Anxiety Disorders and Tic Severity in Juveniles With Tourette's Disorder

Coffey, Barbara J.; Biederman, Joseph; Smoller, Jordan W.; Geller, Daniel; Sarin, Priya; Schwartz, Suzanne; Kim, Grace S.

doi:10.1097/00004583-200005000-00009

Cited by 136 publications

(81 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There is no association between frequencies of OCD and severity of TS [14]. However, separation anxiety disorder most robustly predicts tic severity, irrespective of the presence of OCD or other anxiety disorders [14].…”

Section: Introductionmentioning

confidence: 84%

“…Many of the recently published studies have only focused on TS and ADHD and usually have not included other co-morbid psychiatric disorders such as separation anxiety disorder [9], ODD, and CD [10]. There is no association between frequencies of OCD and severity of TS [14]. However, separation anxiety disorder most robustly predicts tic severity, irrespective of the presence of OCD or other anxiety disorders [14].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cortisol and Treatment Effect in Children With Disruptive Behavior Disorders: A Preliminary Study

Wiel

Goozen

Matthys

et al. 2004

Journal of the American Academy of Child & Adolescent Psych

140

View full text Add to dashboard Cite

Objective: Many previous studies have surveyed associations between Tourette syndrome (TS) and co-morbid psychiatric disorders, but they usually did not include oppositional defiant disorder (ODD), conduct disorder (CD), separation anxiety disorder (SAD), and post-traumatic stress disorder (PTSD). Method: The subjects were children and adolescents with TS who visited a child and adolescent psychiatric clinic, and who were interviewed using DSM-IV diagnostic criteria. Characteristics of their tics were examined by the Yale-Global Tic Severity Scale (Y-GTSS). Behavioral problems were surveyed by the Child Behavior Checklist (CBCL) filled in by the parents. Results: About 87.9% of the subjects were boys. The mean age of the subjects was 11.8 years.The most common psychiatric disorders were attention deficit hyperactivity disorder (ADHD), ODD, nail biting, and obsessive compulsive disorder (OCD). Only one subject was affected by TS without co-morbidities. Among TS patients with co-morbidities, those with disruptive behavioral disorders (DBD) have significantly higher mean scores than patients without DBD on the Externalizing scale, Social problems, Attention problems, Delinquent and Aggression scales. Co-morbidity of anxiety disorders was not related to the CBCL scores. Conclusion: Many of our results were similar to those reported in studies conducted in other parts of the world. TS is more common in boys and nearly all of them had at least one co-morbid disorder. The most common co-morbidity was ADHD. Behavioral problems in TS are related to the co-morbidity with the DBD, and possibly not to the anxiety disorders.

show abstract

Section: Introductionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Cortisol and Treatment Effect in Children With Disruptive Behavior Disorders: A Preliminary Study

Wiel

Goozen

Matthys

et al. 2004

Journal of the American Academy of Child & Adolescent Psych

140

View full text Add to dashboard Cite

show abstract

“…Coffey et al 15 190 Unknown Descriptive study, signs and symptoms Psychiatric comorbidities are found in almost all patients with TS. ADHD and behavior disorders in general were the most prevalent comorbidities.…”

Section: Studies N=276mentioning

confidence: 99%

“…Leckman et al 8 In addition to OCD, all anxiety disorders, especially separation anxiety, were significantly associated with tic severity in patients with TS or TS+OCD+ADHD. 15,48 The association with anxiety disorders may have different reasons: tics improve with anxiolytic medication and worsen when children return to school (a stress factor) 15 ; neuroleptics may cause anxiety as an adverse reaction, which initiates or worsens tics; and comorbidities, such as ADHD, lead to anxiety disorders. 11 The hyperresponsiveness of the hypothalamic-pituitary axis may also explain the anxiety disorders found in TS.…”

Section: Ocd and Other Anxiety Disordersmentioning

confidence: 99%

See 1 more Smart Citation

Tourette's syndrome and associated disorders: a systematic review

Ferreira

Pio-Abreu

Januário

2014

Trends Psychiatry Psychother.

View full text Add to dashboard Cite

Objective: To compile data on Tourette's syndrome (TS), tics and associated disorders. Methods: A systematic review of the literature was conducted using the 5S levels of organization of healthcare research evidence (systems, summaries, synopses, syntheses, studies), based on the model described by Haynes. The search keywords were Tourette, tics and comorbidity, which were cross-referenced. Studies provided by publishers and articles being processed on July 31, 2013, were also included. Results: Of all studies retrieved during the search, 64 were selected because they analyzed the epidemiology, clinical features and etiopathogenesis of TS and its comorbidities. TS is classified as a hyperkinetic movement disorder, and at least 90% of the patients have neuropsychiatric comorbidities, of which attention deficit hyperactivity and obsessive-compulsive disorders are the most common. The syndrome is clinically heterogeneous and has been associated with a dysfunction of cortico-striatal-thalamic-cortical circuits involving various neurotransmitters. Although its genetic etiology has been widely studied, other factors may be important to understand this syndrome and its associated disorders. Conclusions: TS is a neurodevelopmental disorder that results from the impact of stress factors on a vulnerable biological substrate during the critical periods of neurodevelopment. The study of TS and its comorbidities may contribute, at different levels, to the understanding of several neuropsychiatric disorders of clinical and therapeutic relevance. Keywords: Attention deficit disorder with hyperactivity, comorbidity, obsessive-compulsive disorder, tics, Tourette's syndrome. ResumoObjetivo: Compilar o conhecimento existente sobre a síndrome de Tourette (ST), tiques e patologias associadas. Metodologia: Foi realizada uma revisão sistemática da literatura usando os níveis 5S (sistemas, sumários, sinopses, sínteses e estudos) de organização de evidência de pesquisa em saúde, com base no modelo proposto por Haynes. Os termos de busca foram Tourette, tiques e comorbidades, completados por pesquisa por referência cruzada. Os artigos fornecidos pelos editores e aqueles a serem processados para publicação em 31 de julho de 2013 também foram incluídos. Resultados: De todos os artigos encontrados durante a pesquisa, 64 foram selecionados porque analisavam a epidemiologia, as características clínicas e a etiopatogenia da ST. A ST define-se como um distúrbio hipercinético do movimento, e pelo menos 90% dos pacientes apresentam comorbidades neuropsiquiátricas, das quais as mais comuns são a perturbação de déficit de atenção com hiperatividade e a perturbação obsessivo--compulsiva. Esta síndrome é clinicamente heterogênea e tem sido relacionada com a disfunção dos circuitos córtico-estriado--tálamo-corticais envolvendo vários neurotransmissores. Apesar de sua etiologia genética ter sido amplamente estudada, outros fatores podem ser importantes para entender esta síndrome e as perturbações relacionadas. Conclusões: A ST resulta de uma p...

show abstract