Aortic stiffness, inflammation, denutrition and type 2 diabetes in the elderly

Blacher, Jacques; Protogerou, Athanase D.; Henry, Olivier; Czernichow, Sébastien; Iaria, P.; Zhang, Y.; Agnoletti, Davide; Safar, Michel E.

doi:10.1016/j.diabet.2011.07.006

Cited by 12 publications

(13 citation statements)

References 40 publications

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“…First, and because of our inclusion criteria, there was a high prevalence of CV disease, affecting 74% of our participants, which might potentially limit the extrapolation of our results to other elderly populations. However, similar prevalence of CV diseases were previously reported (Vischer et al, 2009;Blacher et al, 2012). Second, our population was very old: mean age was 84 ± 7 years; range: 65-100 years.…”

Section: Limits Of the Studysupporting

confidence: 55%

“…An increased PP is the principal hemodynamic consequence of increased aortic stiffness with age (Protegerou et al, 2007). In our cohort study, mean pulse pressure was 66 ± 15 mmHg, and was similar than mean value found by Blacher et al, 2012, in the PROTE-GER study (66 ± 18 mmHg). In this study, a cohort of very old frail subjects was investigated prospectively (mean age: 85 ± 7 years) to delineate for the first time the pathophysiological role of arterial stiffness on total and CV mortality.…”

Section: Arterial Pulse Pressurementioning

confidence: 64%

“…Furthermore, our findings supported the hypothesis that orosomucoid was superior to CRP in mortality risk assessment strategies for elderly patients. The PROTEGER study confirmed the harmful role played by inflammation and orosomucoid level on mortality of hospitalized elderly (Blacher et al, 2012).…”

Section: Inflammationmentioning

confidence: 70%

“…Mean PWV was lower in our subjects compared with those of PRO-TEGER study. Although our data could be interpreted with caution, PWV did not differ between survivors and deceased (Blacher et al, 2012). The relations of PUFA to clinical measures such as vascular stiffness are sparse and inconclusive.…”

Section: Pulse Wave Velocitymentioning

confidence: 84%

“…Interestingly, in our diabetic subjects, those who used antidiabetic agents had higher levels of arachidonic acid and DHA (+16% and +14%, respectively) but only in EC. Nevertheless, type 2 diabetes is significant risk factor for mortality in the elderly (Ayaz et al, 2014;Blacher et al, 2012).…”

Section: Dysglycemiamentioning

confidence: 99%

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Metabolic disorders and blood fatty acids status in hospitalized very old patients: part I of the Alpha-linolenage study

Henry

Combe

Vaysse

et al. 2015

OCL

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-Background: previous studies showed that hospitalized elderly women had low Polyunsaturated fatty acids (PUFA) intake and concomitantly showed biochemical indices of essential fatty acid (EFA) insufficiency. Objectives: the Alpha-Linolenage study aimed to improve health parameters of hospitalized very elderly patients, aged 85 years. The objective of the Part I of the Alpha-linolenage study was to assess blood fatty acid status and parameters of metabolic disorders of these patients at the baseline. Design: from 2009 to 2011, 188 patients entering the geriatric department of Emile Roux Hospitals, Île-de-France region, France, were included. Data on the lipid status were obtained through analysis of fatty acid compositions of plasma cholesterol esters and erythrocyte phospholipids. Results: because of our inclusion criteria, there was a high prevalence of CV disease, affecting 74% of our participants. Patients ingested an average of 1586 kcal per day. Fat accounted for 49.2 g/d. Both LA and ALA intakes were not reached, i.e. on average 5 g/d of LA vs. 8-10 g and 1.2 g/d of ALA vs. 2-2.5 g recommended, respectively. The LA and ALA blood status reflected this situation; their contents were lower than those waited under sufficient EFA diet. Conclusion: in very elderly patients a status of chronic disease may generate CV or mortality risk factors. A low fat intake, with both insufficient LA and ALA intakes might favor the harmful role played by de novo lipogenesis, Indeed, a cornerstone of dietary guidelines, i.e. restriction of fat and saturated fat, may be related to risk of disease. The second part of the alpha-linolenage study will aim to improve markers of the metabolic disorders by providing sufficiently lipids.

