Anxiolytic and anti-colitis effects of Moringa oleifera leaf-aqueous extract on acetic acid-induced colon inflammation in rat

Noubissi, Paul Aimé; Njilifac, Queendoline; Tagne, Michel Archange Fokam; Nguepi, Mireille Sylviane Dongmo; Fondjo, Angèle Foyet; Emégam, Nadège Kouémou; Mukam, Joseph Ngakou; Zintchem, Roger; Wambe, Henri; Fankem, Gaétan Olivier; Tonfack, Agathe Fotio; Toukala, Jean Paul; Sotoing, Germain Taiwe; Kamgamg, René

doi:10.1016/j.biopha.2022.113652

Cited by 7 publications

(6 citation statements)

References 36 publications

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“…In acute UC, M. oleifera seed extract treatment was shown to reduce fecal lipocalin-2, downregulated gene expression of pro-inflammatory interleukin (IL)-1, IL-6, TNF-α, and inducible iNOS; upregulated claudin-1 and ZO-1 expression in acute and chronic colitis; as well as in chronic UC, upregulated GSTP1, which is an Nrf2 key mediator of phase II detoxifying enzyme [112]. Investigations by Noubissi et al 2022 using M. oleifera leaf-aqueous extract on acetic acid-induced acute UC corroborate these findings [3].…”

Section: Inflammatory Bowel Disease and M Oleiferamentioning

confidence: 89%

“…There is a dynamic relationship of mutual profits (symbiosis) established between the microbiota and human organism, which contributes to regular metabolic, immunological, and motor function maintenance, as well as to correct and adequate digestion and nutrient absorption [ 106 , 107 ]. The imbalance between the microbiota and gut defense system may result in aberrant inflammatory responses leading to neutrophil infiltration and chronic intestinal inflammation, as it is in the case of inflammatory bowel disease (IBD) [ 3 , 108 ]. IBD constitutes an immunological, histopathologically, and sometimes genetically heterogeneous group of bowel inflammation disorders, including Crohn’s disease (CD) and ulcerative colitis (UC) [ 3 , 108 ].…”

Section: Bioactive Components Of M Oleifera and Th...mentioning

confidence: 99%

“…The imbalance between the microbiota and gut defense system may result in aberrant inflammatory responses leading to neutrophil infiltration and chronic intestinal inflammation, as it is in the case of inflammatory bowel disease (IBD) [ 3 , 108 ]. IBD constitutes an immunological, histopathologically, and sometimes genetically heterogeneous group of bowel inflammation disorders, including Crohn’s disease (CD) and ulcerative colitis (UC) [ 3 , 108 ]. UC is a chronic illness at the origin of inflammation and/or ulceration of the large intestine’s (colon and rectum) epithelial lining, whereas Crohn’s disease can affect the layers of the alimentary tract and may even skip segments [ 109 ].…”

Section: Bioactive Components Of M Oleifera and Th...mentioning

confidence: 99%

“…Moringa stands as the sole genus in the Moringaceae family of flowering plants [ 2 , 3 ]. Among its various species, M. oleifera Lam ( Moringa pterygosperma G.) is the most popular and widespread and is native to Pakistan, India, Bangladesh, and Afghanistan.…”

Section: Introductionmentioning

confidence: 99%

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Bioactive Compounds in Moringa oleifera: Mechanisms of Action, Focus on Their Anti-Inflammatory Properties

