Anxiety, depression and sleepiness in OSA patients treated with barbed reposition pharyngoplasty: a prospective study

Ferlito, S; Lechien, Jérôme R.; Luca, Milena Di; Iannella, Giannicola; Cammaroto, Giovanni; Cannavicci, Angelo; Pollicina, Isabella; Stilo, Giovanna; Mauro, Paola Di; Magliulo, Giuseppe; Pace, Annalisa; Vicini, Claudio

doi:10.1007/s00405-022-07369-9

Cited by 12 publications

(14 citation statements)

References 50 publications

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“…NAFLD, the most prevalent chronic liver disease worldwide, involves hepatic fat accumulation and is strongly associated with obesity [8]. Likewise, OSA is marked by recurrent sleep airway obstruction, and therefore patients with OSA may benefit from treatment like palate surgery, reducing not only the apnea and hypopnea indices and daytime sleepiness but also associated with mood comorbidities [50]. OSA is closely tied to obesity [9].…”

Section: Discussionmentioning

confidence: 99%

Periodontitis and Metabolic Syndrome: Statistical and Machine Learning Analytics of a Nationwide Study

Wilensky,

Frank,

Mizraji

et al. 2023

Bioengineering

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This study aimed to analyze the associations between periodontitis and metabolic syndrome (MetS) components and related conditions while controlling for sociodemographics, health behaviors, and caries levels among young and middle-aged adults. We analyzed data from the Dental, Oral, and Medical Epidemiological (DOME) record-based cross-sectional study that combines comprehensive sociodemographic, medical, and dental databases of a nationally representative sample of military personnel. The research consisted of 57,496 records of patients, and the prevalence of periodontitis was 9.79% (5630/57,496). The following parameters retained a significant positive association with subsequent periodontitis multivariate analysis (from the highest to the lowest OR (odds ratio)): brushing teeth (OR = 2.985 (2.739–3.257)), obstructive sleep apnea (OSA) (OR = 2.188 (1.545–3.105)), cariogenic diet consumption (OR = 1.652 (1.536–1.776)), non-alcoholic fatty liver disease (NAFLD) (OR = 1.483 (1.171–1.879)), smoking (OR = 1.176 (1.047–1.322)), and age (OR = 1.040 (1.035–1.046)). The following parameters retained a significant negative association (protective effect) with periodontitis in the multivariate analysis (from the highest to the lowest OR): the mean number of decayed teeth (OR = 0.980 (0.970–0.991)); North America as the birth country compared to native Israelis (OR = 0.775 (0.608–0.988)); urban non-Jewish (OR = 0.442 (0.280–0.698)); and urban Jewish (OR = 0.395 (0.251–0.620)) compared to the rural locality of residence. Feature importance analysis using the eXtreme Gradient Boosting (XGBoost) machine learning algorithm with periodontitis as the target variable ranked obesity, OSA, and NAFLD as the most important systemic conditions in the model. We identified a profile of the “patient vulnerable to periodontitis” characterized by older age, rural residency, smoking, brushing teeth, cariogenic diet, comorbidities of obesity, OSA and NAFLD, and fewer untreated decayed teeth. North American-born individuals had a lower prevalence of periodontitis than native Israelis. This study emphasizes the holistic view of the MetS cluster and explores less-investigated MetS-related conditions in the context of periodontitis. A comprehensive assessment of disease risk factors is crucial to target high-risk populations for periodontitis and MetS.

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Section: Discussionmentioning

confidence: 99%

Periodontitis and Metabolic Syndrome: Statistical and Machine Learning Analytics of a Nationwide Study

Wilensky,

Frank,

Mizraji

et al. 2023

Bioengineering

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“…Other sleep disorders, like chronic lack of sleep, fragmented sleep, and sleep deprivation, may also be important risk factors for cardiovascular disorders [ 2 ] So far, most of the literature regarding the relationship between sleep and ischemic stroke has focused primarily on obstructive sleep apnea [ 5 ]. For sleep breathing disorders, often strongly correlated with elevated BMI and various cardiovascular, metabolic, or central nervous system issues [ 6 ], their amelioration potentially reduces daytime sleepiness, improving associated mood comorbidities like depression and anxiety [ 7 ]. However, a growing body of evidence shows that sleep disorders, including insomnia and unfavorable sleep habits, are associated with a rise in the occurrence of vascular events, such as ischemic stroke [ 8 , 9 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Insomnia–Ischemic Stroke Nexus: A Comprehensive Review

