Anxiety, depression, and insomnia

Larzelere, Michele M.; Wiseman, Pamela

doi:10.1016/s0095-4543(01)00003-3

Cited by 35 publications

(29 citation statements)

References 98 publications

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“…Similarly, coumarin may provide additive blood thinning effects to the antiplatelet or hypoprothrombinemic actions of aspirin, other non-steroidal antiinflammatory drugs, and/or acetaminophen when used concomitantly (Abebe, 2002). Due to its mild sedative effect, chamomile also has the potential to increase the CNS depressant effects of other sedative drugs such as opioid analgesics, BDZ or alcohol and, therefore, a contraindication has been suggested in conjunction with these agents (O'Hara et al, 1998;Abebe, 2002;Larzelere and Wiseman, 2002).…”

Section: Adverse Reactions/toxicitymentioning

confidence: 99%

A Review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.)

McKay

Blumberg

2006

Phytotherapy Research

585

372

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Chamomile (Matricaria recutita L., Chamomilla recutita L., Matricaria chamomilla) is one of the most popular single ingredient herbal teas, or tisanes. Chamomile tea, brewed from dried flower heads, has been used traditionally for medicinal purposes. Evidence-based information regarding the bioactivity of this herb is presented. The main constituents of the flowers include several phenolic compounds, primarily the flavonoids apigenin, quercetin, patuletin, luteolin and their glucosides. The principal components of the essential oil extracted from the flowers are the terpenoids alpha-bisabolol and its oxides and azulenes, including chamazulene. Chamomile has moderate antioxidant and antimicrobial activities, and significant antiplatelet activity in vitro. Animal model studies indicate potent antiinflammatory action, some antimutagenic and cholesterol-lowering activities, as well as antispasmotic and anxiolytic effects. However, human studies are limited, and clinical trials examining the purported sedative properties of chamomile tea are absent. Adverse reactions to chamomile, consumed as a tisane or applied topically, have been reported among those with allergies to other plants in the daisy family, i.e. Asteraceae or Compositae.

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Section: Adverse Reactions/toxicitymentioning

confidence: 99%

A Review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.)

McKay

Blumberg

2006

Phytotherapy Research

585

372

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“…Insomnia is a heterogeneous disorder that entails difficulties with sleep onset, maintenance and early morning wakening [5]. Subjective complaints of decreased duration of sleep or diminished sleep quality, depth and efficiency are also typical definitions of insomnia [6]. …”

Section: Introductionmentioning

confidence: 99%

Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances

Cases¹,

Ibarra²,

Feuillère³

et al. 2010

Mediterr J Nutr Metab

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Botanicals are an alternative option to prescription drugs for the alleviation of symptoms due to anxiety disorders and insomnia. Melissa officinalis L. has been shown as an anti-stress and anxiolytic agent. We previously reported moderate stress improvement in mice in which Cyracos®, a standardized Melissa officinalis L. extract, was administrated. Cyracos® contains phytochemicals that inhibit gamma-aminobutyric acid catabolism. This was a prospective, open-label, 15-day study to evaluate the efficacy of Cyracos® on stressed volunteers, who have mild-to-moderate anxiety disorders and sleep disturbances. Using clinician rating criteria, primary outcomes showed improvement of symptoms. Cyracos® reduced anxiety manifestations by 18% (p < 0.01), ameliorated anxiety-associated symptoms by 15% (p < 0.01) and lowered insomnia by 42% (p < 0.01). As much as 95% of subjects (19/20) responded to treatment, of which 70% (14/20) achieved full remission for anxiety, 85% (17/20) for insomnia, and 70% (14/20) for both. Our study demonstrates, for the first time that chronic administration of Melissa officinalis L. relieves stress-related effects. It is critical that further studies incorporate a placebo and investigate physiological stress markers.

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“…Although used in different pharmaceutical preparations according to the need (Tubaro et al, 1984;Mann & Staba, 1986;Maiche et al, 1991;Fidler et al, 1996;Li et al, 1996), chamomile has largely been consumed as a tea or infusion for sedative and anxiolytic purposes (Viola et al, 1995;Cauffield & Forbes, 1999;Larzelere & Wiseman, 2002) as well as a digestive aid to treat gastrointestinal disturbances, particularly in children (Weizman et al, 1993;de la Motte et al, 1997;Mills & Bone, 2000;Madisch et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

In Vitro Antichemotactic Activity of Chamomilla recutita Hydroethanol Extract

Presibella

Santos

Weffort-Santos

2007

Pharmaceutical Biology

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In this study, we have investigated the ability of the hydroethanolic extract prepared from the flower heads of Chamomilla recutita (L.) Rauschert (Asteraceae) to interfere with human leukocyte chemotaxis induced by casein using the in vitro Boyden system. The results showed a striking dose-related inhibition of the caseininduced human polymorphonuclear leukocyte migration after chamomile extract treatment in comparison with untreated controls, a biological effect never reported before for this ancient plant. Moreover, these effects were similar to those showed by dexamethasone, a model drug. Of particular interest are the results observed after pretreating these cells with morphine, in which the antichemotactic activity could be partially blocked, suggesting that these effects might be opioid receptor mediated. The data herein presented may be useful to clarify the worldwide use of this herbal medicine as an oral infusion, supporting its ethnomedical application as a calming, spasmolytic, and anti-inflammatory agent.

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Anxiety, depression, and insomnia

Cited by 35 publications

References 98 publications

A Review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.)

A Review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.)

Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances

In Vitro Antichemotactic Activity of Chamomilla recutita Hydroethanol Extract

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