2010
DOI: 10.1016/j.autrev.2010.02.014
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Aortic involvement in giant cell arteritis

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Cited by 48 publications
(28 citation statements)
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“…IRF is associated with HLA-DRB1*03 [23] which also represents a major genetic risk factor for HT, together with HLA-DR4 and -DR5 [15]. In addition, both HT [16,24] and IRF [2][3][4][5]25] cluster with other autoimmune diseases. Histologically, besides the abundance of fibrotic tissue, IRF is characterized by a lympho-plasmocytic infiltrate often organized in nodular structures with germinal centers [1].…”
Section: Discussionmentioning
confidence: 95%
“…IRF is associated with HLA-DRB1*03 [23] which also represents a major genetic risk factor for HT, together with HLA-DR4 and -DR5 [15]. In addition, both HT [16,24] and IRF [2][3][4][5]25] cluster with other autoimmune diseases. Histologically, besides the abundance of fibrotic tissue, IRF is characterized by a lympho-plasmocytic infiltrate often organized in nodular structures with germinal centers [1].…”
Section: Discussionmentioning
confidence: 95%
“…GCA (Horton's disease) is the most common systemic vasculitis that involves the aorta [47,49,[56][57][58][59][60][61]. GCA primarily, if not exclusively, affects persons older than 50 years of age.…”
Section: Giant Cell Arteritismentioning
confidence: 99%
“…However, FDG-PET has revealed that the majority of patients have aortitis in the early phase of the disease [12]. A recent large-scale study of a series of 35 GCA patients showed that FDG-PET indicated vascular uptake in 83% of GCA patients at diagnosis [13].…”
Section: Discussionmentioning
confidence: 98%