Aortic thrombosis after DVT and PE in a young COVID-19 patient

Baltrūnas, Tomas; Račytė, Austėja; Pikturnaitė, Gabija; Skrebūnas, Arminas; Vaišnytė, Birutė

doi:10.1016/j.avsg.2021.07.005

Cited by 3 publications

(3 citation statements)

References 16 publications

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“…These patients are usually managed with anticoagulation therapy as a standard of care unless vascular intervention such as thromboembolectomy is required for larger occlusive thrombus in order to prevent emboli shower [1,28,29]. Although rare, these aortic thromboses have also been associated with occlusion of distal end arteries affecting organs such as the kidney and spleen [29][30][31] (Fig. 3).…”

Section: Aortic Thrombosismentioning

confidence: 99%

Vascular findings in CTA body and extremity of critically ill COVID-19 patients: commonly encountered vascular complications with review of literature

et al. 2022

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The purpose of our review is to discuss the role of CT angiography (CTA) in evaluating a variety of vascular complications in critically ill COVID-19 patients. The COVID-19 pandemic continues to be a worldwide health threat. While COVID-19 pneumonia is the most common and well-recognized presentation of COVID-19, severely ill hospitalized patients often present with extrapulmonary systemic findings. Vascular complications occur not only due to known viral-induced vasculopathy, coagulopathy, and related “cytokine storm,” but also due to anticoagulation medication used during hospitalization. There is a paucity of articles describing extrapulmonary vascular findings, especially in critically ill COVID-19 patients. In our article, we discuss commonly encountered vascular imaging findings in the body (chest, abdomen, and pelvis) and extremities, the importance of early radiological detection, and the role of CTA in the management of critically ill COVID-19 patients.

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Section: Aortic Thrombosismentioning

confidence: 99%

Vascular findings in CTA body and extremity of critically ill COVID-19 patients: commonly encountered vascular complications with review of literature

et al. 2022

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“…Aortic thrombosis has been described in case reports of patients with COVID-19 and is associated with important complications [ 10 – 12 ]. One study suggests that the occurrence of the synchronous damage involving both the lumen surface (endothelial dysfunction, endotheliitis, and endothelial detachment) and the adventitia (inflammation and occlusive thrombosis of vasa vasorum) could be the key points related to the fatal outcome in patients with SARS-CoV-2 [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…There are also warnings that the adenovirus vector vaccine ChAdOx1 nCoV-19 can result in the rare development of immune thrombotic thrombocy-topenia mediated by platelet-activating antibodies against PF4, which clinically mimics autoimmune heparin-induced thrombocytopenia [8,9]. Aortic thrombosis has been described in case reports of patients with COVID-19 and is associated with important complications [10][11][12]. One study suggests that the occurrence of the synchronous damage involving both the lumen surface (endothelial dysfunction, endotheliitis, and endothelial detachment) and the adventitia (inflammation and occlusive thrombosis of vasa vasorum) could be the key points related to the fatal outcome in patients with SARS-CoV-2 [13].…”

Section: Introductionmentioning

confidence: 99%

Aortic Thrombosis Associated with Three Types of COVID-19 Vaccine

de Godoy,

Neto,

da Silva

et al. 2023

Case Reports in Surgery

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Aortic thrombosis has been studied little in patients with COVID-19 and an association has recently been reported with the vaccine for this disease. The aim of the present study is to report five cases of aortic thrombosis at our institution within a three-month period associated with the COVID-19 vaccine. Five cases of aortic thrombosis were evaluated—three women and two men aged 29, 49, 51, 60, and 79 years. Four thrombi involved the thoracic aortic and one involved the abdominal aorta, with embolisms found in the kidneys, spleen, liver, upper limbs, and lower limbs. Embolectomy was performed on the limbs, and anticoagulant therapy was performed for the abdominal arteries. The patients recovered well and anticoagulant therapy was maintained. Aortic thrombosis is uncommon but was associated with the AstraZeneca vaccine in this case series.

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Amoxicillin/clavulanic-acid/dexamethasone

2022

Reactions Weekly

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Amoxicillin/clavulanic-acid/dexamethasoneVascular graft infection and off-label use: case report A 51-year-old man developed vascular graft infection during off-label treatment with dexamethasone for COVID-19. He also received off-label treatment with amoxicillin and clavulanic acid for COVID-19.The man presented to an emergency department on 15 December 2020 with chest pain and hypertensive crisis corrected by unspecified ACE inhibitors. Upon further evaluation, he was found to be positive for COVID-19. He started receiving off-label treatment with amoxicillin, clavulanic-acid and dexamethasone [routes and dosages not stated]. Additionally, he received unspecified low-molecular-weight-heparins [low-molecular-weight heparin] in prophylactic dosage. However, he reported worsening pain and weakness in the left lower limb on the following days. Further analyses revealed bilateral viral pneumonia with partial resorption along with pulmonary embolism in the right middle lobes of lateral and medial segments. As a result, lowmolecular-weight-heparins dose was increased to therapeutic dosage. Additionally, thrombosis of infrarenal aorta, bilateral common iliac arteries and left external iliac artery was observed. Further, his leg ischemia deteriorated. He then underwent an extraanatomic axillo-bifemoral bypass on 28 December. However, wound healing appeared to be compromised on day 3 of operation. An ultrasound scan on the postoperative day 5 confirmed vascular graft infection [duration of treatment to reaction onset and outcome not stated]. His vascular graft infection was attributed to administration of corticosteroid (dexamethasone), ongoing pneumonia, obesity and prolonged preoperative hospitalization. He recovered from COVID-19. On 8 January, the infected axillobifemoral shunt was removed. Additionally, he underwent an open endarterectomy of infrarenal aorta, right common iliac and left external iliac arteries and remote endarterectomy in the left common iliac artery. The blood flow was restored to his legs successfully. He was discharged from the hospital on 25 January without any complications.

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Aortic thrombosis after DVT and PE in a young COVID-19 patient

Cited by 3 publications

References 16 publications

Vascular findings in CTA body and extremity of critically ill COVID-19 patients: commonly encountered vascular complications with review of literature

Vascular findings in CTA body and extremity of critically ill COVID-19 patients: commonly encountered vascular complications with review of literature

Aortic Thrombosis Associated with Three Types of COVID-19 Vaccine

Amoxicillin/clavulanic-acid/dexamethasone

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