Anxiolytic-like effects of DOI microinjections into the hippocampus (but not the amygdala nor the PAG) in the mice four plates test

Massé, Fabienne; Petit-Demoulière, Benoît; Dubois, I.; Hascoët, Martine; Bourin, Michel

doi:10.1016/j.bbr.2007.11.005

Cited by 12 publications

(10 citation statements)

References 56 publications

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“…Their results, as well as a number of articles cited showing the expression of 5-HT 2A receptors on GABA neurons, led these authors to hypothesize that 5-HT 2A receptor activation on GABA neurons increases GABA release, which stimulates postsynaptic GABA A receptors. In a separate study, Masse et al (2008) microinjected DOI into the mouse hippocampus, amygdala, or periaqueductal gray matter (PAG) and then immediately subjected the mice to the four-plates test to assess anxiety. They demonstrated that DOI produced an anxiolytic effect only when microinjected into the hippocampus, but not into the amygdala or PAG.…”

Section: A Alleviation Of Anxiety and Depression In Life-threateningmentioning

confidence: 99%

Psychedelics

2016

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Section: A Alleviation Of Anxiety and Depression In Life-threateningmentioning

confidence: 99%

Psychedelics

2016

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“…For example, 5‐HT1A antagonist (Griebel et al. 2000), 5‐HT2A/C and 5‐HT2B agonists (Masse et al. 2008) and 5‐HT3 partial agonist (Delagrange et al.…”

Section: Discussionmentioning

confidence: 99%

The deletion of STOP/MAP6 protein in mice triggers highly altered mood and impaired cognitive performances

Fournet¹,

Schweitzer²,

Chevarin³

et al. 2012

Journal of Neurochemistry

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J. Neurochem. (2012) 121, 99–114. Abstract The microtubule‐associated Stable Tubulie Only Polypeptide (STOP; also known as MAP6) protein plays a key role in neuron architecture and synaptic plasticity, the dysfunctions of which are thought to be implicated in the pathophysiology of psychiatric diseases. The deletion of STOP in mice leads to severe disorders reminiscent of several schizophrenia‐like symptoms, which are also associated with differential alterations of the serotonergic tone in somas versus terminals. In STOP knockout (KO) compared with wild‐type mice, serotonin (5‐HT) markers are found to be markedly accumulated in the raphe nuclei and, in contrast, deeply depleted in all serotonergic projection areas. In the present study, we carefully examined whether the 5‐HT imbalance would lead to behavioral consequences evocative of mood and/or cognitive disorders. We showed that STOP KO mice exhibited depression‐like behavior, associated with a decreased anxiety‐status in validated paradigms. In addition, although STOP KO mice had a preserved very short‐term memory, they failed to perform well in all other learning and memory tasks. We also showed that STOP KO mice exhibited regional imbalance of the norepinephrine tone as observed for 5‐HT. As a consequence, mutant mice were hypersensitive to acute antidepressants with different selectivity. Altogether, these data indicate that the deletion of STOP protein in mice caused deep alterations in mood and cognitive performances and that STOP protein might have a crucial role in the 5‐HT and norepinephrine networks development.

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“…Masse et al [24] and de Paula Soares et al [25] have reported that the stimulation of the 5-HT 2A/2C receptor in specific brain regions causes anxiolytic-like effect in animal models.…”

Section: Discussionmentioning

confidence: 99%

“…The corticolimbic distribution of the 5-HT 2A receptors might be critically involved in the neuropathology and treatment of a variety of psychiatric disorders including anxiety [79141516171819]. Various studies have indicated anxiolytic-like actions of 5-HT 2 receptor agonists and anxiogenic-like effects of 5-HT 2 receptor antagonists in diverse animal models [16202122232425]. …”

Section: Introductionmentioning

confidence: 99%

Hippocampal serotonin-2A receptor-immunoreactive neurons density increases after testosterone therapy in the gonadectomized male mice

et al. 2016

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The change of steroid levels may also exert different modulatory effects on the number and class of serotonin receptors present in the plasma membrane. The effects of chronic treatment of testosterone for anxiety were examined and expression of 5-HT2A serotonergic receptor, neuron, astrocyte, and dark neuron density in the hippocampus of gonadectomized male mice was determined. Thirty-six adult male NMRI mice were randomly divided into six groups: intact-no testosterone treatment (No T), gonadectomy (GDX)-No T, GDX-Vehicle, GDX-6.25 mg/kg testosterone (T), GDX-12.5 mg/kg T, and GDX-25 mg/kg T. Anxiety-related behavior was evaluated using elevated plus maze apparatus. The animals were anesthetized after 48 hours after behavioral testing, and decapitated and micron slices were prepared for immunohistochemical as well as histopathological assessment. Subcutaneous injection of testosterone (25 mg/kg) may induce anxiogenic-like behavior in male mice. In addition, immunohistochemical data reveal reduced expression of 5-HT2A serotonergic receptor after gonadectomy in all areas of the hippocampus. However, treatment with testosterone could increase the mean number of dark neurons as well as immunoreactive neurons in CA1 and CA3 area, dose dependently. The density of 5-HT2A receptor-immunoreactive neurons may play a crucial role in the induction of anxiety like behavior. As reduction in such receptor expression have shown to significantly enhance anxiety behaviors. However, replacement of testosterone dose dependently enhances the number of 5-HT2A receptor-immunoreactive neurons and interestingly also reduced anxiety like behaviors.

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Anxiolytic-like effects of DOI microinjections into the hippocampus (but not the amygdala nor the PAG) in the mice four plates test

Cited by 12 publications

References 56 publications

Psychedelics

Psychedelics

The deletion of STOP/MAP6 protein in mice triggers highly altered mood and impaired cognitive performances

Hippocampal serotonin-2A receptor-immunoreactive neurons density increases after testosterone therapy in the gonadectomized male mice

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