Aortic stenosis and statins

Reply to the Editor

“…We appreciate the comments by Vedamurthy and associates 1 on our meta-analysis. 2 The standardized mean difference (SMD) is used as a summary statistic in meta-analyses when the studies all assess the same outcome but measure it in a variety of ways (eg, all studies measure depression, but they use different psychometric scales).…”

“…In a meta-analysis of negative pressure wound therapy, 4 for instance, a change in wound area per day (in square centimeters), a change in wound area until surgical closure (in square centimeters), and a relative change in wound area until surgical closure or hospital discharge (in percentages) were combined by using the SMD method. Although Vedamurthy and associates 1 projected the AVA and PAJV change per year by using the baseline values and percentage change data expressed in the original articles, precise calculation methods were not mentioned. Was the mean of the absolute change in the AVA or PAJV calculated by multiplying the mean of the baseline value by the mean of the percentage change?…”