Matas,

Pinto,

Conde

et al. 2024

JCM

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Background: This study investigates the relationship between sleep patterns and ischemic stroke beyond the predominant focus on obstructive sleep apnea. Through a systematic review of the existing literature, we aim to elucidate the connections between insomnia, sleep duration, cardiovascular factors, and ischemic stroke onset. Methods: We searched databases, including MEDLINE, SciELO, Scopus, and Science Direct, using an adapted PICO framework. Using a search strategy with MeSH words, keywords, and expressions related to insomnia and stroke, we included clinical trials and analytical observational epidemiological studies, comprising cohort, case–control, and cross-sectional studies. Results: Following the initial search, we identified 984 records, with 779 titles and abstracts screened for eligibility after removing duplicates. From these, 63 full-text articles, including 5 in the data synthesis, were reviewed. Our findings highlight a significant correlation between poor sleep quality, extreme sleep durations, and a heightened risk of ischemic stroke, along with established cardiovascular risk factors, such as hypertension, hyperlipidemia, obesity, and diabetes. Conclusions: This systematic review offers a comprehensive analysis of ischemic stroke prevalence and its association with cardiovascular factors, such as hypertension, hyperlipidemia, obesity, and diabetes. It suggests that poor sleep quality and extreme sleep durations, particularly long ones, are linked to a heightened risk of ischemic stroke.

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“…SAS is linked to several complications and afflicts many patients. Some of those complications include obesity [2,3], type 2 diabetes [4][5][6][7], dyslipidemia [8,9], dementia [10,11], mood disorders [12], and, especially, hypertension [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Possible Molecular Mechanisms of Hypertension Induced by Sleep Apnea Syndrome/Intermittent Hypoxia

Takeda,

Kimura,

Takasawa

2024

Life

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Intermittent hypoxia (IH) is a central characteristic of sleep apnea syndrome (SAS), and it subjects cells in the body to repetitive apnea, chronic hypoxia, oxygen desaturation, and hypercapnia. Since SAS is linked to various serious cardiovascular complications, especially hypertension, many studies have been conducted to elucidate the mechanism of hypertension induced by SAS/IH. Hypertension in SAS is associated with numerous cardiovascular disorders. As hypertension is the most common complication of SAS, cell and animal models to study SAS/IH have developed and provided lots of hints for elucidating the molecular mechanisms of hypertension induced by IH. However, the detailed mechanisms are obscure and under investigation. This review outlines the molecular mechanisms of hypertension in IH, which include the regulation systems of reactive oxygen species (ROS) that activate the renin–angiotensin system (RAS) and catecholamine biosynthesis in the sympathetic nervous system, resulting in hypertension. And hypoxia-inducible factors (HIFs), Endotheline 1 (ET-1), and inflammatory factors are also mentioned. In addition, we will discuss the influences of SAS/IH in cardiovascular dysfunction and the relationship of microRNA (miRNA)s to regulate the key molecules in each mechanism, which has become more apparent in recent years. These findings provide insight into the pathogenesis of SAS and help in the development of future treatments.

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Anxiety, depression and sleepiness in OSA patients treated with barbed reposition pharyngoplasty: a prospective study

Cited by 12 publications

References 50 publications

Periodontitis and Metabolic Syndrome: Statistical and Machine Learning Analytics of a Nationwide Study

Periodontitis and Metabolic Syndrome: Statistical and Machine Learning Analytics of a Nationwide Study

Exploring the Insomnia–Ischemic Stroke Nexus: A Comprehensive Review

Possible Molecular Mechanisms of Hypertension Induced by Sleep Apnea Syndrome/Intermittent Hypoxia

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