Aortic Length: Angiocardiographic Measurements

Dotter, Charles T.; Roberts, Douglas J.; Steinberg, Israel

doi:10.1161/01.cir.2.6.915

Cited by 38 publications

(21 citation statements)

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“…It should be noted that this association persisted after BSA adjustment. Our values agree with thoracic aorta lengthening predicted from Dotter et al 8 model, that used 2D angiocardiographic images. Accordingly, and for an age range of 30-70 y.o., these authors predict values of %1.4 cm/10 years (4%/10 years).…”

Section: Relationships Of Aging With Aortic Morphometrysupporting

confidence: 90%

Aging Impact on Thoracic Aorta 3D Morphometry in Intermediate-Risk Subjects: Looking Beyond Coronary Arteries with Non-Contrast Cardiac CT

et al. 2011

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An increasing number of intermediate risk asymptomatic subjects benefit from measures of atherosclerosis burden like coronary artery calcification studies with non-contrast heart computed tomography (CT). However, additional information can be derived from these studies, looking beyond the coronary arteries and without exposing the patients to further radiation. We report a semi-automatic method that objectively assesses ascending, arch and descending aorta dimension and shape from non-contrast CT datasets to investigate the effect of aging on thoracic aorta geometry. First, the segmentation process identifies the vessel centerline coordinates following a toroidal path for the curvilinear portion and axial planes for descending aorta. Then, reconstructing oblique planes orthogonal to the centerline direction, it iteratively fits circles inside the vessel cross-section. Finally, regional thoracic aorta dimensions (diameter, volume and length) and shape (vessel curvature and tortuosity) are calculated. A population of 200 normotensive men was recruited. Length, mean diameter and volume differed by 1.2 cm, 0.13 cm and 21 cm(3) per decade of life, respectively. Aortic shape uncoiled with aging, reducing its tortuosity and increasing its radius of curvature. The arch was the most affected segment. In conclusion, non-contrast cardiac CT imaging can be successfully employed to assess thoracic aorta 3D morphometry.

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Section: Relationships Of Aging With Aortic Morphometrysupporting

confidence: 90%

Aging Impact on Thoracic Aorta 3D Morphometry in Intermediate-Risk Subjects: Looking Beyond Coronary Arteries with Non-Contrast Cardiac CT

et al. 2011

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“…These crosssectional morphologies of central elastic arteries have been studied relatively extensively in relation to the arterial remodeling with aging. However, little information is available regarding the longitudinal morphological changes in the aorta (i.e., the aortic length) (9). It is generally thought that the aorta and large elastic arteries become longer and tortuous with aging (10 -12).…”

mentioning

confidence: 99%

Age-Associated Elongation of the Ascending Aorta in Adults

Sugawara

Hayashi

Yokoi

et al. 2008

JACC: Cardiovascular Imaging

278

211

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“…1(a)) supports tremendous hemodynamic loading, expanding ($11% area change [1]) during systole and elastically recoiling during diastole to augment the forward flow of blood and coronary perfusion [2]. Although it is only about 5 cm long [3,4] (15% of the total length of the thoracic aorta), the ascending aorta is involved in 60% of all thoracic aortic aneurysms [5]. Aneurysm dissection and rupture (resulting in imminent death) are the primary risks associated with ascending thoracic aortic aneurysm (ATAA), occurring when the remodeled tissue is no longer able to withstand the stresses generated by the arterial pressure.…”

Section: Introductionmentioning

confidence: 93%

Failure of the Porcine Ascending Aorta: Multidirectional Experiments and a Unifying Microstructural Model

Witzenburg

Dhume

Shah

et al. 2017

Journal of Biomechanical Engineering

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The ascending thoracic aorta is poorly understood mechanically, especially its risk of dissection. To make better predictions of dissection risk, more information about the multidimensional failure behavior of the tissue is needed, and this information must be incorporated into an appropriate theoretical/computational model. Toward the creation of such a model, uniaxial, equibiaxial, peel, and shear lap tests were performed on healthy porcine ascending aorta samples. Uniaxial and equibiaxial tests showed anisotropy with greater stiffness and strength in the circumferential direction. Shear lap tests showed catastrophic failure at shear stresses (150-200 kPa) much lower than uniaxial tests (750-2500 kPa), consistent with the low peel tension ($60 mN/mm). A novel multiscale computational model, including both prefailure and failure mechanics of the aorta, was developed. The microstructural part of the model included contributions from a collagenreinforced elastin sheet and interlamellar connections representing fibrillin and smooth muscle. Components were represented as nonlinear fibers that failed at a critical stretch. Multiscale simulations of the different experiments were performed, and the model, appropriately specified, agreed well with all experimental data, representing a uniquely complete structure-based description of aorta mechanics. In addition, our experiments and model demonstrate the very low strength of the aorta in radial shear, suggesting an important possible mechanism for aortic dissection.

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Aortic Length: Angiocardiographic Measurements

Cited by 38 publications

References 1 publication

Aging Impact on Thoracic Aorta 3D Morphometry in Intermediate-Risk Subjects: Looking Beyond Coronary Arteries with Non-Contrast Cardiac CT

Aging Impact on Thoracic Aorta 3D Morphometry in Intermediate-Risk Subjects: Looking Beyond Coronary Arteries with Non-Contrast Cardiac CT

Age-Associated Elongation of the Ascending Aorta in Adults

Failure of the Porcine Ascending Aorta: Multidirectional Experiments and a Unifying Microstructural Model

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