Anxiety-like behavior and proinflammatory cytokine levels in the brain of C57BL/6 mice infected with Plasmodium berghei (strain ANKA)

Miranda, Aline Silva de; Lacerda-Queiroz, Norinne; Vilela, Márcia de Carvalho; Rodrigues, David Henrique; Quevedo, Joao L De

doi:10.1016/j.neulet.2011.01.038

Cited by 44 publications

(34 citation statements)

References 29 publications

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“…An increase in pro-inflammatory cytokines, particularly TNF-α, IL-1β and IL-6, has been reported for other cerebral infections (de Miranda et al, 2011;Gundra et al, 2011;Dvorak et al, 2004;Quan et al, 2003). Moreover, increased expression of inflammatory cytokines has been linked to anxiety-like behaviour (de Miranda et al, 2011), poor cognitive function (Lacerda-Queiroz et al, 2010), sleep impairment (Turrin and Plata-Salamán, 2000) and spatial recognition memory (Dinel et al, 2011).…”

Section: The Toxocara Mouse Model: Brain Involvement Accumulation Anmentioning

confidence: 96%

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The significance of cerebral toxocariasis: a model system for exploring the link between brain involvement, behaviour and the immune response

Holland

Hamilton

2013

Journal of Experimental Biology

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SummaryToxocara canis is a parasitic nematode that infects canines worldwide, and as a consequence of the widespread environmental dissemination of its ova in host faeces, other abnormal hosts including mice and humans are exposed to infection. In such abnormal or paratenic hosts, the immature third-stage larvae undergo a somatic migration through the organs of the body but fail to reach maturity as adult worms in the intestine. The presence of the migrating larvae contributes to pathology that is dependent upon the intensity of infection and the location of the larvae. A phenomenon of potential public health significance in humans and of ecological significance in mice is that T. canis larvae exhibit neurotrophic behaviour, which results in a greater concentration of parasites in the brain, as infection progresses. Toxocara larval burdens vary between individual outbred mice receiving the same inocula, suggesting a role for immunity in the establishment of cerebral infection. Although the systemic immune response to T. canis has been widely reported, the immune response in the brain has received little attention. Differential cytokine expression and other brain injury-associated biomarkers have been observed in infected versus uninfected outbred and inbred mice. Preliminary data have also suggested a possible link between significant memory impairment and cytokine production associated with T. canis infection. Mice provide a useful, replicable animal model with significant applicability and ease of manipulation. Understanding the cerebral host-parasite relationship may shed some light on the cryptic symptoms of human infection where patients often present with other CNS disorders such as epilepsy and mental retardation.

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Section: The Toxocara Mouse Model: Brain Involvement Accumulation Anmentioning

confidence: 96%

“…Moreover, increased expression of inflammatory cytokines has been linked to anxiety-like behaviour (de Miranda et al, 2011), poor cognitive function (Lacerda-Queiroz et al, 2010), sleep impairment (Turrin and Plata-Salamán, 2000) and spatial recognition memory (Dinel et al, 2011).…”

Section: The Toxocara Mouse Model: Brain Involvement Accumulation Anmentioning

confidence: 99%

The significance of cerebral toxocariasis: a model system for exploring the link between brain involvement, behaviour and the immune response

Holland

Hamilton

2013

Journal of Experimental Biology

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“…Under physiological conditions, IL-1β and TNF-α play an important role in neurogenesis, synaptic plasticity, long-term potentiation (LTP) and memory formation and consolidation 19,20 . On the other hand, the over-expression of these cytokines in the CNS has been associated with behavioral and cognitive impairment in several pathological conditions 21,22,23,24 .…”

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confidence: 99%

Memory deficit associated with increased brain proinflammatory cytokine levels and neurodegeneration in acute ischemic stroke

Silva

Sousa

Miranda

et al. 2015

Arq. Neuro-Psiquiatr.

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The present study aimed to investigate behavioral changes and neuroinflammatory process following left unilateral common carotid artery occlusion (UCCA O ), a model of cerebral ischemia. Post-ischemic behavioral changes following 15 min UCCA O were recorded 24 hours after reperfusion. The novel object recognition task was used to assess learning and memory. After behavioral test, brains from sham and ischemic mice were removed and processed to evaluate central nervous system pathology by TTC and H&E techniques as well as inflammatory mediators by ELISA. UCCA O promoted long-term memory impairment after reperfusion. Infarct areas were observed in the cerebrum by TTC stain. Moreover, the histopathological analysis revealed cerebral necrotic cavities surrounded by ischemic neurons and hippocampal neurodegeneration. In parallel with memory dysfunction, brain levels of TNF-a, IL-1b and CXCL1 were increased post ischemia compared with sham-operated group. These findings suggest an involvement of central nervous system inflammatory mediators and brain damage in cognitive impairment following unilateral acute ischemia.

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“…Evidence suggesting that TNF is another key element in the pathogenesis of experimental CM has been reviewed extensively (41,42). This includes the observation of high serum levels of TNF at the onset of CM (43) and the prevention of the neurological syndrome when TNF levels are low (44,45). Anti-inflammatory cytokines such as IL-10 seem to have a host-protective role in murine malaria.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Murine Cerebral Malaria by Artemisone in Combination with Conventional Antimalarial Drugs: Antiplasmodial Effects and Immune Responses

Guiguemde

Hunt

Guo

et al. 2014

Antimicrob Agents Chemother

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dThe decreasing effectiveness of antimalarial therapy due to drug resistance necessitates constant efforts to develop new drugs. Artemisinin derivatives are the most recent drugs that have been introduced and are considered the first line of treatment, but there are already indications of Plasmodium falciparum resistance to artemisinins. Consequently, drug combinations are recommended for prevention of the induction of resistance. The research here demonstrates the effects of novel combinations of the new artemisinin derivative, artemisone, a recently described 10-alkylamino artemisinin derivative with improved antimalarial activity and reduced neurotoxicity. We here investigate its ability to kill P. falciparum in a high-throughput in vitro assay and to protect mice against lethal cerebral malaria caused by Plasmodium berghei ANKA when used alone or in combination with established antimalarial drugs. Artemisone effects against P. falciparum in vitro were synergistic with halofantrine and mefloquine, and additive with 25 other drugs, including chloroquine and doxycycline. The concentrations of artemisone combinations that were toxic against THP-1 cells in vitro were much higher than their effective antimalarial concentration. Artemisone, mefloquine, chloroquine, or piperaquine given individually mostly protected mice against cerebral malaria caused by P. berghei ANKA but did not prevent parasite recrudescence. Combinations of artemisone with any of the other three drugs did completely cure most mice of malaria. The combination of artemisone and chloroquine decreased the ratio of proinflammatory (gamma interferon, tumor necrosis factor) to anti-inflammatory (interleukin 10 [IL-10], IL-4) cytokines in the plasma of P. berghei-infected mice. Thus, artemisone in combinations with other antimalarial drugs might have a dual action, both killing parasites and limiting the potentially deleterious host inflammatory response.

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Anxiety-like behavior and proinflammatory cytokine levels in the brain of C57BL/6 mice infected with Plasmodium berghei (strain ANKA)

Cited by 44 publications

References 29 publications

The significance of cerebral toxocariasis: a model system for exploring the link between brain involvement, behaviour and the immune response

The significance of cerebral toxocariasis: a model system for exploring the link between brain involvement, behaviour and the immune response

Memory deficit associated with increased brain proinflammatory cytokine levels and neurodegeneration in acute ischemic stroke

Treatment of Murine Cerebral Malaria by Artemisone in Combination with Conventional Antimalarial Drugs: Antiplasmodial Effects and Immune Responses

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