Anxiety, depression, and quality of life in Parkinson’s disease: the implications of multidisciplinary treatment

Abstract

Anxiety and depression in Parkinson’s disease (PD) reduce well-being of the patients. Emotional alterations influence motor skills and cognitive performance; moreover, they contribute significantly and independently to worsen rehabilitative treatment response. We investigated anxiety, depression, and quality of life in PD patients subjected to multidisciplinary rehabilitative training. The self-controlled study included 100 PD patients (49 males and 51 females with the mean age of 64.66 years) admitted to 60 days hospitalization rehabilitative program, between January 2017 and December 2018. Motor, cognitive, linguistic abilities, and functional independence were evaluated at admission (T0 baseline visit) and 60 days after (T1) the multidisciplinary rehabilitation including motor exercises, speech therapies, and cognitive intervention. The multidisciplinary rehabilitation improved functional status in PD patients and exerted its positive effects on mood, motor abilities, autonomy in the activities of daily life, perception of quality of life, cognitive performance and speech skills. Non-motor symptoms may worsen severe disability and reduce quality of life. They are often poorly recognized and inadequately treated. Nonetheless, multidisciplinary rehabilitative training represents an optimal strategy to improve disease management. The study was approved by Istituito di Ricovero e Cura a Carattere Scientifico (IRCCS) Centro Neurolesi “Bonino-Pulejo” Ethical Committee (approval No. 6/2016) in June 2016.

A meta-analysis of the effect of multidisciplinary comprehensive care on health-related quality of life and Unified Parkinson’s Disease Rating Scale in Parkinson’s disease

“…From a total of 1234 examined studies, 7 articles published between 2003 and 2021 that met the requirements and were included in the meta-analysis were selected. [48][49][50][51][52][53][54] Table 2 presents the findings from these studies. A total of 1115 subjects with PD participated in the selected studies' baseline trials; 633 of them underwent multidisciplinary comprehensive care, while 482 were provided with standard care.…”

“…In the trials included in this meta-analysis, 1115 subjects with PD participated in baseline trials; 633 of them received multidisciplinary comprehensive care, while 482 were provided with standard care. [48][49][50][51][52][53][54] The use of multidisciplinary comprehensive care resulted in significantly better HRQL and UPDRS compared to the standard care for subjects with PD. Nevertheless, no significant difference was found between multidisciplinary comprehensive care and standard care for subjects with PD in terms of medication dosage and caregiver strain.…”

Research on depression in Parkinson disease: A bibliometric and visual analysis of studies published during 2012–2021

“…Cognitive training includes specific exercises for attention/working memory, psychomotor speed, executive function, visuospatial ability, computational skills, paper-and-pencil, and computerized tasks. [18] In addition, physical, occupational, and speech therapies can also be useful. [19] Therapeutic interventions can help maintain or improve motor symptoms, balance, gait, and function, and ameliorate hypovocalization and dysphagia.…”

“…Multidisciplinary rehabilitation improved the functional status of PD patients and had a positive impact on mood, motor ability, autonomy of activities of daily living, perception of quality of life, cognitive ability, and speech skills. [18] Referral and consultation with multidisciplinary treatment is an important part of high-quality care for PD. [20] The construction of the Parkinson anxiety scale was the largest cluster in this study.…”

A Brief Analysis on the Modulation Effect of Ba Duan Jin on Non-Motor Symptoms of Parkinson’s Disease

“…PD non-motor symptoms not only reduce the quality of life of patients (Chuquilín-Arista, F., T. Álvarez-Avellón & M. Menéndez-González, 2020), but also affect the treatment effect of motor symptoms (Nodehi, Z., et al, 2021), aggravate disease progression, and form a vicious circle. Studies (Lo Buono, V., et al, 2021) have pointed out that patients with PD with non-motor symptoms such as anxiety and depression show more severe dyskinesia and lower well-being than patients with motor symptoms alone. Nonmotor symptoms may increase the risk of suicide from PD, which is already difficult (Chen, Y.Y., et al, 2021).…”