Anxiolytic property of estrogen related to the changes of the monoamine levels in various brain regions of ovariectomized rats

Pandaranandaka, Jantarima; Poonyachoti, Sutthasinee; Kalandakanond-Thongsong, Sarinee

doi:10.1016/j.physbeh.2006.02.002

Cited by 70 publications

(34 citation statements)

References 73 publications

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“…In this study, OVX females in the estrogen supplementation group were administered daily injections of 17β-estradiol (10 µg/kg, s.c.) for four weeks following OVX. This treatment paradigm resulted in an increased time spent in the open arms of the EPM indicative of the anxiolytic properties of estrogen (Pandaranandaka et al, 2006). Chronic hormone replacement may enhance the physiological relevance of using an OVX model for the study of estrogen’s effect on sex difference in cocaine addiction.…”

Section: Discussionmentioning

confidence: 99%

Cocaine withdrawal‐induced anxiety in females: Impact of circulating estrogen and potential use of delta‐opioid receptor agonists for treatment

Ambrose-Lanci

Sterling

Bockstaele

2009

J of Neuroscience Research

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Sex differences in cocaine addiction warrants further research focused on examining the growing population of female cocaine addicts. As demonstrated in both clinical and preclinical research, females are more susceptible to drug relapse with anxiety being a contributing factor. In support of this, a recent clinical study from our laboratory highlights the importance of menstrual cycle phase and anxiety at treatment admission for cocaine addiction on treatment retention. In support of these trends in the clinical population, the purpose of the present study was to design an animal model to directly test the role of circulating hormone levels during cocaine withdrawal. To directly measure the influence of estrogen on anxiety-like behavior during early stages of withdrawal, both ovariectomized and intact female rodent models were employed. The elevated-plus maze and elevated-zero maze were used to assess anxiety-like behavior. Recent evidence in male rodents highlights a potential role for the delta opioid-receptor (DOR) system in the modulation of cocaine withdrawal-induced anxiety. In addition to the evaluation of hormonal effects, a potential anxiolytic specific for DOR was tested for its efficacy in females withdrawn from cocaine. Our results support the use of DOR agonists as a potential anxiolytic in females and highlight the importance of estrogen and other circulating hormones during all phases of cocaine addiction.

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Section: Discussionmentioning

confidence: 99%

Cocaine withdrawal‐induced anxiety in females: Impact of circulating estrogen and potential use of delta‐opioid receptor agonists for treatment

Ambrose-Lanci

Sterling

Bockstaele

2009

J of Neuroscience Research

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“…Another approach involves ovariectomy (OVX) procedures and testing the female rats following replacement of key ovarian hormones, such as estrogen and/or progesterone. Special consideration must be taken when employing OVX procedures in rodent models of motivational behavior, given that OVX procedures alter anxiety-like behavior (Pandaranandaka et al, 2006) and suppress dopamine systems (Bosse and Di Paolo, 1996; Garcia-Munoz et al, 1989; Morissette and Di Paolo, 1993; Russo et al, 2003). Nicotine has also been shown to facilitate learning tasks to a greater extent in females as compared to males (Taylor and Maloney, 2010).…”

Section: Pre-clinical Rodent Models Of Nicotine Reward and Aversivmentioning

confidence: 99%

A mechanistic hypothesis of the factors that enhance vulnerability to nicotine use in females

O’Dell

Torres

2014

Neuropharmacology

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Women are particularly more vulnerable to tobacco use than men. This review proposes a unifying hypothesis that females experience greater rewarding effects of nicotine and more intense stress produced by withdrawal than males. We also provide a neural framework whereby estrogen promotes greater rewarding effects of nicotine in females via enhanced dopamine release in the nucleus accumbens (NAcc). During withdrawal, we suggest that corticotropin-releasing factor (CRF) stress systems are sensitized and promote a greater suppression of dopamine release in the NAcc of females versus males. Taken together, females display enhanced nicotine reward via estrogen and amplified effects of withdrawal via stress systems. Although this framework focuses on sex differences in adult rats, it is also applied to adolescent females who display enhanced rewarding effects of nicotine, but reduced effects of withdrawal from this drug. Since females experience strong rewarding effects of nicotine, a clinical implication of our hypothesis is that specific strategies to prevent smoking initiation among females are critical. Also, anxiolytic medications may be more effective in females that experience intense stress during withdrawal. Furthermore, medications that target withdrawal should not be applied in a unilateral manner across age and sex, given that nicotine withdrawal is lower during adolescence. This review highlights key factors that promote nicotine use in females, and future studies on sex-dependent interactions of stress and reward systems are needed to test our mechanistic hypotheses. Future studies in this area will have important translational value toward reducing health disparities produced by nicotine use in females.

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“…[115] Along these lines, augmentation treatment with an NRI for patients with partial response to an SSRI is commonly used when treating MDD. [129,130] Several studies have shown that SNRIs that elevate both 5-HT and NE (e.g., venlafaxine and duloxetine) have been shown to be efficacious in treating anxious depression. [63,[131][132][133] The duration required for these treatments to achieve remission depends highly on successfully minimizing the residual symptoms.…”

Section: Duration Of Treatmentmentioning

confidence: 99%

Current perspectives of the roles of the central norepinephrine system in anxiety and depression

et al. 2010

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Norepinephrine (NE) is a major monoamine neurotransmitter that has widespread effects across multiple brain areas to regulate arousal and stress responses. The underlying function of the NE cortical system is to balance vigilance/scanning behavior with focused attention on novel environmental stimuli and the state of arousal. The central NE system is involved intrinsically with the stress response system, and dysregulation within the NE system has been implicated in the pathogenesis of anxiety and depressive disorders. Central NE activity paradoxically has either anxiogenic or anxiolytic effects, depending on whether the time course of the stress is acute or chronic, whether the stress is predictable or unpredictable, and which underlying brain regions are affected. Under conditions of chronic stress, NE system activity dysregulation of the hypothalamic-pituitary-adrenal system may turn a homeostatic stress response into a pathological stress response. Data suggest that the NE interplay with the serotonin system may exert neurobiological normalization of the pathophysiological state of anxious depression. Accordingly, pharmacological interventions targeting the NE system can result in anxiolytic, rather than anxiogenic, outcomes when used to treat patients with anxiety and depression. Depression and Anxiety 27:339-350, 2010. r r

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Anxiolytic property of estrogen related to the changes of the monoamine levels in various brain regions of ovariectomized rats

Cited by 70 publications

References 73 publications

Cocaine withdrawal‐induced anxiety in females: Impact of circulating estrogen and potential use of delta‐opioid receptor agonists for treatment

Cocaine withdrawal‐induced anxiety in females: Impact of circulating estrogen and potential use of delta‐opioid receptor agonists for treatment

A mechanistic hypothesis of the factors that enhance vulnerability to nicotine use in females

Current perspectives of the roles of the central norepinephrine system in anxiety and depression

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