Anxiety, Depression, and Health-Related QOL in Patients Diagnosed with PAH or CTEPH

Pfeuffer, Elena; Krannich, Holger; Halank, Michael; Wilkens, Heinrike; Kolb, Philipp; Jany, B; Held, Matthias

doi:10.1007/s00408-017-0052-z

Cited by 28 publications

(42 citation statements)

References 61 publications

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“…Pfeuffer et al suggest an important difference in the prevalence of anxiety, depression, and perception of health-related quality of life (HRQoL) between chronic thromboembolic pulmonary hypertension (CTEPH) and PAH patients, with higher scores in CTEPH cohorts. 20 …”

Section: Resultsmentioning

confidence: 99%

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Anxiety and depression in patients with pulmonary hypertension: impact and management challenges

Bussotti¹,

Sommaruga²

2018

VHRM

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BackgroundAnxiety and depression are frequent disorders in patients with pulmonary arterial hypertension (PAH), but despite this only less than one-fourth of them is treated. Our aim was to review the studies regarding the prevalence and the impact of anxiety and depression and to propose management challenges.MethodsA literature review regarding 1) anxiety and depression studies in PAH patients and caregivers, 2) psychological interventions, 3) slow breathing approach, and 4) pharmacological approach was performed, based on evidence of effectiveness through a search of the most well-known databases (Cochrane Library, Medline, PsychINFO [2004–2018]).ResultsThe prevalence of mental disorders in PAH patients lies between 7.5% and 53% for depression and 19% and 51% for anxiety and panic disorders. The latest guidelines of the European Society of Cardiology recommend a psychological support with a class of recommendation I and a level of evidence c. The analysis of psychological intervention shows that at present there is no evidence of specific psychological interventions in these patients. However, treatment approaches based on other chronic illnesses are suggested, especially based on relaxation training, slow breathing, and cognitive behavioral therapy. Finally, data concerning the use of antidepressant drugs are conflicting.ConclusionFirstly, our data demonstrate a common underestimation of mental disorders by health professionals and secondly, the need of implementing appropriate methods of screening for mental disorders in PAH patients. However, the paucity of large observational studies in this area requires the attention of researchers. The evidence about optimal approaches for managing anxiety and depression in PAH also remains unclear and largely speculative. The challenge is the introduction of routine psychological intervention, as suggested by the European Society of Cardiology and already applied in other chronic disease.

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Section: Resultsmentioning

confidence: 99%

“…Harzheim et al confirmed a little difference in anxiety and depression prevalence between PAH (22.5%) and CTEPH (25%) patients, but we must outline that the cohorts analyzed by Harzheim were younger than patients studied by Pfeuffer. 17 , 20 …”

Section: Resultsmentioning

confidence: 99%

Anxiety and depression in patients with pulmonary hypertension: impact and management challenges

Bussotti¹,

Sommaruga²

2018

VHRM

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“… 7 The results of our study reveal that in addition to the multiple impacts mentioned above, patients with PH are also likely to experience psychological states of anxiety, depression, worthlessness, uncertainty about the future, and hopelessness. 5 , 21 , 22 Although past studies have pointed out the importance of psychiatric referrals in patients with PH, 20 , 23 one study has shown that the percentage of patients with PH with psychological and emotional disturbances undergoing psychiatric treatment is low. 24 Our study finds that the underlying cause of the low percentage of psychiatric treatment involved is not that the medical team fails to notice the patients’ psychological and emotional disturbances.…”

Section: Discussionmentioning

confidence: 99%

Exploring the experiences and psychosocial stresses of Taiwanese patients with pulmonary hypertension: a qualitative interview study

Chiang

Couper

et al. 2018

Pulm. circ.

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About half of all patients with pulmonary hypertension (PH) experience psychological and emotional disturbances that affect their quality of life (QOL). There is a lack of studies exploring how psychiatric professionals can provide specific and effective mental health treatment to patients with PH. This study aimed to explore and understand the treatment experiences of patients with PH in Taiwan. We employed an exploratory qualitative design involving interviews with 17 patients with PH who were treated at Kaohsiung Veterans General Hospital in Taiwan. Participants were interviewed by a psychiatrist; the interviews were audiotaped and transcribed for thematic analysis by two researchers. We corroborate earlier findings showing that patients who have the rare disease PH often experience psychological or emotional disturbances throughout the treatment process. This study explored a model for psychiatric intervention based on patients’ experience of having PH. We find that assessing and strengthening links to external resources can enhance patients’ long-term coping abilities, and thereby help reduce their psychological and emotional disturbances and improve their QOL.

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“…spinal cord injury, interstitial lung disease, or treatment-resistant cancer [16]. An interesting comparison of quality of life (QoL) in PAH and chronic thromboembolic pulmonary hypertension (CTEPH) patients was presented by Pfeuffer et al [17]. CTEPH is a rare, progressive pulmonary vascular disease, that is usually a consequence of prior acute pulmonary embolism [18].…”

Section: Quality Of Lifementioning

confidence: 99%

“…While both cohorts of patients suffered from a reduced HRQoL as well as depression and anxiety, decreases in mental health parameters were more pronounced in the CTEPH cohort. This suggests the need for intensive efforts to improve early detection, especially in dyspnoeic patients with classical risk factors for PAH and CTEPH and mental health interventions alongside routine clinical care provided to patients diagnosed with PAH or CTEPH [17].…”

Section: Quality Of Lifementioning

confidence: 99%

The importance of psychosocial factors in management of pulmonary arterial hypertension patients

Sobczak-Kaleta

Torbicki²,

Kasprzak

2018

Kardiol Pol

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Anxiety, Depression, and Health-Related QOL in Patients Diagnosed with PAH or CTEPH

Cited by 28 publications

References 61 publications

Anxiety and depression in patients with pulmonary hypertension: impact and management challenges

Anxiety and depression in patients with pulmonary hypertension: impact and management challenges

Exploring the experiences and psychosocial stresses of Taiwanese patients with pulmonary hypertension: a qualitative interview study

The importance of psychosocial factors in management of pulmonary arterial hypertension patients

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