Aortic stiffness increases during prolonged sitting independent of intermittent standing or prior exercise

Wright, Alexander; Stavres, Jon; Galloway, Riley; Donahue, Paul T.; Sha, Zhanxin; McCoy, Stephanie M.

doi:10.1007/s00421-022-05079-y

Cited by 4 publications

(2 citation statements)

References 106 publications

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“…The potential short duration of benefits from periodic standing breaks may also explain the lack of mitigation from sitting-induced changes in AIx@75, DBP, and cfPWV. Our cfPWV results align with previous work showing periodic standing interruptions to be ineffective at reducing sitting-induced increases in cfPWV (39,58). These findings further strengthen the evidence suggesting that periodic standing interruptions may be insufficient to provide cardiovascular benefits against prolonged sitting.…”

Section: Discussionsupporting

confidence: 91%

“…cfPWV increased after the sitting (P < 0.01; Cohen's d = 0.55) and standing conditions (P < 0.01; Cohen's d = 0.63), but not the elliptical condition (P = 0.43, Cohen's d = 0.13) (Fig. 2A), similar to previously reported effects (12,14,17,(37)(38)(39). In addition, ΔcfPWV was smaller in the elliptical condition compared with the sitting (0.1 ± 0.4 m•s −1 vs 0.5 ± 0.4; P < 0.01; Cohen's d = 0.92) and standing conditions (0.1 ± 0.4 vs 0.4 ± 0.3 m•s −1 ;…”

Section: Pulse Wave Velocitysupporting

confidence: 90%

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Seated Elliptical Exercise, But Not Periodic Standing, Alleviates Sitting-Induced Changes to Arterial Wave Reflections

ATHAIDE,

ROBERTSON,

DEVRIES

et al. 2023

Medicine &Amp; Science in Sports &Amp; Exercise

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Purpose Sedentary behaviour may contribute to increased central wave reflection due to associated peripheral vasoconstriction, yet its impact on central hemodynamics and the mitigating effects of interventional strategies have not been thoroughly investigated. We tested whether standing, or seated elliptical breaks alleviate the deleterious effects of prolonged sitting on central wave reflections. Methods Eighteen healthy adults (9 females, 25 ± 3 years) completed three 3-hour protocols on separate days: uninterrupted sitting, sitting with periodic standing, and sitting with periodic seated elliptical activity. Central wave reflection, central pulse wave velocity and lower-limb pulse wave velocity were measured before and after each intervention. Results Central relative wave reflection magnitude (RM) increased during sitting (0.31 ± 0.05 to 0.35 ± 0.05; p < 0.01) but did not change following standing (0.30 ± 0.05 to 0.32 ± 0.04; p = 0.19) or elliptical protocols (0.30 ± 0.05 to 0.30 ± 0.04; p > 0.99). The change in RM during prolonged sitting (ΔRM) was attenuated with elliptical activity (0.04 ± 0.05 vs. 0.00 ± 0.03; p = 0.02) but not with periodic standing (0.04 ± 0.04 vs. 0.02 ± 0.05; p = 0.54). In addition, augmentation index and central pulse wave velocity increased following sitting (both p < 0.01) and periodic standing (both p < 0.01) but were unchanged following elliptical activity. Lower limb pulse wave velocity did not change following sitting (p = 0.73) or standing (p = 0.21) but did decrease following elliptical activity (p = 0.03). Conclusions Prolonged sitting without interruptions increased central wave reflection while elliptical but not standing interruptions were able to ameliorate multiple sitting-induced vascular consequences. More work is required to examine the long-term effectiveness of interruption strategies, as well as the optimal type, frequency, and duration for reducing vascular risk associated with sedentary behaviours.

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Section: Discussionsupporting

confidence: 91%

Section: Pulse Wave Velocitysupporting

confidence: 90%

Seated Elliptical Exercise, But Not Periodic Standing, Alleviates Sitting-Induced Changes to Arterial Wave Reflections

ATHAIDE,

ROBERTSON,

DEVRIES

et al. 2023

Medicine &Amp; Science in Sports &Amp; Exercise

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Uninterrupted prolonged sitting and arterial stiffness: moderating effect of prior aerobic exercise in physically active adults

Riley,

Paterson,

Bates-Fraser

et al. 2024

Eur J Appl Physiol

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The effect of cardiorespiratory fitness and habitual physical activity on cardiovascular responses to 2 h of uninterrupted sitting

Paterson,

Stone,

Turner

et al. 2024

Journal of Applied Physiology

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Prolonged uninterrupted sitting of >3-hours has been shown to acutely cause central and peripheral cardiovascular dysfunction. However, individuals rarely sit uninterrupted for >2-hours, and the cardiovascular response to this time is currently unknown. In addition, whilst increased cardiorespiratory fitness (CRF) and habitual physical activity (HPA) are independently associated with improvements in central and peripheral cardiovascular function, it remains unclear whether they influence the response to uninterrupted sitting. This study sought to 1) determine whether 2-hours of uninterrupted sitting acutely impairs carotid-femoral pulse wave velocity (cfPWV), femoral ankle PWV (faPWV), and central and peripheral blood pressure, and (2) to investigate the associations between CRF and HPA versus PWV changes during uninterrupted sitting. Following 2-hours of uninterrupted sitting, faPWV significantly increased (mean difference [MD] = 0.26 m·s-1, standard error [SE] = 0.10, p = 0.013) as did diastolic blood pressure (MD = 2.83 mmHg, SE = 1.08, p = 0.014), however cfPWV did not significantly change. Whilst our study shows 2-hours uninterrupted sitting significantly impairs faPWV, neither CRF ( r = 0.105, p = 0.595) nor HPA ( r = -0.228, p = 0.253) were associated with the increases.

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Aortic stiffness increases during prolonged sitting independent of intermittent standing or prior exercise

Cited by 4 publications

References 106 publications

Seated Elliptical Exercise, But Not Periodic Standing, Alleviates Sitting-Induced Changes to Arterial Wave Reflections

Seated Elliptical Exercise, But Not Periodic Standing, Alleviates Sitting-Induced Changes to Arterial Wave Reflections

Uninterrupted prolonged sitting and arterial stiffness: moderating effect of prior aerobic exercise in physically active adults

The effect of cardiorespiratory fitness and habitual physical activity on cardiovascular responses to 2 h of uninterrupted sitting

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