Anxiety correlates with somatic symptoms and sleep status at high altitudes

Dong, Jun-Qing; Zhang, Jihang; Qin, Jun; Li, Qian-ning; Huang, Wen; Gao, Xubin; Yu, Jie; Chen, Guozhu; Tang, Xu-gang; Huang, Lan

doi:10.1016/j.physbeh.2013.02.001

Cited by 36 publications

(35 citation statements)

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“…Constant worrying and chronic anxiety may also lead to insomnia as frequent arousals may contribute to sleep fragmentation. Anxiety and insomnia are closely related clinical entities (Brown et al, 2013; Dong et al, 2013; Lee et al, 2013). This relationship could be associated with an increased propensity to sigh, a possibility that deserves further investigations.…”

Section: When Sighs Enhance Breathing Variability and Induce Hyperamentioning

confidence: 99%

The Integrative Role of the Sigh in Psychology, Physiology, Pathology, and Neurobiology

Ramirez

2014

Progress in Brain Research

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“Sighs, tears, grief, distress” expresses Johann Sebastian Bach in a musical example for the relationship between sighs and deep emotions. This review explores the neurobiological basis of the sigh and its relationship with psychology, physiology, and pathology. Sighs monitor changes in brain states, induce arousal, and reset breathing variability. These behavioral roles homeostatically regulate breathing stability under physiological and pathological conditions. Sighs evoked in hypoxia evoke arousal and thereby become critical for survival. Hypoarousal and failure to sigh have been associated with sudden infant death syndrome. Increased breathing irregularity may provoke excessive sighing and hyperarousal, a behavioral sequence that may play a role in panic disorders. Essential for generating sighs and breathing is the pre-Bötzinger complex. Modulatory and synaptic interactions within this local network and between networks located in the brainstem, cerebellum, cortex, hypothalamus, amygdala, and the periaqueductal gray may govern the relationships between physiology, psychology, and pathology. Unraveling these circuits will lead to a better understanding of how we balance emotions and how emotions become pathological.

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Section: When Sighs Enhance Breathing Variability and Induce Hyperamentioning

confidence: 99%

The Integrative Role of the Sigh in Psychology, Physiology, Pathology, and Neurobiology

Ramirez

2014

Progress in Brain Research

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“…From these results, we can assume that active SLE patients at higher plateaus might have a tendency to develop more severe CNS manifestations. