Aortic Arch Geometry and Exercise-Induced Hypertension in Aortic Coarctation

Effects of Ramipril on Endothelial Function and the Expression of Proinflammatory Cytokines and Adhesion Molecules in Young Normotensive Subjects With Successfully Repaired Coarctation of Aorta

“…However, the role of the aortic arc geometry (classified as normal, Gothic, and Crenel) does not seem to be related to the development of exerciseinduced hypertension in these subjects (14). On the other hand, the very first reports about the impact of vasoreactivity on the development of post-SCR hypertension suggested that SCR patients with persisting postoperative hypertension had greater vasoreactivity in response to norepinephrine compared with those with normal blood pressure (15).…”

Impact of genomic polymorphism on arterial hypertension after aortic coarctation repair

“…Low grade restenosis [1,2] is the most obvious reason. The geometry of the aortic arch might have an impact on the incidence of hypertension after coarctation repair [3,4], however, a recent study could not confirm this coincidence [5]. Recent physiologic studies focus on inborn [6] and acquired [7] defects in the wall of the aorta with an increased rate of elastic fiber fragmentation, fibrosis and cystic medial necrosis [8] that lead to an increased stiffness of the aorta [6,[9][10][11][12], which results in a blunted baroreceptor reflex [13,14], in an increased brachial pulse wave velocity [7,15], and an increased carotid intima-media thickness even in children [16].…”

Mechanical Characterization of the Human Aorta: Experiments, Modeling and Simulation

“…Moreover, the knowledge of the rupture stress and strain in this artery under normal, hypertension and severe (e.g., automobile accidents or cardiovascular problems) physiological conditions is also a relevant area of current interest [24,33,87]. The aortic arch motion is linked to that of the heart left ventricle through the aortic root.…”

“…Three types of mechanical actions causing the blunt traumatic aortic rupture have been identified: stretching, intravascular pressure and water-hammer effect [34,87]. In particular, hypertension at rest or during effort in patients with aortic arch coarctation has been studied in cases with successful repair or mild degree of obstruction [24]. Moreover, impact-sled tests with human cadaver thoraces have been carried out to investigate the aortic injury mechanism caused by the effect of acceleration that induces a differential motion of the aortic arch relative to the heart and its neighboring vessels [35].…”