Anxiety Levels of Children with Developmental Disorders in Japan: Based on Reports Provided by Parents

Ishimoto, Yuma; Yamane, Takahiro; Matsumoto, Yuki

doi:10.1007/s10803-019-04092-z

Cited by 5 publications

(3 citation statements)

References 31 publications

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“…Thus, we have provided substantial evidence on the important contribution of PKMζ in BLA to the genesis of anxiety, in both normal mice and ASD model mice. Mounting clinical evidences indicate the prominent presence of anxiety in ASD patients (Ishimoto et al, 2019; Schiltz et al, 2019). We found that reducing PKMζ activity with ZIP peptide reduces anxiety in P35 VPA mice but not in P70 VPA mice.…”

Section: Discussionmentioning

confidence: 99%

Elevated Level of PKMζ Underlies the Excessive Anxiety in an Autism Model

Gao

Zheng

et al. 2019

Front. Mol. Neurosci.

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Anxiety affects the life quality of a significant percentage of autism patients. To understand the possible biological basis of this high anxiety level, we used a valproic acid (VPA) model of autism. Anxiety level is significantly higher in VPA-injected mice, at both P35 and P70. In addition, protein kinase Mζ (PKMζ) level in the basolateral amygdala (BLA) is significantly higher in VPA mice at both ages. Consistent with this finding, infusion of a PKMζ-blocking peptide z-pseudosubstrate inhibitory peptide (ZIP) into BLA significantly reduced anxiety levels in VPA mice. Furthermore, viral overexpression of PKMζ in the BLA led to elevated anxiety level in Wild Type (WT) mice, with concomitant higher intrinsic excitability of BLA excitatory neurons. Altogether, our results indicate a key contribution of BLA PKMζ level to anxiety, especially in autism; and this finding may provide a further understanding of the pathogenesis as well as treatment of anxiety symptoms in autism patients.

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Section: Discussionmentioning

confidence: 99%

Elevated Level of PKMζ Underlies the Excessive Anxiety in an Autism Model

Gao

Zheng

et al. 2019

Front. Mol. Neurosci.

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“…Autism Spectrum Disorder (ASD) is a pervasive neurodevelopmental disorder characterised by impairment in social communication and presence of restricted, repetitive patterns of behaviour, interests, or activities [2]. A growing body of research has shown that children with ASD experience significantly greater anxiety levels than typically developing children, as well as children with other developmental disorders [19,29,32,34,41,67]. A meta-analysis revealed that 39.6% of au-tistic young people were comorbid with at least one anxiety disorder [66].…”

Section: Introductionmentioning

confidence: 99%

Factors Associated with Anxiety Disorders in Chinese Children with Autism Spectrum Disorder in Hong Kong

JS,

CP,

2023

austinjpsychiatrybehavsci

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Background: Autism Spectrum Disorder (ASD) is a pervasive neurodevelopment disorder characterised by impairment in social communication and presence of restricted, repetitive patterns of behaviour, interests, or activities. A growing body of research has shown that children with ASD experience significantly greater anxiety levels than typically developing children. Anxiety disorders have been found to be one of the most prevalent psychiatric comorbidities in this population of children and are associated with debilitating psychosocial impairment. Objective: This study aimed to examine factors associated with anxiety disorders among Chinese children diagnosed with ASD in Hong Kong. Methods: This cross-sectional study was conducted at a child and adolescent psychiatry outpatient clinic from August 2019 to April 2020. The sample consisted of one hundred thirty-two subjects aged 6 to <12 years who had a diagnosis of ASD. Structured interviews and questionnaires including the Diagnostic Interview Schedule for Children, Parenting Stress Index-Short Form, Parenting Styles and Dimensions Questionnaire and a socio-demographic questionnaire were administered for the assessment of anxiety disorders and their associated factors. Results: Greater qualitative deficits in reciprocal social interaction skills, attention-deficit/hyperactivity disorder and maternal mood disorder were found to be significantly associated with anxiety disorders in children with ASD. Conclusion: Anxiety disorders are prevalent among children with ASD. Early recognition and identification of comorbid anxiety disorders are necessary in the diagnostic process of ASD. This study enriches our understanding of the factors associated with anxiety disorders in this population of children. For future research directions, furthering our understanding on the aetiological pathways, course of illness, and outcome of anxiety disorders in autistic children is highly warranted.

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“…In addition, high levels of anxiety have been observed among children with Attention Deficit Hyperactivity Disorder (ADHD), Learning Disabilities (LD) and Intellectual Disabilities (IDs). Researchers have found that children with ASD, in particular, had high levels of anxiety [1].…”

Section: Introductionmentioning

confidence: 99%

Anxiety management through hippotherapy in children with developmental disorders

Moscholouri¹,

Chandolias²

2021

Int. J. Sci. Res. Arch.

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A large number of children with developmental disorders show symptoms of anxiety compared to children with normal development. High levels of stress weaken relationships with people around these children, thus limiting the social interaction they may have. In addition to having higher anxiety overall, children with developmental disorders also have a higher comorbidity of anxiety with other disorders. Hippotherapy is an intervention, which uses the natural gait and movement of a horse to provide motor, and sensory stimulation. It is a unique treatment strategy for children with disabilities, as it improves movement coordination and posture control. By improving movement, children with disabilities gain confidence and sense of security which helps them to deal with stress.

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Anxiety Levels of Children with Developmental Disorders in Japan: Based on Reports Provided by Parents

Cited by 5 publications

References 31 publications

Elevated Level of PKMζ Underlies the Excessive Anxiety in an Autism Model

Elevated Level of PKMζ Underlies the Excessive Anxiety in an Autism Model

Factors Associated with Anxiety Disorders in Chinese Children with Autism Spectrum Disorder in Hong Kong

Anxiety management through hippotherapy in children with developmental disorders

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