Anxiolytic-like activity of oxytocin in male mice: behavioral and autonomic evidence, therapeutic implications

Ring, Robert H.; Malberg, Jessica E.; Potestio, Lisa; Ping, Julia; Boikess, Steve; Luo, Bin; Schechter, Lee E.; Rizzo, Stacey J. Sukoff; Rahman, Zia Ur; Rosenzweig‐Lipson, Sharon

doi:10.1007/s00213-005-0293-z

Cited by 268 publications

(244 citation statements)

References 40 publications

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“…Further, for three peptides that are considered to be anxiogenic, CRF, Ucn 1, and Ucn 3, each impairs aggression when injected centrally (D'Anna et al, 2005;Gammie et al, 2004). In addition, oxytocin has been found to both elevate maternal aggression (Bosch et al, 2005) and to decrease anxiety (Ring et al, 2006). Thus, for five modulators known to alter anxiety, in each case maternal aggression is inversely regulated relative to fear/anxiety.…”

Section: Discussionmentioning

confidence: 99%

GABA enhancement of maternal defense in mice: Possible neural correlates

Lee

Gammie

2007

Pharmacology Biochemistry and Behavior

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Previous studies have shown that low doses of GABA A receptor agonists facilitate maternal defense of offspring (maternal aggression), without significantly affecting other maternal behaviors. In addition, it has been demonstrated that endogenous changes in GABAergic neurotransmission occur in association with lactation. This study investigated the effects of GABA A receptor agonist, chlordiazepoxide (CDP), a benzodiazepine (BDZ), on maternal behaviors including aggression, and identified brain regions with altered activity in association with treatment. Another aim of the study was to determine whether CDP injections could prevent decreases in maternal aggression that occur with pup separation. Intraperitoneal injections of 1mg/kg of CDP significantly increased maternal defense without affecting other maternal behaviors, although a trend towards elevated nursing was noted. CDP significantly reduced c-Fos in lateral septum (LS) and caudal periaqueductal gray (cPAG) in behaviorally-experienced mice relative to vehicle-injected controls. In behaviorally-naïve subjects, CDP also decreased c-Fos in LS, but in cPAG this decrease was just above significance (p = 0.051). CDP was not sufficient to "rescue" maternal aggression when pup stimulus was removed. Overall, these studies provide further insights into the role for GABA in maternal behaviors, including aggression, and how and where BDZs may act to modulate behavior.

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Section: Discussionmentioning

confidence: 99%

GABA enhancement of maternal defense in mice: Possible neural correlates

Lee

Gammie

2007

Pharmacology Biochemistry and Behavior

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“…These populations have also been implicated in autonomic outflow through the stellate ganglion (27). In addition, both intracerebral CRH and OT modify autonomic activity (28,29). In the LH, ORX and MCH cell populations project to both liver and adipose tissue.…”

Section: Discussionmentioning

confidence: 99%

Identification of neuronal subpopulations that project from hypothalamus to both liver and adipose tissue polysynaptically

Stanley

Pinto

Segal

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

159

134

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The autonomic nervous system regulates fuel availability and energy storage in the liver, adipose tissue, and other organs; however, the molecular components of this neural circuit are poorly understood. We sought to identify neural populations that project from the CNS indirectly through multisynaptic pathways to liver and epididymal white fat in mice using pseudorabies virus strains expressing different reporters together with BAC transgenesis and immunohistochemistry. Neurons common to both circuits were identified in subpopulations of the paraventricular nucleus of the hypothalamus (PVH) by double labeling with markers expressed in viruses injected in both sites. The lateral hypothalamus and arcuate nucleus of the hypothalamus and brainstem regions (nucleus of the solitary tract and A5 region) also project to both tissues but are labeled at later times. Connections from these same sites to the PVH were evident after direct injection of virus into the PVH, suggesting that these regions lie upstream of the PVH in a common pathway to liver and adipose tissue (two metabolically active organs). These common populations of brainstem and hypothalamic neurons express neuropeptide Y and proopiomelanocortin in the arcuate nucleus, melanin-concentrating hormone, and orexin in the lateral hypothalamus and in the corticotrophin-releasing hormone and oxytocin in the PVH. The delineation of this circuitry will facilitate a functional analysis of the possible role of these potential commandlike neurons to modulate autonomic outflow and coordinate metabolic responses in liver and adipose tissue.autonomic nervous system | neuronal tracing | pseudorabies virus T he autonomic nervous system plays a prominent role in modulating carbohydrate and lipid metabolism. The original theories of sympathetic activation (1) proposed a body-wide increase in sympathetic outflow. However, later studies suggested differential sympathetic activation on specific organs through distinct autonomic projections, which permits more finely tuned control of metabolism (2, 3).The liver and adipose tissue play important roles in fuel storage and release. These organs respond to altered energy availability with a set of homeostatic responses mediated by humoral factors and autonomic outflow. For example, activation of hepatic sympathetic aminergic and peptidergic innervation increases glucose output and modulates fatty acid transport. Conversely, parasympathetic activity decreases hepatic glucose output and increases carbohydrate storage (4). Likewise, the sympathetic innervation of white adipose tissue induces lipolysis (5) and alters glucose uptake. Thus, in general, parasympathetic activity favors fuel storage, whereas sympathetic activity increases the fuel available for immediate use.Many CNS regions regulate autonomic outflow to hepatic or adipose tissue to influence peripheral energy homeostasis. In particular, the ventromedial hypothalamus (VMH), dorsomedial hypothalamus (DMH), lateral hypothalamus (LH), and nucleus of the solitary tract (NTS) (6)...

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“…Benzodiazepine wirken postsynaptisch am GABA-Rezeptor als GABA-A-Agonisten, während Oxytocin präsynaptisch über verstärkte GABA-Ausschüttung wirkt [37]. In unterschiedlichen Tests war der anxiolytische Effekt von Oxytocin mit dem eines Benzodiazepins vergleichbar [47]. Oxytocin bewirkt ebenso wie ein Benzodiazepin Anxiolyse, nach 10 Tagen trat jedoch bei Diazepam in einer Tierstudie ein Gewöhnungseffekt ein, der bei Oxytocin nicht zu verzeichnen war [48].…”

Section: Oxytocin Im Einsatz Gegen Suchtmechanismenunclassified

Oxytocin und die suchterhaltenden Mechanismen der Alkoholabhängigkeit

2017

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Oxytocin and the mechanisms of alcohol dependenceSummary One of the crucial purposes of treating alcohol-dependent patients is to enhance their ability to stay abstinent after detoxification therapy. Anxiety and stress vulnerability are the main factors provoking alcohol craving and relapse. In the first months of abstinence, alcohol-dependent patients frequently show sleep disturbances, irritability and depression, indicating chronic activation of stress pathways. In addition, the loss of confidence in interpersonal interactions results in social withdrawal and reduced willingness to participate in therapeutic programs. Current research shows that the peptide hormone oxytocin exerts substantial anxiolytic effects and facilitates prosocial behavior. Oxytocin can be safely ap-K

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Anxiolytic-like activity of oxytocin in male mice: behavioral and autonomic evidence, therapeutic implications

Cited by 268 publications

References 40 publications

GABA enhancement of maternal defense in mice: Possible neural correlates

GABA enhancement of maternal defense in mice: Possible neural correlates

Identification of neuronal subpopulations that project from hypothalamus to both liver and adipose tissue polysynaptically

Oxytocin und die suchterhaltenden Mechanismen der Alkoholabhängigkeit

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