Anxiety-like, novelty-seeking and memory/learning behavioral traits in male Wistar rats submitted to early weaning

Moura, Egberto Gaspar de; Lima, Natália da Silva; Lisboa, Patrícia Cristina; Oliveira, Elaine de; Silva, Juliana Oliveira; Claudio-Neto, S.; Filgueiras, Cláudio C.; Abreu‐Villaça, Yael; Manhães, Alex C.

doi:10.1016/j.physbeh.2013.11.001

Cited by 16 publications

(15 citation statements)

References 81 publications

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“…12 However, the precocious interruption of lactation can be a prime factor for behavioral changes, such as higher anxiety, higher motor activity and reduced cognitive performance, which exhibit significant sex dependence. [13][14][15] A limitation of the present study is the fact that we could not evaluate behavior and sex differences in relation to brain development. Even so, the lack of calories and fatty acids derived from milk was not offset by FF and FO experimental diets containing 25 g/100 g of flaxseed flour or 7 g/100 g of flaxseed oil, respectively.…”

Section: Discussionmentioning

confidence: 95%

Brain development in male rats subjected to early weaning and treated with diet containing flour or flaxseed oil after 21 days until 60 days

Pessanha

Boueri

Costa

et al. 2015

J Dev Orig Health Dis

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The precocious interruption of lactation is a prime factor for developmental plasticity. Here we analyzed whether flour or flaxseed oil treatment contributes to body and brain mass in male rats subjected to early weaning. Pups were weaned for separation from their mother at 14 (early weaning, EW) and 21 days (control, C). At 21 days, some of the pups were evaluated (C21 v. EW21). After 21 days, control pups (C60) were fed a control diet. EW pups were divided into those fed a control diet (EWC60), those given flaxseed flour (EWFF60), and those given flaxseed oil (EWFO60) until 60 days. EW21 showed lower body and absolute brain mass and higher relative brain mass. At 60 days, EWC60 and EWFO60 had lower body mass. With regard to relative brain mass, EWC60 was heavier; EWFO60 had lower values compared with EWC60 and higher values compared with C60 and EWFF60. These results indicated that flaxseed flour, in comparison with flaxseed oil, contributes to brain development after EW.

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Section: Discussionmentioning

confidence: 95%

Brain development in male rats subjected to early weaning and treated with diet containing flour or flaxseed oil after 21 days until 60 days

Pessanha

Boueri

Costa

et al. 2015

J Dev Orig Health Dis

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“…Indeed, we did not observe behavioral changes in adulthood. 104 Although they were not exposed to early-life stress, the NPEW offspring showed decreased body weight and length, adiposity, and serum glucose and serum insulin levels at PND21, which are changes related to milk deprivation. 102 At this age, the animals showed hypoleptinemia, hypothyroidism (low T3 syndrome), and unaltered adrenal catecholamine content.…”

Section: Nonpharmacological Early Weaningmentioning

confidence: 95%

Does early weaning shape future endocrine and metabolic disorders? Lessons from animal models

Souza

Moura

Lisboa

2020

J Dev Orig Health Dis

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Obesity and its complications occur at alarming rates worldwide. Epidemiological data have associated perinatal conditions, such as malnutrition, with the development of some disorders, such as obesity, dyslipidemia, diabetes, and cardiovascular diseases, in childhood and adulthood. Exclusive breastfeeding has been associated with protection against long-term chronic diseases. However, in humans, the interruption of breastfeeding before the recommended period of 6 months is a common practice and can increase the risk of several metabolic disturbances. Nutritional and environmental changes within a critical window of development, such as pregnancy and breastfeeding, can induce permanent changes in metabolism through epigenetic mechanisms, leading to diseases later in life via a phenomenon known as programming or developmental plasticity. However, little is known regarding the underlying mechanisms by which precocious weaning can result in adipose tissue dysfunction and endocrine profile alterations. Here, the authors give a comprehensive report of the different animal models of early weaning and programming that can result in the development of metabolic syndrome. In rats, for example, pharmacological and nonpharmacological early weaning models are associated with the development of overweight and visceral fat accumulation, leptin and insulin resistance, and neuroendocrine and hepatic changes in adult progeny. Sex-related differences seem to influence this phenotype. Therefore, precocious weaning seems to be obesogenic for offspring. A better understanding of this condition seems essential to reducing the risk for diseases. Additionally, this knowledge can generate new insights into therapeutic strategies for obesity management, improving health outcomes.

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“…10 pups of each group (except the N group which had 9 animals) from 10 litters were used. The EPM, which is shaped like a plus sign, is composed of two enclosed arms (CA, 50 cm long × 10 cm wide × 40 cm high) opposed perpendicularly by two open arms (OA, no walls, 50 cm long × 10 cm wide), and it is raised 50 [38][39][40][41]69]. The number of closed arm entries (Entries CA) was used as a measure of activity ( [40,41]).…”

Section: Behavioral Studiesmentioning

confidence: 99%

“…The EPM, which is shaped like a plus sign, is composed of two enclosed arms (CA, 50 cm long × 10 cm wide × 40 cm high) opposed perpendicularly by two open arms (OA, no walls, 50 cm long × 10 cm wide), and it is raised 50 [38][39][40][41]69]. The number of closed arm entries (Entries CA) was used as a measure of activity ( [40,41]). In addition, the percentage of time spent in the center of the maze (%Time CN: time spent in center divided by total time) was used as an independent measure of decision-making [38,69,93].…”

Section: Behavioral Studiesmentioning

confidence: 99%

Maternal nicotine exposure during lactation alters food preference, anxiety-like behavior and the brain dopaminergic reward system in the adult rat offspring

Pinheiro

Moura

Manhães

et al. 2015

Physiology & Behavior

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Anxiety-like, novelty-seeking and memory/learning behavioral traits in male Wistar rats submitted to early weaning

Cited by 16 publications

References 81 publications

Brain development in male rats subjected to early weaning and treated with diet containing flour or flaxseed oil after 21 days until 60 days

Brain development in male rats subjected to early weaning and treated with diet containing flour or flaxseed oil after 21 days until 60 days

Does early weaning shape future endocrine and metabolic disorders? Lessons from animal models

Maternal nicotine exposure during lactation alters food preference, anxiety-like behavior and the brain dopaminergic reward system in the adult rat offspring

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