Aortic Dissection: A Review of the Pathophysiology, Management and Prospective Advances

Sayed, A.; Munir, Malak; Bahbah, Eshak I.

doi:10.2174/1573403x16666201014142930

Cited by 52 publications

(54 citation statements)

References 137 publications

(181 reference statements)

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“…Aortic coarctation is a state in which blood in the aortic lumen enters the aortic mesentery from a tear in the aortic intima, causing the mesentery to split and expand in the direction of the long axis of the aorta forming a true/false separation of the two lumens of the aortic wall [ 10 ]. The peak age of onset of aortic coarctation is 50–70 years, with a male to female ratio of about 2–3:1.…”

Section: Discussionmentioning

confidence: 99%

The Correlation and Copathogenesis of Coronary Aortic Sandwich and Renal Cysts

Zhang

Gong

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To determine the correlation for aortic occlusion and hydronephrosis and the pathogenesis of copathogenesis. Methods. A retrospective census was established to probe the correlation with renal cysts by gathering aortic coarctation details concerning generic symptoms, diabetes, and liver and kidney profiles from 244 hospitalized aortic clinographers from April 2014 to December 2021 (study category, SG category), 150 hypertensive clients with primary hypertension attending our institution in the same period (matched category, MG category), and 150 able-bodied volunteers (control category, CG category). Results. (1) Intercategory discrepancies in regard to aortic occlusion, diabetic malfunction, and kidney and liver abnormality were neither mutually nor predominantly measured ( P > 0.05 ); (2) 244 enrolled SG for aortic occlusion and 150 CG for aortic occlusion were categorized by whether or not aortic occlusion was manifested, and the correlation between maternal age, gender, diabetic malfunction, and kidney and liver abnormality and renal cysts was estimated. The correlation of clogged aorta was demonstrated by a multifactorial logistic regression with gender and the presence of renal cysts ( P < 0.05 ); (3) the correlation of clogged aorta was demonstrated by a multifactorial logistic regression with renal cysts as an independent risk factor for clogged aorta (95% CI: 1.028–10.291; P = 0.031 ). Conclusion. As renal cysts are an autonomous risk of aortic coarctation, it is recommendable to strengthen clinical investigations such as monitoring of clinical blood pressures in kidney cyst recipients to assess their aortic function in order to evaluate their prognosis and minimize the prevalence of aortic coarctation.

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Section: Discussionmentioning

confidence: 99%

The Correlation and Copathogenesis of Coronary Aortic Sandwich and Renal Cysts

Zhang

Gong

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Aortic dissection (AD) is a life-threatening cardiovascular disease with a high mortality rate. 1,2 Aortic dissection can be classified into Stanford type A or type B based on the involvement of ascending aorta or not. 3 Notably, AD patients present a higher incidence of men than females (around 1.7:1 male to female ratio).…”

Section: Introductionmentioning

confidence: 99%

“…Aortic dissection (AD) is a life‐threatening cardiovascular disease with a high mortality rate 1,2 . Aortic dissection can be classified into Stanford type A or type B based on the involvement of ascending aorta or not 3 .…”

Section: Introductionmentioning

confidence: 99%

Th1, Th2, and Th17 cells are dysregulated, but only Th17 cells relate to C‐reactive protein, D‐dimer, and mortality risk in Stanford type A aortic dissection patients

Song

Deng

Shen

et al. 2022

Clinical Laboratory Analysis

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Background: T helper (Th) cells are closely involved in vascular inflammation, endothelial dysfunction, and atherogenesis, which are the hallmarks of aortic dissection (AD). This study aimed to evaluate the clinical value of Th1, Th2, and Th17 cell measurements in Stanford type A AD patients. Methods: Stanford type A AD patients (N=80) and non-AD patients with chest pain (N = 40) were recruited. Then, Th1, Th2, and Th17 cells in peripheral blood CD4 + T cells from all participants were detected by flow cytometry. The 30-day mortality of Stanford type A AD patients was recorded.Results: Th1 and Th17 cells were higher, while Th2 cells were lower in Stanford type A AD patients compared with non-AD patients (all p < 0.001). Meanwhile, Th1 cells (area under curve (AUC): 0.734, 95% confidence interval (CI): 0.640-0.828), Th2 cells (AUC: 0.841, 95% CI: 0.756-0.925), and Th17 cells (AUC: 0.898, 95% CI: 0.839-0.957) could distinguish Stanford type A patients from non-AD patients. Moreover, Th1 cells (p = 0.037) and Th17 cells (p = 0.001) were positively related to CRP, and Th17 cells (p = 0.039) were also positively associated with D-dimer in Stanford type A AD patients. Furthermore, Th17 cells were elevated in deaths compared with survivors (p = 0.001), also, it could estimate 30-day mortality risk in Stanford type A AD patients with an AUC of 0.741 (95% CI: 0.614-0.867), which was similar to the value of CRP (AUC: 0.771, 95% CI: 0.660-0.882), but lower than the value of D-dimer (AUC:

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“…This effect may be important for the formation of atherosclerotic lesions ( 34 ). Recent studies on human vascular lesions have demonstrated that apoptosis is a prominent feature of both AS and restenosis, which are one of the causes leading to AD ( 35 , 36 ). Therefore, AD may be further aggravated after CTGF induces SMC apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Analysis of Key m6A Modification Related Genes and Immune Infiltrates in Human Aortic Dissection

Yin

Zhang

Guo

et al. 2022

Front. Cardiovasc. Med.

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ObjectiveTo identify the feature of N6-methyladenosine (m6A) methylation modification genes in acute aortic dissection (AAD) and explore their relationships with immune infiltration.MethodsThe GSE52093 dataset including gene expression data from patients with AAD and healthy controls was downloaded from Gene Expression Omnibus (GEO) database in order to obtain the differentially expressed genes (DEGs). The differentially methylated m6A genes were obtained from the GSE147027 dataset. The differentially expressed m6A-related genes were obtained based on the intersection results. Meanwhile, the protein-protein interaction (PPI) network of differentially expressed m6A-related genes was constructed, and hub genes with close relationships in the network were selected. Later, hub genes were verified by using the GSE153434 dataset. Thereafter, the relationships between these genes and immune cells infiltration were analyzed.ResultsA total of 279 differentially expressed m6A-related genes were identified in the GSE52093 and GSE147027 datasets. Among them, 94 genes were up-regulated in aortic dissection (AD), while the remaining 185 were down-regulated. As indicated by Gene Ontology (GO) functional enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses, these genes were mainly associated with extracellular matrix (ECM) and smooth muscle cells (SMCs). The seven hub genes, namely, DDX17, CTGF, FLNA, SPP1, MYH11, ITGA5 and CACNA1C, were all confirmed as the potential biomarkers for AD. According to immune infiltration analysis, it was found that hub genes were related to some immune cells. For instance, DDX17, FLNA and MYH11 were correlated with Macrophages M2.ConclusionOur study identifies hub genes of AD that may serve as the potential biomarkers, illustrates of the molecular mechanism of AD, and provides support for subsequent research and treatment development.

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Aortic Dissection: A Review of the Pathophysiology, Management and Prospective Advances

Cited by 52 publications

References 137 publications

The Correlation and Copathogenesis of Coronary Aortic Sandwich and Renal Cysts

The Correlation and Copathogenesis of Coronary Aortic Sandwich and Renal Cysts

Th1, Th2, and Th17 cells are dysregulated, but only Th17 cells relate to C‐reactive protein, D‐dimer, and mortality risk in Stanford type A aortic dissection patients

Comprehensive Analysis of Key m6A Modification Related Genes and Immune Infiltrates in Human Aortic Dissection

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