Anxiolytic effects of nicotine in zebrafish

Levin, Edward D.; Bencan, Zachary; Cerutti, Daniel T.

doi:10.1016/j.physbeh.2006.08.026

Cited by 534 publications

(452 citation statements)

References 23 publications

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“…Поведенческие эффекты у Danio rerio показаны так-же после применения этанола [13], никотина [17], морфина [7], фенамина [23], бензодиазепинов [3] и кокаина [19]. Влияние стресса новизны у Danio rerio можно тестировать и в ряде дополнительных тестов, таких как свет -темнота [21,23], Т-образный лабиринт [24], «открытое поле» [18]. Таким образом, можно более подробно проанализировать поведение животных.…”

Section: Abstract unclassified

“…Двигательное (и исследовательское) поведение значительно снижается по сравнению с поведени-ем в домашнем аквариуме [26,28]. После периода адаптации к просмотровому аквариуму поведение становится во многом подобно таковому в домаш-нем аквариуме, то есть двигательная активность увеличивается, уменьшается фризинг и увеличива-ется число переходов в верхнюю половину аквари-ума [17,18,24].…”

Section: обсуждение полученных результатовunclassified

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Effect of novelty stress on behavioral responses of Danio rerio and assessment of dose-dependent effects of anxiolytics of benzodiazepine structure with phenazepam as an example

Shabanov

Lebedev

Лебедев

et al. 2017

Rev Clin Pharm Drug Ther

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The effect of benzodiazepine anxiolytic phenazepam in Danio rerio was investigated. Previously, Danio rerio showed the effects of other anxiolytics, dia_zepam and chlordiazepoxide. The analysis of the anxiolytic effect of phenazepam in Danio rerio was carried out for the first time. Methods. A stress test on novelty situation was used: a fish was placed first in a beaker with a dissolved pharmacological substance (or water) and then into a novel tank for 6 min, where the trajectory, the path length, the number of movements to the upper part of the novel tank, the number and time of the pattern of “freezing” for each min of the experiment were measured. Results. In response to the novelty of tank, the fish was shown to react by submerging to the bottom, increasing the freezing, and reducing the number of movements to the upper half of the novel tank. After phenazepam exposure (administration), the fish was not only in the lower, but also in the upper part of the novel tank. The average path length did not change significantly in the range of the doses used. The number and time of the freezing, as well as the time spent in the lower part of the novel tank, 2-fold decreased compared to the control group of animals and showed a dose-dependent effect. The number of movements to the upper part of the novel tank for the experiment increased significantly from 1 in the control to 57 after phenazepam in a dose of 1 mg/l. When analyzing the dynamics of the parameters for each min, it was shown that the time of the fish in the lower part of the novel tank decreased from 3th min of the experiment with the use of phenazepam in a dose of 0.5 mg/l. At the same time, the number of movements of fish to the upper part of the novel tank significantly increased more than 2 times from 3th min of the experiment with the use of phenazepam in a dose of 1 mg/l. Conclusion. The described method to study behavioral responses of Danio rerio on novelty stress is high sensitive in comparison with traditional behavioral methods of studing tranquilizers. The prospect of using Danio rerio as animal model in behavioral pharmacology is significant and does not concede research on rodents.

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Section: Abstract unclassified

Section: обсуждение полученных результатовunclassified

Effect of novelty stress on behavioral responses of Danio rerio and assessment of dose-dependent effects of anxiolytics of benzodiazepine structure with phenazepam as an example

Shabanov

Lebedev

Лебедев

et al. 2017

Rev Clin Pharm Drug Ther

View full text Add to dashboard Cite

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“…Egan et al (2009) also reported similar findings. Levin et al (2007) showed nicotine had anxiolytic properties as this drug reduced novelty induced fear responses. In addition to novelty, different levels of illumination have also been explored to induce and test fear responses.…”

Section: Automation Is the Key For High Throughput Screeningmentioning

confidence: 99%

“…Importantly, behavioural experimentation always includes at least some level of handling of animals by humans, which is also expected to induce fear. Novelty induced fear responses have been analyzed in zebrafish by Levin et al (2007) who showed an initially low level of exploratory activity of zebrafish that gradually increased with time. These authors also described a "diving" response, i.e.…”

Section: Automation Is the Key For High Throughput Screeningmentioning

confidence: 99%

Zebrafish, a Potential Novel Research Tool for the Analysis and Modeling of Anxiety

Gerlai

2011

Different Views of Anxiety Disorders

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“…A novel tank diving test was conducted employing the methodology by Levin et al (23). All the behavioral tests were video-recorded by iPhone.…”

Section: Behavioral Analysismentioning

confidence: 99%

Deficits in Striatal Dopamine and Hippocampal Serotonin Following Induction of Anxiety/Depressive-Like Behaviors by Bisphenol A

Jia

Pittman

2014

Arch Neurosci

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Background: Anxiety and depression are common nonmotor symptoms of Parkinson's disease (PD). Objectives: We investigated whether Bisphenol A (BPA) is capable of inducing anxiety/depressive-like behaviors and neurotransmitter alterations that are similar to those observed in PD. Materials and Methods:To test this hypothesis, we used a zebrafish animal model and conducted behavioral and histological assays. Results: BPA produced anxiety/depression-like behavioral signs for 14 days following administration. Altered behavioral responses were accompanied by reductions of striatal dopamine transporter, and decrease in hippocampal 5-HT content. Conclusions: These results suggest that the nigrostriatal pathway might play a role in the etiology of anxiety/depression. Furthermore, dopamine transporter function, in particular, might play a critical role in the pathophysiology of anxiety/depression.

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Anxiolytic effects of nicotine in zebrafish

Cited by 534 publications

References 23 publications

Effect of novelty stress on behavioral responses of Danio rerio and assessment of dose-dependent effects of anxiolytics of benzodiazepine structure with phenazepam as an example

Effect of novelty stress on behavioral responses of Danio rerio and assessment of dose-dependent effects of anxiolytics of benzodiazepine structure with phenazepam as an example

Zebrafish, a Potential Novel Research Tool for the Analysis and Modeling of Anxiety

Deficits in Striatal Dopamine and Hippocampal Serotonin Following Induction of Anxiety/Depressive-Like Behaviors by Bisphenol A

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