Anxiolytic and antidepressant effects of ACPA and harmaline co-treatment

Ebrahimi-Ghiri, Mohaddeseh; Nasehi, Mohammad; Zarrindast, Mohammad‐Reza

doi:10.1016/j.bbr.2019.02.034

Cited by 23 publications

(17 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The number of entries in the arms was measured by two observers 41 . The number of entries in the enclosed arms and the total number of entries evaluate locomotor activity 42–45 .…”

Section: Methodsmentioning

confidence: 99%

High-fat diet intake induces depressive-like behavior in ovariectomized rats

Boldarine

Pedroso

Neto

et al. 2019

Sci Rep

View full text Add to dashboard Cite

This study tested the effects of ovariectomy, allied or not to high-fat feeding and estradiol replacement, on hormonal, metabolic and behavioral parameters, to explore the connection of obesity and depression after menopause. Wistar rats were either ovariectomized or sham-operated and fed with either standard chow or lard-enriched diet for twelve weeks. Sub-groups of ovariectomized rats received estradiol replacement. Depressive-like behaviors were assessed by the forced swim test and locomotor activity was assessed by the elevated plus maze test. Ovariectomy alone increased body weight gain and feed efficiency and induced hyperleptinemia and glucose intolerance while it increased caloric intake and body adiposity only marginally. High-fat intake alone induced obesity and, in combination with ovariectomy, accentuated the ovariectomy-induced alterations. Estradiol replacement attenuated the hormonal alterations only in chow-fed rats. Ovariectomy combined with high-fat intake induced depressive-like behaviors, which were marginally attenuated by estradiol. Depressive-like behaviors were associated with metabolic and body composition parameters and with estrogen status. The data indicate that the vulnerability to develop depression after menopause is influenced by high-fat intake. It is suggested that weight management is a crucial issue in postmenopausal women, probably having a beneficial role in preventing the appearance of mental health problems.

show abstract

“…The number of entries in the arms was measured by two observers 41 . The number of entries in the enclosed arms and the total number of entries evaluate locomotor activity 42–45 .…”

Section: Methodsmentioning

confidence: 99%

High-fat diet intake induces depressive-like behavior in ovariectomized rats

Boldarine

Pedroso

Neto

et al. 2019

Sci Rep

View full text Add to dashboard Cite

show abstract

“…The percentage of time spent in the OA [% time in OA = (time spent in the OA /time spent in all arms) × 100)] and the percentage of entries into the OA [% entries in OA = (OA entries/total entries in all arms) × 100] were measured to evaluate anxious-like behaviour. In addition, the total number of entries (into both enclosed and open arms) was used to evaluate spontaneous locomotor activity 61 .…”

Section: Analysis Of Anxious-like Behaviour: Epm Testmentioning

confidence: 99%

Ginkgo biloba extract (GbE) attenuates obesity and anxious/depressive-like behaviours induced by ovariectomy

Banin

Machado

Andrade

et al. 2021

Sci Rep

View full text Add to dashboard Cite

While several pieces of evidence link obesity and mood disorders in menopause, the mechanisms involved are not yet fully understood. We have previously demonstrated that Ginkgo biloba extract (GbE) both attenuated diet-induced obesity of male rats and restored serotonin-induced hypophagia in ovariectomized female rats. The present study aimed at exploring whether GbE treatment ameliorates ovariectomy-related obesity and anxious/depressive-like behaviours. Wistar female rats were either ovariectomized (OVX) or sham-operated (Sham). After 2 months, either 500 mg/kg of GbE or vehicle were administered daily by gavage for 14 days. Anxious/depressive-like behaviours were assessed by the Elevated Plus Maze and the Forced Swim Tests, respectively. Ovariectomy caused high visceral adiposity, hyperleptinemia, and hypercholesterolemia, and increased the anxiety index (p = 0.048 vs. Sham + GbE) while it decreased the latency to immobility (p = 0.004 vs. Sham). GbE treatment in OVX rats improved body composition, adiponectin levels and blood lipid profile. It also reduced the anxiety index (p = 0.004) and increased the latency to immobility (p = 0.003) of OVX rats. Linear regression analysis demonstrated that leptin (p = 0.047) and total cholesterol levels (p = 0.022) were associated with anxious-like behaviours while body adiposity (p = 0.00005) was strongly associated with depressive-like behaviours. The results showed that GbE therapy was effective in attenuating the deleterious effects of ovariectomy on body composition, lipid profile, and anxious/depressive-like behaviours. Further studies are warranted to better understand the therapeutic potential of GbE in menopause.

show abstract

“…Some scientific studies have reported volumetric modifications of parts of the brain in patients suffering from anxiety-depressive symptoms: conducted measurements through nuclear magnetic resonance (NMR) and positron emission tomography (PET) showed a reduction of the amygdala-hippocampus complexes and prefrontal cortexes of these patients as compared to the control group (Gupta et al, 2019). Following pharmacological therapy, the morphological and functional recovery of the aforementioned anatomical structures was found, and in animal models, the antidepressant therapy determined the multiplication of stem cells in the hippocampus and in the amygdala (Ebrahimi-Ghiri et al, 2019). Nevertheless, it is important to emphasize that pharmacological therapy does not completely solve anxiety-depressive symptoms (Akil et al, 2018).…”

Section: Classical Knowledge Of Anxiety-depression Asd and Ms: Braimentioning

confidence: 99%

The Contribution of Gut Microbiota–Brain Axis in the Development of Brain Disorders

et al. 2021

View full text Add to dashboard Cite

Different bacterial families colonize most mucosal tissues in the human organism such as the skin, mouth, vagina, respiratory, and gastrointestinal districts. In particular, the mammalian intestine hosts a microbial community of between 1,000 and 1,500 bacterial species, collectively called “microbiota.” Co-metabolism between the microbiota and the host system is generated and the symbiotic relationship is mutually beneficial. The balance that is achieved between the microbiota and the host organism is fundamental to the organization of the immune system. Scientific studies have highlighted a direct correlation between the intestinal microbiota and the brain, establishing the existence of the gut microbiota–brain axis. Based on this theory, the microbiota acts on the development, physiology, and cognitive functions of the brain, although the mechanisms involved have not yet been fully interpreted. Similarly, a close relationship between alteration of the intestinal microbiota and the onset of several neurological pathologies has been highlighted. This review aims to point out current knowledge as can be found in literature regarding the connection between intestinal dysbiosis and the onset of particular neurological pathologies such as anxiety and depression, autism spectrum disorder, and multiple sclerosis. These disorders have always been considered to be a consequence of neuronal alteration, but in this review, we hypothesize that these alterations may be non-neuronal in origin, and consider the idea that the composition of the microbiota could be directly involved. In this direction, the following two key points will be highlighted: (1) the direct cross-talk that comes about between neurons and gut microbiota, and (2) the degree of impact of the microbiota on the brain. Could we consider the microbiota a valuable target for reducing or modulating the incidence of certain neurological diseases?

show abstract

Anxiolytic and antidepressant effects of ACPA and harmaline co-treatment

Cited by 23 publications

References 41 publications

High-fat diet intake induces depressive-like behavior in ovariectomized rats

High-fat diet intake induces depressive-like behavior in ovariectomized rats

Ginkgo biloba extract (GbE) attenuates obesity and anxious/depressive-like behaviours induced by ovariectomy

The Contribution of Gut Microbiota–Brain Axis in the Development of Brain Disorders

Contact Info

Product

Resources

About