Anxiety symptom interpretation: A potential mechanism explaining the cardiorespiratory fitness–anxiety relationship

Williams, Sarah E.; Carroll, Douglas; Zanten, Jet J.C.S. Veldhuijzen van; Ginty, Annie T.

doi:10.1016/j.jad.2015.12.051

Cited by 33 publications

(25 citation statements)

References 51 publications

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“…Our data suggest that the balance between β1-AR and β2-AR might be critical for the regulation sensitivity of anxiety-like behavior. However, it is also possible that β2-AR KO might influence the cardiovascular system, which also correlates with the anxiety level (Nabi et al, 2010; Roest et al, 2010; Balasubramaniyan et al, 2016; Williams et al, 2016). In this study, no difference in the exploration of central area in OF task was detected, not consistent with the results of reduced anxiety in L/D box and EPM test.…”

Section: Discussionmentioning

confidence: 99%

Lack of β2-AR Increases Anxiety-Like Behaviors and Rewarding Properties of Cocaine

Zhu

Liu

Zhou

et al. 2017

Front. Behav. Neurosci.

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It is well known that β-adrenoceptors (β-ARs) play a critical role in emotional arousal and stressful events, but the specific contributions of the β2-AR subtype to the psychological disorders are largely unknown. To investigate whether β2-AR are involved in anxiety-like behavior and reward to addictive drugs, we conducted a series of behavioral tests on β2-AR knock-out (KO) mice. β2-AR KO mice exhibited increased preference for the dark compartment and closed arm in tests of Light/Dark box and elevated plus maze, indicating that β2-AR deletion elevates level of anxiety or innate fear. β2-AR KO mice also showed decreased immobility in tail suspension test (TST), suggesting that β2-AR deletion inhibits depression-like behavior. Interestingly, β2-AR ablation did not change basal locomotion but significantly increased locomotor activity induced by acute cocaine administration. β2-AR KO mice showed enhanced place preference for cocaine, which could be attenuated by β1-selective AR antagonist betaxolol. Consistently, β2-AR agonist suppressed cocaine-conditioned place preference (CPP). These data indicate that β2-AR deletion enhances acute response and reward to cocaine. Our results suggest that β2-AR regulates anxiety level, depression-like behavior and hedonic properties of cocaine, implicating that β2-AR are the potential targets for the treatment of emotional disorders and cocaine addiction.

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Section: Discussionmentioning

confidence: 99%

Lack of β2-AR Increases Anxiety-Like Behaviors and Rewarding Properties of Cocaine

Zhu

Liu

Zhou

et al. 2017

Front. Behav. Neurosci.

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“…Prior to completing the questionnaire individuals are provided with definitions of each construct to ensure they fully understand the meaning of each one. The IAMS is a valid and reliable measure to assess state cognitive and somatic anxiety and self-confidence (Thomas et al, 2002) and has been used in previous imagery and stress research (e.g., Williams et al, 2010;Williams et al, 2016).…”

Section: Cognitive and Somatic Anxiety And Self-confidence The Immedmentioning

confidence: 99%

Challenge and threat imagery manipulates heart rate and anxiety responses to stress

Williams

Zanten

Trotman

et al. 2017

International Journal of Psychophysiology

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This study investigated the influence of different types of mental imagery on heart rate and anxiety responses to a standard psychological stress task. Using a within-design, 25 females (M=23.24; SD=4.19) imaged three different scripts (challenge, threat, and neutral) to manipulate appraisal of a speech preparation task. Following each script, participants completed the task. Heart rate was recorded during a resting baseline prior to each imagery script and during each speech preparation task. Cognitive and somatic anxiety and self-confidence were assessed prior to the speech preparation trials, and immediately prior to each speech preparation following imagery. Following threat imagery, participants reported the speech preparation task to be significantly more stressful and threatening, and experienced lower levels of confidence and more negative interpretations of their anxiety symptoms compared with the challenge and neutral imagery conditions. Additionally, there was a significantly greater increase in heart rate following threat imagery compared with challenge and neutral imagery. Findings demonstrate that imagery can alter stress appraisal and the accompanying cardiovascular and psychological responses to standardized stress tasks. Imagery interventions, acknowledging the stressful nature of events, but emphasising feelings of efficacy and control are likely to lead to more adaptive coping.

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“…In addition, physical fitness also serves as a buffer against stress and stress-related disorders ( 23 ). Anxiety is a stress-related mental health problem, but the association between physical fitness and anxiety is still unclear ( 24 , 25 ). Therefore, investigating the mechanisms underlying the role physical fitness plays in childhood anxiety is critically needed.…”

Section: Introductionmentioning

confidence: 99%

Association Between Physical Fitness and Anxiety in Children: A Moderated Mediation Model of Agility and Resilience

Xia

Meng

et al. 2020

Front. Public Health

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Background: Anxiety is one of the most prevalent mental health problems in children. Although physical fitness as a predictor of mental health, the mechanisms underlying any association between physical fitness and anxiety in children have been understudied. Thus, the aim of the present study was to determine whether an association exists between physical fitness and anxiety and to explore the roles of agility and resilience in such an association. Methods: This cross-sectional study investigated 269 children aged 7 to 12 years from three public primary schools in Shanghai (China). Physical fitness and agility were objectively measured, and resilience and anxiety were assessed using self-reported questionnaires. The moderated mediation model was examined using the SPSS PROCESS macro, in which the moderator variable was agility, and the mediator variable was resilience. Results: Physical fitness was inversely associated with anxiety. Resilience partially and indirectly mediated this association, and agility moderated the association between physical fitness and resilience. Physical fitness had a greater impact on resilience in children with higher agility levels. Conclusions: Agility moderated the mediation of resilience on the indirect, inverse association between physical fitness and anxiety; thus, incorporating methods to develop agility and resilience may lead to better outcomes for physical fitness programs designed to prevent or alleviate anxiety in children.

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Anxiety symptom interpretation: A potential mechanism explaining the cardiorespiratory fitness–anxiety relationship

Abstract: Results suggest a potential mechanism explaining how cardiorespiratory fitness can reduce anxiety levels.

Cited by 33 publications

References 51 publications

Lack of β2-AR Increases Anxiety-Like Behaviors and Rewarding Properties of Cocaine

Lack of β2-AR Increases Anxiety-Like Behaviors and Rewarding Properties of Cocaine

Challenge and threat imagery manipulates heart rate and anxiety responses to stress

Association Between Physical Fitness and Anxiety in Children: A Moderated Mediation Model of Agility and Resilience

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