Chiș,

Noubissi,

Pop

et al. 2023

Plants

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Moringa oleifera (M. oleifera) is a tropical tree native to Pakistan, India, Bangladesh, and Afghanistan; it is cultivated for its nutritious leaves, pods, and seeds. This scientific study was conducted to outline the anti-inflammatory properties and mechanisms of action of bioactive compounds from M. oleifera. The existing research has found that the plant is used in traditional medicine due to its bioactive compounds, including phytochemicals: flavonoids and polyphenols. The compounds are thought to exert their anti-inflammatory effects due to: (1) inhibition of pro-inflammatory enzymes: quercetin and kaempferol inhibit the pro-inflammatory enzymes (cyclooxygenase and lipoxygenase); (2) regulation of cytokine production: isothiocyanates modulate signaling pathways involved in inflammation, such as the nuclear factor-kappa B (NF-kappa B) pathway; isothiocyanates inhibit the production of pro-inflammatory cytokines such as TNF-α (tumor necrosis factor α) and IL-1β (interleukin-1β); and (3) antioxidant activity: M. oleifera contains flavonoids, polyphenols, known to reduce oxidative stress and inflammation. The review includes M. oleifera’s effects on cardiovascular protection, anti-hypertensive activities, type 2 diabetes, inflammatory bowel disease, and non-alcoholic fatty liver disease (NAFLD). This research could prove valuable for exploring the pharmacological potential of M. oleifera and contributing to the prospects of developing effective medicines for the benefit of human health.

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Section: Inflammatory Bowel Disease and M Oleiferamentioning

confidence: 89%

Section: Bioactive Components Of M Oleifera and Th...mentioning

confidence: 99%

Section: Bioactive Components Of M Oleifera and Th...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Bioactive Compounds in Moringa oleifera: Mechanisms of Action, Focus on Their Anti-Inflammatory Properties

Chiș,

Noubissi,

Pop

et al. 2023

Plants

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“…In the same prospect, alcoholic extract from MO has been approved to protect the stomach from ulcers induced by bisphenol via its antioxidant activities [32]. Leaves extracts have been approved to improve ulcerative colitis pathological consequences through their antioxidant power, and they elevated CAT and SOD and lowered MDA in rat's serum [299].…”

Section: Moringa Oleifera and Antioxidantsmentioning

confidence: 99%

Moringa oleifera: Recent Insights for Its Biochemical and Medicinal Applications

Abdelazim,

Afifi,

Abu-Alghayth

et al. 2024

Journal of Food Biochemistry

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Plants could be used for multiple medicinal purposes. Moringa oleifera (MO) is considered the most famous plant used for this purpose. The present review aimed to spot the light on the recent medicinal, biochemical, and nutritional applications of MO. The plant contains a huge number of nutrients such as fatty acids, amino acids, proteins, polysaccharides, minerals, and vitamins. It has been used to control glucose, lipids, proteins, minerals, vitamins, hormones, and antioxidants in many animals and human models. Its medicinal applications are also varied and wide; it could be used to control and manage lots of disorders. Extracts and isolated ingredients from the plant open the way for many researchers all over the world to study its biochemical and medicinal impact on many experimental and clinical models. The present review spots the light on the recent medicinal and biochemical significance of MO opening the discussion and demonstrating the strengths and weaknesses in the MO research area. Regardless of the contrary concept, we considered MO a promising plant that could be studied for its medicinal applications on both biochemical and molecular levels. We recommended further research on the molecular effects of MO in healthy and diseased models.

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Phytochemical analysis of Origanum majorana L. extract and investigation of its antioxidant, anti-inflammatory and immunomodulatory effects against experimentally induced colitis downregulating Th17 cells.

Taha

Elazab

Abdelbagi

et al. 2023

Journal of Ethnopharmacology

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Anxiolytic and anti-colitis effects of Moringa oleifera leaf-aqueous extract on acetic acid-induced colon inflammation in rat

Cited by 7 publications

References 36 publications

Bioactive Compounds in Moringa oleifera: Mechanisms of Action, Focus on Their Anti-Inflammatory Properties

Bioactive Compounds in Moringa oleifera: Mechanisms of Action, Focus on Their Anti-Inflammatory Properties

Moringa oleifera: Recent Insights for Its Biochemical and Medicinal Applications

Phytochemical analysis of Origanum majorana L. extract and investigation of its antioxidant, anti-inflammatory and immunomodulatory effects against experimentally induced colitis downregulating Th17 cells.

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