Anxiety Disorders among Methamphetamine Dependent Adults: Association with Post‐Treatment Functioning

Glasner‐Edwards, Suzette; Mooney, Larissa; Marinelli‐Casey, Patricia; Hillhouse, Maureen; Ang, Alfonso; Rawson, Richard A.

doi:10.1111/j.1521-0391.2010.00061.x

Cited by 77 publications

(57 citation statements)

References 30 publications

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“…Although METH is linked to impaired decision-making, individual differences in comorbid psychopathology, particularly anxiety, adversely impact treatment outcomes in METH (Glasner-Edwards et al, 2010). Anxiety symptoms, often heightened in METH (Gonzales et al, 2010; London et al, 2004; Salo et al, 2011), are linked to greater AI activation to aversive stimuli and risky decisions (Hartley and Phelps, 2012; Paulus and Stein, 2010; Simmons et al, 2011; Stein et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

You are the danger: Attenuated insula response in methamphetamine users during aversive interoceptive decision-making

Stewart

May

Poppa

et al. 2014

Drug and Alcohol Dependence

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Background Drug dependent individuals often make drug-taking decisions when they do not feel well. Yet, few studies have examined the influence of an aversive state on decision-making related neural processing. Methods We investigate brain activation to decision-making during an aversive interoceptive challenge in methamphetamine users using functional magnetic resonance imaging (fMRI). Recently abstinent inpatients with methamphetamine use disorder (METH; n=20) and healthy comparison subjects (CTL; n=22) performed a two-choice prediction task at three fixed error rates (ER; 20%=reward, 50%=uncertainty, 80%=punishment) while anticipating and experiencing episodes of inspiratory breathing load during fMRI. Results METH exhibited higher trait anxiety in conjunction with lower anterior insula (AI) and inferior frontal gyrus (IFG) activation than CTL across trials. METH also showed lower posterior insula (PI) and anterior cingulate cortex (ACC) activation than CTL during breathing load independent of ER. For the crucial ER by interoception interaction, METH displayed lower ACC activation to punishment/loss than CTL during breathing load. Within METH, lower trait anxiety was linked to bilateral AI/IFG attenuation across trials. Conclusions AI/IFG attenuations in METH are suggestive of an executive functioning deficit, particularly in users with low anxiety, reflecting reduced resources allocated to choice selection. In contrast, PI/ACC reductions in METH appear specific to impairments in registering and evaluating interoceptive experiences. Taken together, inadequate activation of brain areas that are important for regulating when one does not feel well may be the neural basis for poor decision-making by METH.

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Section: Introductionmentioning

confidence: 99%

You are the danger: Attenuated insula response in methamphetamine users during aversive interoceptive decision-making

Stewart

May

Poppa

et al. 2014

Drug and Alcohol Dependence

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“…The relationship between the symptoms of depression and methamphetamine intoxication and withdrawal complicates diagnosing major depressive disorder (MDD; Langa s, Malt, & Opjordsmoen, 2011) and measuring depression severity in methamphetamine users due to overlap in symptoms of depression and intoxicating effects of methamphetamine. Regardless, a diagnosis of depression among individuals who use methamphetamine confounds treatment outcomes (Stein et al, 2004;Glasner-Edwards, Mooney, Marinelli-Casey, Hillhouse, Ang, & Rawson, 2010).…”

Section: Introductionmentioning

confidence: 99%

Preliminary Psychometric Evaluation of the Hamilton Depression Rating Scale in Methamphetamine Dependence

Hellem

Scholl

Sung

et al. 2017

Journal of Dual Diagnosis

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Objective: The purpose of this study was to test the initial psychometric properties of the 17-item Hamilton Depression Rating Scale (HAM-D) in individuals with and without major depressive disorder who use methamphetamine. We used data from two completed studies and two ongoing clinical trials. The HAM-D has well established reliability and validity in a variety of populations. However, there are no published reports of reliability and validity of the HAM-D in a methamphetamine-using population. Methods: HAM-D and depression status data were extracted from four separate studies for this psychometric assessment. Using these data, we evaluated three measures of construct validity: internal consistency, contrasted group validity, and factorial validity. Results: We found potential concerns with the construct validity of the HAM-D in users of methamphetamine. Intercorrelations between items were primarily less than 0.20 and the Cronbach's alpha value in this sample was 0.58, indicating potential issues with internal consistency. The results of two-sample t-tests suggest concerns with contrasted group validity, as no significant difference in average scores were found for nine items. Consistent with previous studies, a principal component analysis indicates that the HAM-D is multidimensional. Conclusions: The 17-item HAM-D might not reliably and validly measure depression severity in a methamphetamine-using population. Given our small sample, additional research is needed, though, to further test the psychometric properties of the HAM-D in individuals who use methamphetamine.

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“…One of the few studies of psychiatric severity among MA dependent persons receiving treatment was reported by Glasner-Edwards 14 . Using data from 526 adults in a large clinical trial of MA users they found the presence of psychiatric disorders post treatment was associated with more MA use post treatment.…”

Section: Introductionmentioning

confidence: 99%

Changes in Psychiatric Symptoms among Persons with Methamphetamine Dependence Predicts Changes in Severity of Drug Problems but Not Frequency of Use

et al. 2016

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Background Few studies have examined how changes in psychiatric symptoms over time are associated with changes in drug use and severity of drug problems. No studies have examined these relationships among methamphetamine (MA) dependent person receiving motivational interviewing within the context of standard outpatient treatment. Methods Two hundred seventeen individuals with MA dependence were randomly assigned to a standard single session of motivational interviewing (MI) or an intensive 9-session model of MI. Both groups received standard outpatient group treatment. The Addiction Severity Index (ASI) and time-line-follow-back (TLFB) for MA use were administered at treatment entry and 2-, 4- and 6-month follow-up. Results Changes in ASI psychiatric severity between baseline and 2 months predicted changes in ASI drug severity during the same time-period, but not changes on measures of MA use. Item analysis of the ASI drug scale showed psychiatric severity predicted how troubled or bothered participants were by their drug us, how important they felt it was for them to get treatment, and the number of days they experienced drug problems. However, it did not predict the number days they used drugs the past 30 days. These associations did not differ between study conditions and they persisted when we compared psychiatric severity and outcomes across 4- and 6-month time periods. Conclusion Results are among the first to track how changes in psychiatric severity over time are associated with changes in MA use and severity of drug problems. Treatment efforts targeting reduction of psychiatric symptoms among MA dependent persons might be helpful in reducing the level of distress and problems associated with MA use but not how often it is used. There is a need for additional research describing the circumstances under which the experiences and perceptions of drug related problems diverge from frequency of consumption.

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Anxiety Disorders among Methamphetamine Dependent Adults: Association with Post‐Treatment Functioning

Cited by 77 publications

References 30 publications

You are the danger: Attenuated insula response in methamphetamine users during aversive interoceptive decision-making

You are the danger: Attenuated insula response in methamphetamine users during aversive interoceptive decision-making

Preliminary Psychometric Evaluation of the Hamilton Depression Rating Scale in Methamphetamine Dependence

Changes in Psychiatric Symptoms among Persons with Methamphetamine Dependence Predicts Changes in Severity of Drug Problems but Not Frequency of Use

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