Anxiolytic and antidepressant mechanisms of 5-HT1A drugs in the pigeon: Contributions from behavioral studies

Barrett, James E.; Zhang, L.; Gleeson, Suzanne; Gamble, Eleanore H.

doi:10.1016/0149-7634(94)90038-8

Cited by 20 publications

(4 citation statements)

References 57 publications

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“…On the other hand, the increased aggression could be the result of a direct action where the drug facilitates aggressive behaviour in otherwise nonaggressive birds. Acute doses of 8‐OH‐DPAT have been shown to be anxiolytic in both pigeons (40) and in rats (41). Although, depending upon whether pre or postsynaptic 5‐HT 1A receptors are activated, in rats, 8‐OH‐DPAT can act as an anxiolytic or an anxiogenic agent, respectively (41).…”

Section: Discussionmentioning

confidence: 99%

Effects of Acute Treatment with 8‐OH‐DPAT and Fluoxetine on Aggressive Behaviour in Male Song Sparrows (Melospiza melodia morphna)

Sperry

Thompson

Wingfield

2003

J Neuroendocrinology

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The role of serotonin in modulating male aggressive behaviour was investigated in male song sparrows, Melospiza melodia morphna, using two different serotonergic drugs, fluoxetine and 8-OH-DPAT. Fluoxetine is a selective serotonin reuptake inhibitor of the neuronal reuptake pump increasing synaptic concentrations of serotonin, and 8-OH-DPAT is a specific serotonin (5-HT1A) receptor agonist. The serotonergic control of aggression in passerines has not been previously investigated. We examined these behaviours within a controlled setting using a laboratory simulated territorial intrusion, with a hierarchical scale to quantify male-male aggressive behaviour. Utilizing this scale, we quantified the extent of male aggressive behaviour in two experiments. In experiment 1, song sparrows were given 100 micro l, s.c. injections of either fluoxetine (10 mg/kg) or 8-OH-DPAT (1 mg/kg). Experiment 2 was a dose-response study using three doses of 8-OH-DPAT (0.1, 1 and 10 mg/kg). In both studies, aggressive behaviour was measured 1 h after injection for 10 min in response to the presence of a novel male decoy combined with playback of conspecific song. Both drugs significantly reduced male aggressive behaviour, and 8-OH-DPAT did so in a dose-dependent manner. The effect of the two drugs upon general activity was also measured using infra-red perch hop detectors. Activity levels were not effected by either fluoxetine or 8-OH-DPAT at all of the respective doses, indicating that the reduction in aggressive behaviour was specific. These results demonstrate that, in a passerine species, the serotonergic system negatively regulates male-male aggressive behaviour. These results further demonstrate that aggression can be effectively studied in a laboratory setting and natural aggressive responses can be elicited using this method.

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Section: Discussionmentioning

confidence: 99%

Effects of Acute Treatment with 8‐OH‐DPAT and Fluoxetine on Aggressive Behaviour in Male Song Sparrows (Melospiza melodia morphna)

Sperry

Thompson

Wingfield

2003

J Neuroendocrinology

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“…A variety of serotoninergic drugs have been used in the treatment of anxiety and depression in humans, but have little or no effects in established animal models of either disorders with nonhuman mammals. Yet, pigeons respond to these drugs much like human patients (Barrett et al., 1994). One example is buspirone (a serotonin-1A-receptor agonist with anxiolytic effects).…”

Section: Avian Fearmentioning

confidence: 99%

Avian Emotions: Comparative Perspectives on Fear and Frustration

2019

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Emotions are complex reactions that allow individuals to cope with significant positive and negative events. Research on emotion was pioneered by Darwin’s work on emotional expressions in humans and animals. But Darwin was concerned mainly with facial and bodily expressions of significance for humans, citing mainly examples from mammals (e.g., apes, dogs, and cats). In birds, emotional expressions are less evident for a human observer, so a different approach is needed. Understanding avian emotions will provide key evolutionary information on the evolution of related behaviors and brain circuitry. Birds and mammals are thought to have evolved from different groups of Mesozoic reptiles, theropod dinosaurs and therapsids, respectively, and therefore, their common ancestor is likely to be a basal reptile living about 300 million years ago, during the Carboniferous or Permian period. Yet, birds and mammals exhibit extensive convergence in terms of relative brain size, high levels of activity, sleep/wakefulness cycles, endothermy, and social behavior, among others. This article focuses on two basic emotions with negative valence: fear and frustration. Fear is related to the anticipation of dangerous or threatening stimuli (e.g., predators or aggressive conspecifics). Frustration is related to unexpected reward omissions or devaluations (e.g., loss of food or sexual resources). These results have implications for an understanding of the conditions that promote fear and frustration and for the evolution of supporting brain circuitry.

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“…Pigeons (C. livia) is a key avian species in comparative neuroanatomical studies and the abundant hodological and neurochemical literature on this species is central to a number of important theories on brain evolution (see, for examples, Reiner, 2002;Reiner et al, 2004Reiner et al, , 2005. Pigeons have also been a common and relevant laboratory species in experimental psychology and behavioral pharmacology studies (e.g., McMillan, 1990), and most of our present knowledge on the important functions of the serotonergic circuitry on avian ingestive (Steffens et al, 1997;Da Silva et al, 2004Hä ckl et al, 2005 and defensive behaviors (e.g., Barrett et al, 1994) were obtained in this species. In the present study, we describe the distribution of TPH-immunoreactive somata and fibers, and its possible co-localization with 5-HT in the brainstem and hypothalamus of the pigeon.…”

mentioning

confidence: 98%

Distribution of tryptophan hydroxylase-immunoreactive neurons in the brainstem and diencephalon of the pigeon (Columba livia)

Meneghelli

Rocha

Mengatto

et al. 2009

Journal of Chemical Neuroanatomy

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Anxiolytic and antidepressant mechanisms of 5-HT1A drugs in the pigeon: Contributions from behavioral studies

Cited by 20 publications

References 57 publications

Effects of Acute Treatment with 8‐OH‐DPAT and Fluoxetine on Aggressive Behaviour in Male Song Sparrows (Melospiza melodia morphna)

Effects of Acute Treatment with 8‐OH‐DPAT and Fluoxetine on Aggressive Behaviour in Male Song Sparrows (Melospiza melodia morphna)

Avian Emotions: Comparative Perspectives on Fear and Frustration

Distribution of tryptophan hydroxylase-immunoreactive neurons in the brainstem and diencephalon of the pigeon (Columba livia)

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