Anxiety-related activity of ventral hippocampal interneurons

Forro, Thomas; Volitaki, Emmanouela; Malagon‐Vina, Hugo; Klausberger, Thomas; Nevian, Thomas; Ciocchi, Stéphane

doi:10.1016/j.pneurobio.2022.102368

Cited by 18 publications

(21 citation statements)

References 93 publications

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“…As the population of cortical neurons is composed of pyramidal cells and interneurons, we aimed to sort the recorded neurons according to their putative identity by examining the spike shape and the firing rate of the individual neurons (Csicsvari et al, 1998;Forro et al, 2022;Sirota et al, 2008). Due to the stability of the spike shapes during the time of the recording (Figure 3 Neuronal activity in the hippocampus is strongly affected by the emergence of sharp-wave ripples (SWR) (Buzsáki et al, 1992;Csicsvari et al, 1999;Ylinen et al, 1995).…”

Section: Overrepresentation and Remapping Of Vh Activity During Anxietymentioning

confidence: 99%

Firing Patterns of Ventral Hippocampal Neurons Predict the Exploration of Anxiogenic Locations

2022

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Section: Overrepresentation and Remapping Of Vh Activity During Anxietymentioning

confidence: 99%

Firing Patterns of Ventral Hippocampal Neurons Predict the Exploration of Anxiogenic Locations

2022

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“…As the population of cortical neurons is composed of pyramidal cells and interneurons, we aimed to sort the recorded neurons according to their putative identity by examining the spike shape and the firing rate of the individual neurons ( Csicsvari et al, 1998 ; Forro et al, 2022 ; Sirota et al, 2008 ). Due to the stability of the spike shapes during the time of the recording ( Figure 3—figure supplement 2A, B ), we divided the recorded neurons in putative pyramidal cells (n=80, 60.15%) and putative interneurons (n=24, 18.05%) by using a threshold for the though-to-peak latency and the firing rate (put.…”

Section: Resultsmentioning

confidence: 99%

“…In total six animals (SC61, SC63, SC65, SC66, SC67, SC68) were used for the EPM. Some data of these animals are also used in another independent publication ( Forro et al, 2022 ).…”

Section: Methodsmentioning

confidence: 99%

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Firing patterns of ventral hippocampal neurons predict the exploration of anxiogenic locations

Malagon‐Vina

Ciocchi

Klausberger

2023

eLife

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The ventral hippocampus (vH) plays a crucial role in anxiety-related behaviour and vH neurons increase their firing when animals explore anxiogenic environments. However, if and how such neuronal activity induces or restricts the exploration of an anxiogenic location remains unexplained. Here, we developed a novel behavioural paradigm to motivate rats to explore an anxiogenic area. Male rats ran along an elevated linear maze with protective sidewalls, which were subsequently removed in parts of the track to introduce an anxiogenic location. We recorded neuronal action potentials during task performance and found that vH neurons exhibited remapping of activity, overrepresenting anxiogenic locations. Direction-dependent firing was homogenised by the anxiogenic experience. We further showed that the activity of vH neurons predicted the extent of exploration of the anxiogenic location. Our data suggest that anxiety-related firing does not solely depend on the exploration of anxiogenic environments, but also on intentions to explore them.

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“…The spatial firing fields of neurons in the vHPC are typically broad 6,7 , effectively mapping entire contexts [8][9][10] . Additionally, vHPC neurons display selective firing patterns in situations that are associated with emotional valence and that elicit affect-driven behaviors, including behaviors associated with rewards [8][9][10][11][12] , and avoidance and defensive behaviours 4,8,[13][14][15] . Although there have been several studies that show how neuronal activity is related to reward-associated contexts in the ventral hippocampus (vHPC), the specific circuit mechanisms that are responsible for contextual memory of rewards remain poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Ventral hippocampal CCK interneurons gate context-reward memory

Nguyen

Sivakumaran

Lambe

et al. 2023

Preprint

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Associating contexts with rewards depends on hippocampal circuits, with local inhibitory interneurons positioned to play an important role in shaping activity. Here, we hypothesize that the encoding of context-reward memory requires a ventral hippocampus (vHPC) to nucleus accumbens (NAc) circuit that is gated by CCK interneurons. In a sucrose conditioned place preference (CPP) task, optogenetically inhibiting vHPC-NAc terminals impaired the acquisition of place preference. Transsynaptic rabies tracing revealed vHPC-NAc neurons were monosynaptically innervated by CCK interneurons. Using intersectional genetic targeting of CCK interneurons, ex vivo optogenetic activation of CCK interneurons increased GABAergic transmission onto vHPC-NAc neurons, while in vivo optogenetic inhibition of CCK interneurons increased cFos in these neurons. Notably, CCK interneuron inhibition during sucrose CPP learning increased time spent in the sucrose-associated location, suggesting enhanced place-reward memory. Our findings reveal a previously unknown hippocampal microcircuit crucial for modulating the strength of contextual reward learning.

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Anxiety-related activity of ventral hippocampal interneurons

Cited by 18 publications

References 93 publications

Firing Patterns of Ventral Hippocampal Neurons Predict the Exploration of Anxiogenic Locations

Firing Patterns of Ventral Hippocampal Neurons Predict the Exploration of Anxiogenic Locations

Firing patterns of ventral hippocampal neurons predict the exploration of anxiogenic locations

Ventral hippocampal CCK interneurons gate context-reward memory

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