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Section: Limits Of the Studysupporting

confidence: 55%

Section: Arterial Pulse Pressurementioning

confidence: 64%

Section: Inflammationmentioning

confidence: 70%

Section: Pulse Wave Velocitymentioning

confidence: 84%

Section: Dysglycemiamentioning

confidence: 99%

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Metabolic disorders and blood fatty acids status in hospitalized very old patients: part I of the Alpha-linolenage study

Henry

Combe

Vaysse

et al. 2015

OCL

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Hospital Diet Enriched With Rapeseed or Sunflower Oils Is Associated With a Decrease in Plasma 16:1n‐7 and Some Metabolic Disorders in the Elderly

Combe

Henry

López

et al. 2018

Lipids

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We recently demonstrated that the prevalence of dysglycemia was high among hospitalized elderly people who were fed a low fat diet (27.7% of energy) and was positively associated with plasma 16:1n-7, an indicator of de novo lipogenesis (DNL). Fatty acids in the DNL pathway have been shown to be associated with a higher risk of metabolic syndrome (MetS). The purpose of this study was to investigate the potential beneficial effects of fat enrichment (up to 34.1%en) of the hospital diet in 111 patients (30 men and 81 women, 84 ± 7 years) during 6 weeks. Based on gender, they were randomly given a diet supplemented either with rapeseed oil (RO) or with sunflower oil (SO). Fatty acids of cholesteryl esters and erythrocyte phospholipids and markers of metabolic disorders were evaluated before and after dietary intervention. Both enriched diets significantly, and to a similar extent, decreased (1) the overall prevalence of dysglycemia (by 25-33%) and MetS (by 31-43%) and (2) plasma 16:1n-7 mol% in men and women. Dysglycemia prevalence adjusted by the diets was reduced in men versus baseline; no change was found in women. Enrichment of the diet with RO or SO resulted in a difference in fatty acid compositions, that is, EPA (mol%) and the omega-3 index increased with RO, while proportions of 18:1n-7, 18:1n-9, and EPA decreased with SO. These findings highlight the need for adequate fat intake in the elderly. For supplementation of the hospital diet, RO, which led to a higher proportion of circulating n-3 polyunsaturated fatty acids (PUFA) and is known to be beneficial, may be preferred to SO.

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Association between whole blood viscosity and arterial stiffness in patients with type 2 diabetes mellitus

Tian

Liu

et al. 2014

Endocrine

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Type 2 diabetes mellitus (DM) carries an increased risk for cardiovascular complications. The brachial-ankle pulse wave velocity (baPWV) is an index for early atherosclerotic changes. Recently, the effect of altered blood rheology on atherosclerosis has received attention. Therefore, this study aimed to examine the association of hemorheological parameters with baPWV in patients with DM. In this cross-sectional study, we investigated the relationship between rheological parameters and baPWV in 323 control subjects (160 men and 163 women) and 382 patients with DM (170 men and 212 women). The participants with DM had higher whole blood viscosity (WBV) levels both at low shear rate (3 s(-1)) and at high shear rate (200 s(-1)) than those without DM. Different metabolic parameters were compared across WBV (3 s(-1)) quartiles. The mean values of baPWV gradually increased with WBV (3 s(-1)) quartiles. In addition, there was a positive correlation between baPWV and WBV 3 s(-1) in patients with DM after adjusting confounding factors (r = 0.285, p = 0.039). Stepwise multiple linear regression analysis further revealed that WBV (3 s(-1)) is a significant determinant for increased baPWV in DM (β = 0.184; p < 0.001). However, there were no association between WBV (3 s(-1)) and baPWV in control subjects. The findings showed that baPWV increased as WBV (3 s(-1)) elevated in DM. Moreover, WBV (3 s(-1)) is independently associated with baPWV even after adjusting other cardiovascular risk factors. Early detection of abnormal WBV levels at low shear rate should warrant for early search of undetected arterial stiffness in patients with DM.

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Aortic stiffness, inflammation, denutrition and type 2 diabetes in the elderly

Cited by 12 publications

References 40 publications

Metabolic disorders and blood fatty acids status in hospitalized very old patients: part I of the Alpha-linolenage study

Metabolic disorders and blood fatty acids status in hospitalized very old patients: part I of the Alpha-linolenage study

Hospital Diet Enriched With Rapeseed or Sunflower Oils Is Associated With a Decrease in Plasma 16:1n‐7 and Some Metabolic Disorders in the Elderly

Association between whole blood viscosity and arterial stiffness in patients with type 2 diabetes mellitus

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