Anxiolytic Effect of Increased NREM Sleep after Acute Social Defeat Stress in Mice

Xiao, Feng; Zhao, Huiying; Shao, Yu-Jin; Lou, Huifang; Zhu, Liya; Duan, Shumin; Yu, Yan-Qin

doi:10.1007/s12264-020-00473-y

Cited by 22 publications

(11 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The criteria used to categorize the susceptible and the resilient phenotypes vary between labs which is another potential cause for differences in findings between the various studies ( Henderson et al, 2017 ; Wells et al, 2017 ). Furthermore, several of the studies assessed the effect of acute, not chronic, social defeat stress on sleep ( Wells et al, 2017 ; Fujii et al, 2019 ; Feng et al, 2020 ) and many focused on REM sleep abnormalities in association with the depressive-like phenotype, despite observations that the diagnostic value of REM sleep abnormalities as a marker of depression has been shown to be confounded with age and gender effects ( Thase et al, 1998 ). In our study we also observed REM sleep abnormalities in terms of higher number of REM sleep bouts in the dark, pre-CSD, in mice that become susceptible to stress ( p = 0.056) and augmented REM sleep rebound, following SD, in the susceptible mice, post-CSD.…”

Section: Discussionmentioning

confidence: 99%

Abnormal Sleep Signals Vulnerability to Chronic Social Defeat Stress

2021

View full text Add to dashboard Cite

There is a tight association between mood and sleep as disrupted sleep is a core feature of many mood disorders. The paucity in available animal models for investigating the role of sleep in the etiopathogenesis of depression-like behaviors led us to investigate whether prior sleep disturbances can predict susceptibility to future stress. Hence, we assessed sleep before and after chronic social defeat (CSD) stress. The social behavior of the mice post stress was classified in two main phenotypes: mice susceptible to stress that displayed social avoidance and mice resilient to stress. Pre-CSD, mice susceptible to stress displayed increased fragmentation of Non-Rapid Eye Movement (NREM) sleep, due to increased switching between NREM and wake and shorter average duration of NREM bouts, relative to mice resilient to stress. Logistic regression analysis showed that the pre-CSD sleep features from both phenotypes were separable enough to allow prediction of susceptibility to stress with >80% accuracy. Post-CSD, susceptible mice maintained high NREM fragmentation while resilient mice exhibited high NREM fragmentation, only in the dark. Our findings emphasize the putative role of fragmented NREM sleep in signaling vulnerability to stress.

show abstract

Section: Discussionmentioning

confidence: 99%

Abnormal Sleep Signals Vulnerability to Chronic Social Defeat Stress

2021

View full text Add to dashboard Cite

show abstract

“…Although the function and benefits of sleep remain unclear, sleep is certainly restorative ( 10 ). Thus, sleep has been suggested to be one of the mechanisms for alleviating the malign effects of stress ( 4 , 9 , 11 , 12 ). Whether a specific circuit links stress and sleep is, however, unknown.…”

mentioning

confidence: 99%

A specific circuit in the midbrain detects stress and induces restorative sleep

Zhao

Wang

et al. 2022

Science

View full text Add to dashboard Cite

In mice, social defeat stress (SDS), an ethological model for psychosocial stress, induces sleep. Such sleep could enable resilience, but how stress promotes sleep is unclear. Activity-dependent tagging revealed a subset of ventral tegmental area γ-aminobutyric acid (GABA)–somatostatin (VTA Vgat-Sst ) cells that sense stress and drive non–rapid eye movement (NREM) and REM sleep through the lateral hypothalamus and also inhibit corticotropin-releasing factor (CRF) release in the paraventricular hypothalamus. Transient stress enhances the activity of VTA Vgat-Sst cells for several hours, allowing them to exert their sleep effects persistently. Lesioning of VTA Vgat-Sst cells abolished SDS-induced sleep; without it, anxiety and corticosterone concentrations remained increased after stress. Thus, a specific circuit allows animals to restore mental and body functions by sleeping, potentially providing a refined route for treating anxiety disorders.

show abstract

“…Sleep architecture is significantly altered in sleep disorders, mood disorders, and infectious diseases ( Besedovsky et al, 2019 ; Irwin, 2019 ; Atrooz and Salim, 2020 ). Epidemiological studies have shown that sleep deficiency is associated with inflammation, neuropsychiatric diseases, and multi-organ injury ( Leproult et al, 2014 ; Irwin et al, 2016 ; Atrooz and Salim, 2020 ; Feng et al, 2020 ; Ramos-Lopez et al, 2021 ; Zhang et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Lonicerae Japonicae Flos Extract Promotes Sleep in Sleep-Deprived and Lipopolysaccharide-Challenged Mice

et al. 2022

View full text Add to dashboard Cite

Lonicerae Japonicae Flos (LJF) is commonly used in Chinese herbal medicines and exhibits anti-viral, anti-oxidative, and anti-inflammatory properties. The reciprocal relationship between sleep, the immune system and the central nervous system is well-established in the animal models. In this study, we used the mouse model to analyze the beneficial effects of the LJF on the dysregulated sleep-wakefulness cycle in response to acute sleep deprivation and lipopolysaccharide (LPS)-induced inflammation and the potential underlying mechanisms. Polysomnography data showed that LJF increased the time spent in non-rapid eye movement (NREM) sleep during the day under basal conditions. Furthermore, latency to sleep was reduced and the time spent in rapid eye movement (REM) sleep was increased during recovery from acute sleep deprivation. Furthermore, LJF-treated mice showed increased REM sleep and altered electroencephalogram (EEG) power spectrum in response to intra-peritoneal injection of LPS. LJF significantly reduced the levels of proinflammatory cytokines such as IL-6, TNF-α, and IL-1β in the blood serum as well as hippocampus, and medial prefrontal cortex (mPFC) tissues in the LPS-challenged mice by inhibiting microglial activation. Moreover, LJF increased the time spent in REM sleep in the LPS-challenged mice compared to the control mice. These results suggested that LJF stimulated the sleep drive in response to acute sleep deprivation and LPS-induced inflammation, thereby increasing REM sleep for recovery and neuroprotection. In conclusion, our findings demonstrate that the clinical potential of LJF in treating sleep disorders related to sleep deprivation and neuro-inflammation.

show abstract

Anxiolytic Effect of Increased NREM Sleep after Acute Social Defeat Stress in Mice

Cited by 22 publications

References 40 publications

Abnormal Sleep Signals Vulnerability to Chronic Social Defeat Stress

Abnormal Sleep Signals Vulnerability to Chronic Social Defeat Stress

A specific circuit in the midbrain detects stress and induces restorative sleep

Lonicerae Japonicae Flos Extract Promotes Sleep in Sleep-Deprived and Lipopolysaccharide-Challenged Mice

Contact Info

Product

Resources

About