Anxiolytic activity and active principles of Piper amalago (Piperaceae), a medicinal plant used by the Q’eqchi’ Maya to treat susto, a culture-bound illness

Mullally, Martha; Cayer, Christian; Muhammad, Aslam; Walshe-Roussel, Brendan; Ahmed, Fida; Sánchez-Vindas, Pablo; Rojas, Marco Otárola; Merali, Zul; Cal, Victor; Durst, Tony; Trudeau, Vance L.; Arnason, John T.

doi:10.1016/j.jep.2016.03.013

Cited by 17 publications

(7 citation statements)

References 21 publications

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“…The use of medicinal plants by the Q'eqchi' of Guatemala has been the subject of previous studies using different approaches, some of the most recent being studies on a specific species to treat the culture-bound illness “susto” (Mullally et al, 2016 ), the antifungal activity of a single species (Ta et al, 2016 ), the diagnosis of the single culture-bound illness “emplotment” (Hatala and Waldram, 2017 ), the investigation and review of Q'eqchi women's reproductive health in the Lake Izabal region (Michel et al, 2016 ), the broad study of Mayan phytomedicine in Guatemala and a further proposal for patient-centered boundary mechanisms to foster intercultural partnerships in health care (Hitziger et al, 2016 , 2017 ). The present study differs from these previous studies because it was conducted in three communities of Alta Verapaz with a normal population (no traditional healers).…”

Section: Introductionmentioning

confidence: 99%

Ethnopharmacological Field Study of Three Q'eqchi Communities in Guatemala

Vargas

Andrade‐Cetto

2018

Front. Pharmacol.

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Mesoamerica is well known for the Mayan civilization, which flourished in this region during pre-Columbian times and made use of plant diversity for medicinal purposes. Currently, there are 21 Mayan ethnic groups in Guatemala, including the Q'eqchi'. The use of medicinal plants is still prevalent among them, they have been an important medicinal source for the population. The present study aims to compile traditional knowledge of the use of medicinal plants from three Q'eqchi' communities in Alta Verapaz, Guatemala and identify the important medicinal plants that are currently being used to treat relevant diseases. The study also aims to determine the relative importance of the identified species to propose new species for further pharmacological studies. Based on the cultural richness and the low level of perturbation of the vegetation, we selected the Q'eqchi' communities of Sanimtaqá, Santo Domingo de las Cuevas, and Chirrepec in Alta Verapaz, Guatemala. There, semi-structured interviews were conducted between June 2013 and December 2014 with common people. Plant-related questions and certain sociocultural contexts of the informants were included. Herbarium specimens for identification were collected with the help of the informants in their gardens with people from each community. The data were analyzed in two forms, the first non-quantitative based on the interpretation of the interviews (emic concepts of diseases) the second by following quantitative methods: informant consensus factor (Fic), Friedman's fidelity index (Fl), and use-reports (Ur). A total of 169 interviews were conducted. One hundred thirty-seven species of plants with medicinal uses were identified, which were described 2,055 times. These species belong to 59 families and 117 genera. Gastrointestinal conditions and pain/fever had the highest number of plant species uses for treatment. The main gastrointestinal conditions included diarrhea (Nume'sa'), stomach pain and worms (Luqum), while the pain/fever classification included headaches (rail jolom), and fevers (Tiq'). The most important cultural condition is called Chaquiq'yaj, the symptoms of the disease; diarrhea, vomiting, fever, lack of appetite, and thirst could be associated with a gastrointestinal. Conclusions: After analyzing the data, we can conclude that; Ageratina ligustrina, Catopheria chiapensis, Baccharis inamoena, Peperomia maculosa, Baccharis salicina, Clinopodium brownei, Calea integrifolia, and Smallanthus maculatus var. maculatus are the most culturally relevant species.

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Section: Introductionmentioning

confidence: 99%

Ethnopharmacological Field Study of Three Q'eqchi Communities in Guatemala

Vargas

Andrade‐Cetto

2018

Front. Pharmacol.

