Anxiolytic activity of<i>Evolvulus alsinoides</i>and<i>Convulvulus pluricaulis</i>in rodents

Nahata, Alok; Patil, U. K.; Dixit, Vinod Kumar

doi:10.1080/13880200902822596

Cited by 51 publications

(33 citation statements)

References 19 publications

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“…Thus the antioxidant potential of the extracts may be the possible mode of the cytoprotective effects of the extracts and usage in stress induced disorders (Nahata et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…The defatted marc was subjected to ethanol extraction (2500 mL). Extraction was done according to the method followed in our previous studies (Nahata et al, 2009). The solvent free ethanol extract (yield: 12.23% w/w) was suspended in distilled water (200 mL) and fractionated with ethyl acetate (200 mL) to give the ethyl acetate soluble fraction and the aqueous fraction.…”

Section: Preparation Of Extractsmentioning

confidence: 99%

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Effect of Evolvulus alsinoides Linn. on learning behavior and memory enhancement activity in rodents

Nahata

Patil

Dixit

2009

Phytotherapy Research

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In the Ayurvedic system of medicine, the whole herb of 'Shankhpushpi' has been employed clinically for centuries for its memory potentiating, anxiolytic and tranquilizing properties. The present study was undertaken to investigate the effects of Evolvulus alsinoides (EA), considered as Shankhpushpi on learning and memory in rodents. Nootropic activity using Cook and Weidley's pole climbing apparatus, passive avoidance paradigms and active avoidance tests were used to test learning and memory. The ethanol extract of EA and its ethyl acetate and aqueous fractions were evaluated for their memory enhancing properties. Two doses (100 and 200 mg/kg p.o.) of the ethanol extract and ethyl acetate and aqueous fractions were administered in separate groups of animals. Both doses of all the extracts of EA significantly improved learning and memory in rats. Furthermore, these doses significantly reversed the amnesia induced by scopolamine (0.3 mg/kg i.p.). Nootropic activity was compared using piracetam as the standard. EA also exhibited potent memory enhancing effects in the step-down and shuttle-box avoidance paradigms.

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“…Thus the antioxidant potential of the extracts may be the possible mode of the cytoprotective effects of the extracts and usage in stress induced disorders (Nahata et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Section: Preparation Of Extractsmentioning

confidence: 99%

Effect of Evolvulus alsinoides Linn. on learning behavior and memory enhancement activity in rodents

Nahata

Patil

Dixit

2009

Phytotherapy Research

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“…No such response was observed with the aqueous fraction. Neuromuscular coordination and potent antioxidant potential was observed with the ethanolic extracts 20 .…”

Section: Anxiolytic Activitymentioning

confidence: 98%

A Review on Pharmacognosy and Pharmacology of Evolvulus Alsinoides (L.) L.

Sundaramurthi¹,

Kannan²

2017

Int. Res. J. Pharm.

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Plants are being used as therapeutic agents due to the side effects caused by synthetic drugs. Medicinal plants have been used from ancient time for the treatment and wellbeing of human beings. The metabolites of the plants are considered to be effective in treating many ailments. Various dosage forms and a wide array of extracts have been used in the traditional system of medicine with potent therapeutic activity experimentally and clinically. Evolvulus alsinoides (L). L is a perennial herb with anticonvulsant, nootropic, anti-inflammatory, antimicrobial, antioxidant, anxiolytic, cardioprotective effects and inhibition of lipid peroxidation in pancreas. This review article is a sincere effort to put forward the therapeutical importance and phytochemistry of the plant.

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“…It is a small perennial herb with small woody root stock and leaves alternate, simple, elliptic-oblong in shape. It has been reported as a brain tonic, antiulcer, anticatatonic (Purohit et al 1996), anxiolytic (Nahata et al 2009), conception aid, astringent, antidysenteric (Austin 2008), antioxidant (Cervenka et al 2008;Kumar et al 2010), antibacterial (Oliver 1983), antifungal agent (Aulakh et al 1998) and anti-stress drug (Gupta et al 2007). Also, the traditional memory enhancing effect of this plant has been evaluated and validated through evaluating adaptogenic and anti-amnesic properties (Siripurapu et al 2005;Nahata et al 2010).…”

Section: Introductionmentioning

confidence: 96%