of valvular calcification for the recurrence of persistent atrial fibrillation after radiofrequency catheter ablation

Clinical impact of cardiovascular calcifications on stroke incidence in primary prevention: analysis in NADESICO study

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Aortic valve and aortic root calcifications for predicting major adverse cardiovascular events: NADESICO study

Cited by 6 publications

References 34 publications

Combination of coronary CT angiography, FFRCT, and risk factors in the prediction of major adverse cardiovascular events in patients suspected CAD

Combination of coronary CT angiography, FFRCT, and risk factors in the prediction of major adverse cardiovascular events in patients suspected CAD

Predictive value of valvular calcification for the recurrence of persistent atrial fibrillation after radiofrequency catheter ablation

Clinical impact of cardiovascular calcifications on stroke incidence in primary prevention: analysis in NADESICO study

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Combination of coronary CT angiography, FFR_CT, and risk factors in the prediction of major adverse cardiovascular events in patients suspected CAD

Combination of coronary CT angiography, FFR_CT, and risk factors in the prediction of major adverse cardiovascular events in patients suspected CAD