AOPP and its relations with selected markers of oxidative/antioxidative system in type 2 diabetes mellitus

Piwowar, Agnieszka; Knapik-Kordecka, Maria; Warwas, Maria

doi:10.1016/j.diabres.2006.12.007

Cited by 83 publications

(70 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…ese data are in agreement with those of other authors [39][40][41][42]. ese ndings suggest that oxidative protein damage begins in early stages of diabetes and continues to increase as the disease progresses and that AOPP is also a valid biomarker for assessing oxidative stress in diabetes.…”

Section: Discussionsupporting

confidence: 82%

See 1 more Smart Citation

Oxidative lipid, protein, and DNA damage as oxidative stress markers in vascular complications of diabetes mellitus

Tabak¹,

Gelışgen²,

Erman³

et al. 2011

CIM

111

View full text Add to dashboard Cite

Oxidative lipid, protein, and DNA damage as oxidative stress markers in vascular complications of diabetes mellitus AbstractPurpose: e purpose of this study was to determine the e ects of diabetic complications on oxidation of proteins, lipids, and DNA and to investigate the relationship between oxidative damage markers and clinical parameters.Methods: e study group consisted of 69 type 2 diabetic patients (20 patients without complication, 49 patients with complication) who attended internal medicine outpatient clinics of Istanbul Education and Research Hospital and 19 healthy control subjects. In serum samples of both diabetic patients and healthy subjects, 8-hydroxy-2'deoxyguanosine (8-OHdG), as a marker of oxidative DNA damage, N ε -(hexanoyl)lysine (HEL) and 15-F2t-iso-prostaglandin (15-F2t-IsoP). as products of lipooxidative damage, advanced oxidation protein products (AOPP), as markers of protein damage, and paraoxonase1 (PON1) as antioxidant were studied.Results: 15-F2t-IsoP (p<0.005) and AOPP (p<0.001) levels were signi cantly higher in diabetic group than control group while there were no signi cant di erences in levels of 8-OHdG and HEL between the two groups. AOPP (p<0.001) and 8-OHdG (p<0.001) were signi cantly higher in diabetic group with complications compared to diabetic group without complications.Conclusions: Increased formation of free radicals and oxidative stress, under conditions of hyperglycaemia, is one of the probable causes for evolution of complications in diabetes mellitus. Our study supports the hypothesis that oxidant/antioxidant balance is disturbed in diabetic patients.

show abstract

Section: Discussionsupporting

confidence: 82%

“…ese data con rm the previous observations [45][46][47][48][49] of low PON activity in type 2 diabetes. DM is accompanied by the development of oxidative protein damage as evaluated by an increase in the circulating oxidized proteins [40,42]. is change could be related to an increased risk of endothelial damage.…”

Section: Discussionmentioning

confidence: 99%

Oxidative lipid, protein, and DNA damage as oxidative stress markers in vascular complications of diabetes mellitus

Tabak¹,

Gelışgen²,

Erman³

et al. 2011

CIM

111

View full text Add to dashboard Cite

show abstract

“…Elevated plasma levels of AOPP have been detected both in patients on hemodialysis (HD) and peritoneal dialysis (PD), as well as in patients with coronary artery disease and diabetes (14)(15)(16). As plasma triglycerides interfere with the method of quantifying AOPP, leading to an over-estimation of AOPP values (17), a modified AOPP (mAOPP) assay, in which triglycerides are removed by precipitation before analysis, was developed and applied in uremic patients (18).…”

mentioning

confidence: 99%

Increased Levels of Modified Advanced Oxidation Protein Products are Associated with Central and Peripheral Blood Pressure in Peritoneal Dialysis Patients

Cabezas-Rodríguez

Qureshi

et al. 2015

Perit Dial Int

View full text Add to dashboard Cite

“…Several studies has pointed out that advanced oxidative protein products and oxidative stress markers increase in adult subjects with type 2 DM with and without micro/macrovascular complications [17,18]. GSH is present in all mammalian tissues at 1-10 mM concentrations (highest concentrations in liver) as the most abundant nonprotein thiol that defends against oxidative stress [19].…”

Section: Discussionmentioning

confidence: 99%

Estimation of plasma glutathione levels in NIDDM patients with and without cardiovascular disease

Vani

Hemanthkumar

2015

Int Jour of Biomed Res

View full text Add to dashboard Cite

Diabetes mellitus is a group of metabolic derangements characterised by hyperglycemia resulting from defective insulin secretion or action or both. Persistent hyperglycemia generates reactive oxygen species causing oxidative damage to cells and various biomolecules. In this study the levels of reduced glutathione antioxidant were estimated in NIDDM patients with cardiovascular disease (n=50) by HPLC method and compared to healthy controls (n=50). The results indicated that plasma glutathione levels are significantly decreased showing that antioxidant defence is lowered in diabetic patients with cardiovascular complications.

show abstract

AOPP and its relations with selected markers of oxidative/antioxidative system in type 2 diabetes mellitus

Cited by 83 publications

References 27 publications

Oxidative lipid, protein, and DNA damage as oxidative stress markers in vascular complications of diabetes mellitus

Oxidative lipid, protein, and DNA damage as oxidative stress markers in vascular complications of diabetes mellitus

Increased Levels of Modified Advanced Oxidation Protein Products are Associated with Central and Peripheral Blood Pressure in Peritoneal Dialysis Patients

Estimation of plasma glutathione levels in NIDDM patients with and without cardiovascular disease

Contact Info

Product

Resources

About