Anxiolytic effect of Kami-Shoyo-San (TJ-24) in mice Possible mediation of neurosteroid synthesis

Mizowaki, Maho; Toriizuka, Kazuo; Hanawa, Toshihiko

doi:10.1016/s0024-3205(01)01290-5

Cited by 45 publications

(26 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, this formula is effective for treating affective disorders (Zhang et al, 1994), indicating the central activity of KSS. Previously, the anxiolytic effect of KSS was revealed using a SI test on mice (Mizowaki et al, 2001). Oral administration of KSS increased the total SI time and the effect was as strong as for diazepam, suggesting that acute administration of KSS is as effective as general anxiolytics.…”

Section: Discussionmentioning

confidence: 96%

“…Kamishoyosan (Jia-wei-xiao-yao-san in Chinese) is one formula used to treat anxiety, irritability and depression in menopausal women (Furuya and Toriizuka, 1996). Previously, the anxiolytic effect of KSS was revealed using a social interaction (SI) test in mice, and it was also reported that the mechanism responsible for these anxiolytic effect was mediated by GABA A /BDZ receptor stimulation involved in the neurosteroids synthesis (Mizowaki et al, 2001). The SI test for this model reflects bneural anxietyQ, because it does not involve food or water deprivation or electric shock (File, 1980).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Anxiolytic effect of Gardeniae Fructus-extract containing active ingredient from Kamishoyosan (KSS), a Japanese traditional Kampo medicine

et al. 2005

Self Cite

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Anxiolytic effect of Gardeniae Fructus-extract containing active ingredient from Kamishoyosan (KSS), a Japanese traditional Kampo medicine

et al. 2005

Self Cite

View full text Add to dashboard Cite

“…33) Moreover, the mechanism may be related to the mediation of neurosteroid synthesis, 34) the modulation of the locus coeruleus-norepinephrine system, 35) and the serum levels of 5-HT, brain derived neurotrophic factor (BDNF), CORT and interleukin-6.…”

Section: )mentioning

confidence: 99%

Xiao Yao San Improves the Anxiety-Like Behaviors of Rats Induced by Chronic Immobilization Stress: The Involvement of the JNK Signaling Pathway in the Hippocampus

Zhao

Jiang

et al. 2017

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

The current study evaluated the effects of Xiao Yao San (XYS) on anxiety-like behaviors and sought to determine whether the c-Jun N-terminal kinase (JNK) signaling pathway is involved. A total of 40 rats were divided into 5 groups (n 8): the control group (deionized water, per os ( p.o.)), the model group (deionized water, p.o.), the SP600125 group (surgery), the per se group (surgery), and the XYS group (3.9 g/kg/d, p.o.). A 1% dimethyl sulfoxide (DMSO) citrate buffer solution (2 µL/ventricle/d) and SP600125 (10 µg/ventricle, 2 µL/ventricle/d) were separately and bilaterally injected into the rats of the two surgery groups via the ventricular system of the brain. All but the control group underwent 14 d of chronic immobilization stress (CIS; 3 h/d). On day 15, the body weights of all of the rats were measured; additionally, the rats were subjected to the elevated plus maze (EPM) and novelty suppressed feeding (NSF) tests. Finally, JNK signaling pathway indices, including phosphorylated JNK (P-JNK), JNK, phosphorylated c-Jun (P-c-Jun) and cytochrome C (Cyt-C), were examined. After modeling, the body weight and behavioral analyses of the model rats indicated that this modeling method induced anxiety-like behaviors. P-JNK, JNK, and P-c-Jun were altered in the hippocampus of the model rats. After 14 d of treatment with XYS and SP600125, rat body weight and behaviors as well as P-JNK, JNK, and P-c-Jun had changed. However, no significant difference in Cyt-C was found. XYS improves the anxiety-like behaviors induced by CIS, which might be related to the JNK signaling pathway in the hippocampus.

show abstract

“…It may also be impossible to attribute all the beneficial effects of the KSS/TSS therapy to the increased serum level of E 2 . KSS has been known to possess anxiolytic effects in rats, an effect said to be mediated by the stimulation of the brain Á-aminobutyric acid A /benzodiazepine receptor [13]. Besides, TSS had an analgesic effect in women with dysmenorrhea [14] and antioxidant actions in the central nervous system [15], although to what extent these findings are related to climacteric symptoms is not known.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Climacteric Symptoms with Herbal Formulas of Traditional Chinese Medicine

Pan

Kato²,

Sengoku³

et al. 2004

Gynecol Obstet Invest

View full text Add to dashboard Cite

Hormone replacement therapy (HRT) is not successful or is contraindicated for the treatment of climacteric symptoms in some patients. To investigate whether certain herbal formulas of traditional Chinese medicine (Kampo in Japanese) could be used as an alternative treatment, a longitudinal ‘before and after’ comparative study was carried out in 18 Japanese women, and the results were compared with those of 16 women who underwent HRT. Kampo improved all the climacteric symptoms. In contrast, improvement of cold limbs, sleeping disorders, shoulder stiffness/lumbago, and fatigue in the HRT group was either not significant or of limited extent. In addition, the serum level of estradiol in postmenopausal women was raised by the combined use of two Kampo formulas. These results suggest that Kampo may be considered an alternative to HRT for the treatment of climacteric symptoms, but vigorous monitoring for potential side effects of increased estrogen levels in some postmenopausal patients is needed.

show abstract

Anxiolytic effect of Kami-Shoyo-San (TJ-24) in mice Possible mediation of neurosteroid synthesis

Cited by 45 publications

References 0 publications

Anxiolytic effect of Gardeniae Fructus-extract containing active ingredient from Kamishoyosan (KSS), a Japanese traditional Kampo medicine

Anxiolytic effect of Gardeniae Fructus-extract containing active ingredient from Kamishoyosan (KSS), a Japanese traditional Kampo medicine

Xiao Yao San Improves the Anxiety-Like Behaviors of Rats Induced by Chronic Immobilization Stress: The Involvement of the JNK Signaling Pathway in the Hippocampus

Treatment of Climacteric Symptoms with Herbal Formulas of Traditional Chinese Medicine

Contact Info

Product

Resources

About