Aortic Baroreceptor Activity in Normal and Hypertensive Rabbits

Aars, Harald

doi:10.1111/j.1748-1716.1968.tb03851.x

Cited by 111 publications

(36 citation statements)

References 27 publications

(29 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In case I, cardiac slowing with carotid sinus pressure, and the normal response to the Valsalva manoeuvre, indicated preservation of some baroreceptor function. The baroreceptor sensitivities, taking into account the patient's age and mean arterial blood pressure, were low, but are of the order found by Gribbin et al (1971) in patients with idiopathic hypertension, and could be interpreted as adaptive changes to hypertension, a mechanism which has been described experimentally (McCubbin et al, 1956;Aars, 1968). The baroreceptor sensitivity remained low even when the blood pressure had returned to normal, suggesting that hypertension was not secondary to depressed baroreceptor sensitivity, or vice versa.…”

Section: Discussionmentioning

confidence: 65%

Hypertension and papilloedema in the Guillain-Barre syndrome.

Davidson¹,

Jellinek²

1977

Journal of Neurology, Neurosurgery & Psychiatry

View full text Add to dashboard Cite

SUMMARY Three patients with the Guillain-Barre Syndrome are described, one of whom was relapsing. Hypertension persisted for three to four months in two patients, associated with increased urinary excretion of catecholamines. Baroreceptor sensitivity, although depressed, did not explain the hypertension. It may be due to lesions affecting either central vasomotor control or peripheral sympathetic nerve activity. Two patients had papilloedema. This has been attributed in the literature to defective reabsorption of CSF due to high protein concentration. Normal reabsorption of isotope labelled albumin from the subarachnoid space argues against this explanation in our cases.

show abstract

Section: Discussionmentioning

confidence: 65%

Hypertension and papilloedema in the Guillain-Barre syndrome.

Davidson¹,

Jellinek²

1977

Journal of Neurology, Neurosurgery & Psychiatry

View full text Add to dashboard Cite

show abstract

“…The alteration in the baroreceptor activity could be accounted for by a change in the mechanical properties of the wall of the carotid sinus, since it is known from other studies that baroreceptor activity can be modified by changes in the visco-elastic properties of the arterial wall in which they are situated (Landgren, 1952;Aars, 1968 ;Angell-James, 1971a, 1973a, b, 1974a.…”

Section: Discussionmentioning

confidence: 99%

The effects of carotid endarterectomy on the mechanical properties of the carotid sinus and carotid sinus nerve activity in atherosclerotic patients

Angell‐James

Lumley

1974

British Journal of Surgery

125

View full text Add to dashboard Cite

The hypothesis that instability of blood pressure occurring afrer carotid endarterectomy is related to interference with mechanical properties of the arterial wall in the region of the carotid sinus was investigated in I I patients undergoing carotid surgery for transient ischaemic neurological disturbances. The operative procednre was found to change the mechanical properties of the arterial wall, there being an overall increase in diameter and reduction in distensibility, and these changes were reflected in the recorded change of spontaneous sinus nerve activity and the systemic blood pressure. It is suggested that the sinus nerve and carotid baroreceptor region should be carefully preserved duriizg carotid endarterectomy to prevent reflex postoperative hypertension. Shoidd hypotension occur in the postoperative phase it can be treated by local anaesthesia of the sinus region, anaesthetic blockade being maintained until secondary adaptation of the receptors takes place.

show abstract

“…Abnormalities in baroreflex sensitivity (BRS) in experimental [100, 101] and human hypertension have been demonstrated, with hypertensive subjects exhibiting diminished BRS compared with their normotensive counterparts [102-104]. Additionally, the family history of hypertension is associated with lower BRS in both normotensive and hypertensive offspring [105].…”

Section: Cst Effect On Cardiovascular Systemmentioning

confidence: 99%

Catestatin: A multifunctional peptide from chromogranin A

Mahata

Fung

et al. 2010

Regulatory Peptides

107

View full text Add to dashboard Cite

In 1997, we identified a novel peptide, catestatin (CST: bovine chromogranin A [CHGA] 344-364 : RSMRLSFRARGYGFRGPGLQL; human CHGA : SSMKLSFRARGYGFRGPGPQL), which is a potent inhibitor of nicotinic cholinergic-stimulated catecholamine secretion. CST shows characteristic inhibitory effects on nicotinic cationic (Na + , Ca 2+ ) signal transduction, which are specific to the neuronal nicotinic receptor. Utilizing systematic polymorphism discovery at the human CHGA locus we discovered three human variants of CST: G 364 S, P 370 L, and R 374 Q that showed differential potencies towards inhibition of catecholamine secretion. In humans, CHGA is elevated and its processing to CST is diminished in hypertension. Diminished CST is observed not only in hypertensive individuals but also early-normotensive offspring of patients with hypertension, suggesting that an early deficiency of CST might play a pathogenic role in the subsequent development of the disease. Consistent with human findings, prevention of endogenous CST expression by targeted ablation (knockout) of the mouse Chga locus (Chga-KO) resulted in severe hypertension that can be "rescued" specifically by replacement of the CST peptide. CST acts directly on the heart to inhibit the inotropic and lusitropic properties of the rodent heart and also acts as a potent vasodilator in rat and human. While the G 364 S CST variant caused profound changes in human autonomic activity and seemed to reduce risk of developing hypertension, CST replacement rescued Chga-KO mice from dampened baroreflex sensitivity. In addition, CST has been shown to induce chemotaxis and acts as an antimicrobial as well as an antimalarial peptide. The present review summarizes these multiple actions of CST.

show abstract

Aortic Baroreceptor Activity in Normal and Hypertensive Rabbits

Cited by 111 publications

References 27 publications

Hypertension and papilloedema in the Guillain-Barre syndrome.

Hypertension and papilloedema in the Guillain-Barre syndrome.

The effects of carotid endarterectomy on the mechanical properties of the carotid sinus and carotid sinus nerve activity in atherosclerotic patients

Catestatin: A multifunctional peptide from chromogranin A

Contact Info

Product

Resources

About