Anxiolytic-like effect of sweet orange aroma in Wistar rats

Faturi, Claudia de Brito; Leite, José Roberto; Alves, Péricles Barreto; Canton, Adriane Conte; Teixeira-Silva, Flávia

doi:10.1016/j.pnpbp.2010.02.020

Cited by 126 publications

(96 citation statements)

References 27 publications

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“…Besides EOCA and EOCL, other EOs that showed anxiolytic-like effects in animal models, such as C. x aurantium, C. x reticulata, Foeniculum vulgare and Lippia alba (limonene-carvone chemotype), have limonene as a major component (Gargano et al, 2008;Faturi et al, 2010;Saiyudthong, Marsden, 2011;Hatano et al, 2012;Mesfin et al, 2014). Limonene directly binds to the adenosine A 2A receptor, which may induce sedative effects (Park et al, 2011) and also demonstrated direct vasorelaxant effects (Kang et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…EOs of plants of this genus have been used in the treatment of anxiety or insomnia in humans (Lehrner et al, 2005), and oils of different species have shown promising results in preclinical trials using rodents. The most noteworthy among these are C. x sinensis (Faturi et al, 2010) and C. x limon (Ceccarelli et al, 2004) in rats, and C. x latifolia (Gargano et al, 2008) and C. x aurantium (Carvalho-Freitas, Costa, 2002;Pultrini et al, 2006) in mice. Sedative and anxiolytic-like effects have been described for the EO obtained from the peel of Citrus x aurantium in rats and mice (Leite et al, 2008;Costa et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Essential oils from Citrus x aurantium and Citrus x latifolia (Rutaceae) have anesthetic activity and are effective in reducing ion loss in silver catfish ( Rhamdia quelen )

et al. 2018

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This study investigated the anesthetic effect of the essential oils (EOs) from the peel of Citrus x aurantium (EOCA) and Citrus x latifolia (EOCL) on silver catfish Rhamdia quelen. Fish were exposed to different concentrations of EOCA and EOCL to determine time of anesthesia induction and recovery. Induction of anesthesia was observed in all fish exposed to 400, 600 or 800 μL L−1 EOCA and 300, 400 or 500 μL L−1 EOCL. Another group of fish were exposed for 8 h to 50, 100, or 200 μL L−1 of either EOs. Overall, fish exposed to ethanol and both EOs presented higher ventilatory frequencies (VF) than the control group throughout the 8 h of exposure. Net ion (Na+, K+ and Cl−) effluxes and ammonia excretion were significantly lower in fish exposed to 50, 100 or 200 μL L−1 of either EOs compared to control fish. Mortality was 37% in fish exposed to 200 μL L−1 of either EOs after 8 h. These findings suggest that EOCA and EOCL are useful anesthetics and sedatives for Rhamdia quelen, but their usefulness as alternatives to reduce stress in fish transportation at the lower concentrations tested (50-100 µL L−1) deserves further study.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Essential oils from Citrus x aurantium and Citrus x latifolia (Rutaceae) have anesthetic activity and are effective in reducing ion loss in silver catfish ( Rhamdia quelen )

et al. 2018

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“…Moreover, the sweet orange aroma have been reported to be anxiolytic-like for Wistar rats [89]. (+)-limonene can be used as an antianxiety agent in aromatherapy as demonstrated by an additional study carried out by Lima et al [90], showing that (+)-limonene administered by inhalation exerted anxiolytic-like effects in the elevated plus maze test, with a pharmacological potency stronger than essential oil of C. aurantium and that this effect was not related to benzodiazepine receptors.…”

Section: Aromatherapymentioning

confidence: 99%

Current and Potential Use of Citrus Essential Oils

Palazzolo¹,

Laudicina²,

Germanà

2013

COC

151

102

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Abstract:Since the Middle Ages, citrus essential oils (EOs) have been widely used for their bactericidal, virucidal, fungicidal, antiparasitical, insecticidal, medicinal and cosmetic proprieties. Also nowadays, they find important applications in pharmaceutical, sanitary, cosmetic, agricultural and food industries. The best method to extract EOs from citrus plant tissue is steam distillation because of a variety of extracted volatile molecules such as terpenes and terpenoids, phenol-derived aromatic components and aliphatic components. In vitro physicochemical assays classify most of them as antioxidants.

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“…It is conceivable that sweet orange oil might induce relaxation through psychological effects and decrease sympathetic nervous system activity. In experimental study on Wister rats, anxiolytic effects were observed using sweet orange 11) . The effect of some essential oils, including sweet orange oil, and lavender oil were reported to reduce anxiety through use as aromatherapy 12,13) .…”

Section: Discussionmentioning

confidence: 99%

The Influence of Olfactory Stimulation by Essential Oils on Salivary Alpha-Amylase Activity and State Anxiety Level

Nagata

Miyashita

Mori

2013

JJCAM

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[ABSTRACT] It is considered that olfactory stimulation by fragrance inhalation is one of the methods of relaxation. We examined the possibility by using fragrance inhalation essential oils, such as sweet orange oil and peppermint oil. We measured salivary alpha-amylase activity and state anxiety levels in undergraduate students before and after inhalation. Salivary alpha-amylase activity levels have been utilized to assess the sympathetic nervous activity. Our results indicate that both salivary alphaamylase activity and state anxiety levels are significantly reduced after fragrance inhalation of the sweet orange oil. Consequently, our research suggests that sweet orange essential oil has a relaxation effect.

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Anxiolytic-like effect of sweet orange aroma in Wistar rats

Cited by 126 publications

References 27 publications

Essential oils from Citrus x aurantium and Citrus x latifolia (Rutaceae) have anesthetic activity and are effective in reducing ion loss in silver catfish ( Rhamdia quelen )

Essential oils from Citrus x aurantium and Citrus x latifolia (Rutaceae) have anesthetic activity and are effective in reducing ion loss in silver catfish ( Rhamdia quelen )

Current and Potential Use of Citrus Essential Oils

The Influence of Olfactory Stimulation by Essential Oils on Salivary Alpha-Amylase Activity and State Anxiety Level

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