Anxiolytic-like effect of succinic acid: A possible GABAergic intervention

Mia, Md. Nayem; Smrity, Shanita Zaman; Bappi, Mehedi Hasan; Kamli, Hossam; Islam, Tawhida; Prottay, Abdullah Al Shamsh; Akbor, Md. Showkoth; Latif, Md. Abdul; Islam, Shoriful; Bhakta, Kushal; Shill, Manik Chandra; Sousa, Francisco Claudeni Pereira de; Luna, Gilberto de; Coutinho, Henrique Douglas Melo; Islam, Muhammad Torequl

doi:10.1016/j.fbio.2023.103044

Cited by 5 publications

(2 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Findings of docking show how strongly a target molecule is bound to its catalytic domain. The characteristics of the ligands in the initial target protein grids for these active binding regions of the target protein were examined using PyMOL (v2.50, accessed on May 11, 2023) (Kamli et al, 2023; Lill & Danielson, 2011) and BIOVIA Discovery Studio (v21.1.0, Dassault Systemes, accessed on November 10, 2022) (Chaturvedi et al, 2021; Mia et al, 2023).…”

Section: Methodsmentioning

confidence: 99%

Quercetin increases the antidepressant‐like effects of sclareol and antagonizes diazepam in thiopental sodium‐induced sleeping mice: A possible GABAergic transmission intervention

Bappi,

Mia,

Ansari

et al. 2024

Phytotherapy Research

Self Cite

View full text Add to dashboard Cite

Quercetin is the most common polyphenolic flavonoid present in fruits and vegetables demonstrating versatile health‐promoting effects. This study aimed to examine the effects of quercetin (QR) and sclareol (SCL) on the thiopental sodium (TS)‐induced sleeping and forced swimming test (FST) mouse models. SCL (1, 5, and 10 mg/kg, p.o.) or QR (50 mg/kg, p.o.) and/or diazepam (DZP) (3 mg/kg, i.p.) were employed. After 30 min of TS induction, individual or combined effects on the animals were checked. In the FST test, the animals were subjected to forced swimming after 30 min of administration of the test and/or controls for 5 min. In this case, immobility time was measured. In silico studies were conducted to evaluate the involvement of GABA receptors. SCL (5 and 10 mg/kg) significantly increased the latency and decreased sleeping time compared to the control in the TS‐induced sleeping time study. DZP (3 mg/kg) showed a sedative‐like effect in animals in both sleeping and FST studies. QR (50 mg/kg) exhibited a similar pattern of activity as SCL. However, its effects were more prominent than those of SCL groups. SCL (10 mg/kg) altered the DZP‐3‐mediated effects. SCL‐10 co‐treated with QR‐50 significantly (p < 0.05) increased the latency and decreased sleep time and immobility time, suggesting possible synergistic antidepressant‐like effects. In silico studies revealed that SCL and QR demonstrated better binding affinities with GABAA receptor, especially α2, α3, and α5 subunits. Both compounds also exhibited good ADMET and drug‐like properties. In animal studies, the both compounds worked synergistically to provide antidepressant‐like effects in a slightly different fashion. As a conclusion, the combined administration of SCL and QR may be used in upcoming neurological clinical trials, according to in vivo and in silico findings. However, additional investigation is necessary to verify this behavior and clarify the potential mechanism of action.

show abstract

Section: Methodsmentioning

confidence: 99%

Quercetin increases the antidepressant‐like effects of sclareol and antagonizes diazepam in thiopental sodium‐induced sleeping mice: A possible GABAergic transmission intervention

Bappi,

Mia,

Ansari

et al. 2024

Phytotherapy Research

Self Cite

View full text Add to dashboard Cite

show abstract

“…Input files for docking were prepared by setting appropriate docking algorithms and parameters. Ligands were docked with prepared protein structures, and the docking results were analyzed using PyMOL (version 2.5.5, Schrodinger Inc., New York, NY, United States) and BIOVIA Discovery Studio ( Mia et al, 2023 ; Prottay et al, 2024 ). The docking analysis involved the visualization of ligand-protein interactions, the calculation of binding energy and other parameters, and the identification of potential binding sites and key amino acid residues.…”

Section: Methodsmentioning

confidence: 99%

Anti-inflammatory activity of d-pinitol possibly through inhibiting COX-2 enzyme: in vivo and in silico studies

Haque,

El-Nashar,

Akbor

et al. 2024

Front. Chem.

Self Cite

View full text Add to dashboard Cite

Introduction: D-pinitol, a naturally occurring inositol, has diverse biological activities like antioxidant, antimicrobial and anticancer activities. This study aimed to evaluate anti-inflammatory effect of d-pinitol in a chick model. Additionally, in silico studies were performed to evaluate the molecular interactions with cyclooxygenase-2 (COX-2).Methods: The tested groups received d-pinitol (12.5, 25, and 50 mg/kg) and the standard drugs celecoxib and ketoprofen (42 mg/kg) via oral gavage prior to formalin injection. Then, the number of licks was counted for the first 10 min, and the paw edema diameter was measured at 60, 90, and 120 min.Results and Discussion: The d-pinitol groups significantly (p < 0.05) reduced the number of paw licks and paw edema diameters, compared to negative control. When d-pinitol was combined with celecoxib, it reduced inflammatory parameters more effectively than the individual groups. The in silico study showed a promising binding capacity of d-pinitol with COX-2. Taken together, d-pinitol exerted anti-inflammatory effects in a dose-dependent manner, possibly through COX-2 interaction pathway.

show abstract

Sclareol exerts synergistic antidepressant effects with quercetin and caffeine, possibly suppressing GABAergic transmission in chicks

Kamli,

Shaikh,

Bappi

et al. 2023

Biomedicine & Pharmacotherapy

View full text Add to dashboard Cite

Anxiolytic-like effect of succinic acid: A possible GABAergic intervention

Cited by 5 publications

References 70 publications

Quercetin increases the antidepressant‐like effects of sclareol and antagonizes diazepam in thiopental sodium‐induced sleeping mice: A possible GABAergic transmission intervention

Quercetin increases the antidepressant‐like effects of sclareol and antagonizes diazepam in thiopental sodium‐induced sleeping mice: A possible GABAergic transmission intervention

Anti-inflammatory activity of d-pinitol possibly through inhibiting COX-2 enzyme: in vivo and in silico studies

Sclareol exerts synergistic antidepressant effects with quercetin and caffeine, possibly suppressing GABAergic transmission in chicks

Contact Info

Product

Resources

About