Aorta-to-Coronary-Artery Vein Bypass Graft for Coronary Artery Occlusive Disease

Urschel, Harold C.; Miller, Ervin R.; Razzuk, Maruf A.; Alvares, Jose Filipe; McNamara, J. Judson; Paulson, Donald L.

doi:10.1016/s0003-4975(10)66218-2

Cited by 26 publications

(9 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The characterization of a specific chymase inhibitor, SucVal-Pro-Phe P (OPh) 2 , was reported by Oleksyszyn and Powers. 16 The half-degradative time of the chymase inhibitor is Ϸ20 hours in human plasma.…”

Section: Discussionmentioning

confidence: 97%

“…A specific chymase inhibitor, Suc-Val-Pro-Phe P (OPh) 2 , was a gift from Dr Oleksyszyn, Akoslogic Inc, Mass. 16 cDNA probes used were as follows: rat transforming growth factor-␤ 1 (TGF-␤ 1 ) cDNA (a 1.0-kb HindIII/XbaI fragment) 17 ; rat fibronectin cDNA (a 0.27-kb HindIII/EcoRI fragment) 18 ; rat ␣ 1 (I) collagen cDNA (a 1.3-kb PstI/BamHI fragment) 19 ; mouse ␣ 1 (III) collagen cDNA (a 1.8-kb EcoRI/EcoRI fragment) 20 ; and rat cDNA for vascular endothelial growth factor (VEGF).…”

Section: Drugs and Cdna Probesmentioning

confidence: 99%

“…1,2 The internal thoracic artery (ITA) and saphenous vein (SV) have frequently been used as coronary artery bypass conduits. The clinical benefits are gradually lost, however, and graft function deteriorates, resulting in recurrence of clinical symptoms.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Significance of Chymase-Dependent Angiotensin II–Forming Pathway in the Development of Vascular Proliferation

et al. 2001

View full text Add to dashboard Cite

Background Vascular tissues of humans and dogs contain chymase as an angiotensin II–forming enzyme. In this study, we investigated whether chymase-dependent angiotensin II formation plays a crucial role in the development of vascular proliferation in dog grafted veins. Methods and Results The right external jugular vein of dogs was grafted to the ipsilateral carotid artery. As a control group, the right external jugular veins in dogs that had not received grafts were used. In the chymase inhibitor–treated group, the vein was infiltrated with 10 μmol/L Suc-Val-Pro-Phe P (OPh) 2 and was grafted to the carotid artery. In the placebo-treated group, ACE activity in the grafted veins was significantly lower than that in the control veins up to 7 days after the operation, whereas chymase activity was increased significantly. After 7 days, the mRNA levels of collagen I, collagen III, and fibronectin, all of which are induced by an increase of angiotensin II action, were significantly increased in the grafted veins, and the intima-media ratio of the grafted veins was also increased. In the chymase inhibitor–treated group, the chymase activity in the grafted veins 7 days after the operation was suppressed to 12.1%. The elevated mRNA levels of fibronectin, collagen I, and collagen III in the grafted veins were significantly suppressed by treatment with the chymase inhibitor, and the intima-media ratio was also decreased significantly. Conclusions We demonstrate for the first time that chymase-dependent angiotensin II formation plays an important role in the development of vascular proliferation in the grafted veins.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Drugs and Cdna Probesmentioning

confidence: 99%

See 1 more Smart Citation

Significance of Chymase-Dependent Angiotensin II–Forming Pathway in the Development of Vascular Proliferation

et al. 2001

View full text Add to dashboard Cite

show abstract

“…Coronary artery bypass grafting is offered to patients with ischemic heart disease (24,25). The internal thoracic artery and saphenous vein have been frequently used as coronary artery bypass conduits.…”

Section: Discussionmentioning

confidence: 99%

A Single Treatment With a Specific Chymase Inhibitor, TY-51184, Prevents Vascular Proliferation in Canine Grafted Veins

2004

View full text Add to dashboard Cite

Abstract. In this study, we evaluated whether a specific chymase inhibitor, TY-51184 (2-[4-(5-fluoro-3-methylbenzo[b]thiophen-2-yl)sulfonamido-3-methanesulfonylphenyl]oxazole-4-carboxylicacid), prevents the vascular proliferation in canine grafted veins. In the placebo-and chymase inhibitor-treated groups, the external jugular vein was infiltrated with saline and 10 mM TY-51184, respectively, and then it was grafted to the ipsilateral carotid artery. The non-surgical dogs were used as the control group. By 28 days after grafting, the chymase and ACE activities were significantly increased in the injured arteries. TY-51184 significantly reduced the chymase activity in the grafted veins, while it did not affect the ACE activity. The intimal areas in the placebo-and TY-51184-treated groups were 3.32 ± 0.16 and 1.96 ± 0.52 mm 2 , respectively, and this difference was significant. The ratios of intimal area to medial area in the placebo-and TY-51184-treated groups were 66.8 ± 3.5% and 34.9 ± 9.2%, respectively, and this difference was also significant. There was a significant relationship between vascular proliferation and chymase activity, but not ACE activity. In this study, we demonstrated that a single treatment with a specific chymase inhibitor, TY-51184, could prevent the vascular proliferation in canine grafted veins.

show abstract

“…Coronary artery bypass grafting is offered to patients with ischemic heart disease (16,17). The internal thoracic artery (ITA) and saphenous vein (SV) have been frequently used as coronary artery bypass conduits.…”

Section: Ita Vs Sv In Graftsmentioning

confidence: 99%

Development and Application of Chymase Inhibitors: Effect of Chymase Inhibitor on Vascular Proliferation

Miyazaki

2002

Japanese Journal of Pharmacology

View full text Add to dashboard Cite

ABSTRACT-In vascular tissues, angiotensin II is potentially cleaved from angiotensin I by chymase and angiotensin-converting enzyme (ACE). In the normal state, vascular ACE regulates local angiotensin II formation and plays a crucial role in the regulation of blood pressure, whereas chymase is stored in mast cells and has no enzymatic activity. Chymase is activated immediately upon its release into the extracellular matrix in vascular tissues after mast cells have been activated by stimuli such as vessel injury by grafting or a balloon catheter. In dog grafted veins, chymase activity is increased, and the vascular proliferation is suppressed by either a chymase inhibitor or an angiotensin II receptor blocker. After balloon injury in dog vessels, chymase activity is significantly increased in the injured artery, and a chymase inhibitor is effective in preventing the vascular proliferation, but an ACE inhibitor is ineffective. Chymase plays an important role in the development of vascular proliferation via the induction of local angiotensin II formation in injured vessels.

show abstract

Aorta-to-Coronary-Artery Vein Bypass Graft for Coronary Artery Occlusive Disease

Cited by 26 publications

References 9 publications

Significance of Chymase-Dependent Angiotensin II–Forming Pathway in the Development of Vascular Proliferation

Significance of Chymase-Dependent Angiotensin II–Forming Pathway in the Development of Vascular Proliferation

A Single Treatment With a Specific Chymase Inhibitor, TY-51184, Prevents Vascular Proliferation in Canine Grafted Veins

Development and Application of Chymase Inhibitors: Effect of Chymase Inhibitor on Vascular Proliferation

Contact Info

Product

Resources

About