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“…The different ways of healing the “ fright ” in the Bolivian plateau include the intake of medicinal plants 20 and “to call of the lost soul”, which is made through rituals of offerings (made by yampiris or yatiris ) or through the “white table”, performed by the kallawayas , who play other roles in the traditional Andean medicine 19 .…”

Section: Resultsmentioning

confidence: 99%

Culture-bound syndromes in migratory contexts: the case of Bolivian immigrants

Roldán-Chicano

Fernández-Rufete

Hueso‐Montoro

et al. 2017

Rev. Latino-Am. Enfermagem

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Objective:to describe the culture-bound syndromes maintained by Bolivian immigrants in the new migratory context and analyze the care processes of these health problems. Method:qualitative research with an ethnographic methodological approach. Sample: 27 Bolivian immigrants. In-depth interviews and participatory observation were the strategies used for data collection. Data were classified and categorized into logical schemes manually and using the ATLAS-ti program v.5. Results:susto, “wayras”, amartelo, pasmo de sol, pasmo de luna and pasmo de sereno are some of the folk illnesses that affect the Bolivian immigrants and that they have to treat in the new migratory context. Conclusions:in the new environment, the group under study preserves culture-bound syndromes that are common in their country of origin. The care strategies used for these health problems are adapted to the resources of the new context and based on interactions with the domestic environment, biomedicine and traditional medicine. It was observed the need for the health professionals to realize that the efficacy of certain therapies occurs within the scope of cultural beliefs and not in that of the scientific evidence.

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“…Analgesic: ethanolic leaf extract (100 mg/kg PO) and two isolated pyrrolidine amides (1 mg/kg PO) showed significant antinociceptive activity on mice in several pain models (da Silva Arrigo et al, 2016). Anxiolytic: ethanolic leaf extract 8-75 mg/kg PO) showed significant, dose-dependent anxiolytic-like effects in several rodent models (Mullally et al, 2016).…”

Section: Limited Evidence On Therapeutic Benefits and Safetymentioning

confidence: 99%

Traditional Herbal Medicine in Mesoamerica: Toward Its Evidence Base for Improving Universal Health Coverage

et al. 2020

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The quality of health care in Mesoamerica is influenced by its rich cultural diversity and characterized by social inequalities. Especially indigenous and rural communities confront diverse barriers to accessing formal health services, leading to often conflicting plurimedical systems. Fostering integrative medicine is a fundamental pillar for achieving universal health coverage (UHC) for marginalized populations. Recent developments toward health sovereignty in the region are concerned with assessing the role of traditional medicines, and particularly herbal medicines, to foster accessible and culturally pertinent healthcare provision models. In Mesoamerica, as in most regions of the world, a wealth of information on traditional and complementary medicine has been recorded. Yet these data are often scattered, making it difficult for policy makers to regulate and integrate traditionally used botanical products into primary health care. This critical review is based on a quantitative analysis of 28 survey papers focusing on the traditional use of botanical drugs in Mesoamerica used for the compilation of the "Mesoamerican Medicinal Plant Database" (MAMPDB), which includes a total of 12,537 use-records for 2188 plant taxa. Our approach presents a fundamental step toward UHC by presenting a pharmacological and toxicological review of the cross-culturally salient plant taxa and associated botanical drugs used in traditional medicine in Mesoamerica. Especially for native herbal drugs, data about safety and effectiveness are limited. Commonly used cross-culturally salient botanical drugs, which are considered safe but for which data on effectiveness is lacking constitute ideal candidates for treatment outcome studies.

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Anxiolytic activity and active principles of Piper amalago (Piperaceae), a medicinal plant used by the Q’eqchi’ Maya to treat susto, a culture-bound illness

Cited by 17 publications

References 21 publications

Ethnopharmacological Field Study of Three Q'eqchi Communities in Guatemala

Ethnopharmacological Field Study of Three Q'eqchi Communities in Guatemala

Culture-bound syndromes in migratory contexts: the case of Bolivian immigrants

Traditional Herbal Medicine in Mesoamerica: Toward Its Evidence Base for Improving Universal Health Coverage

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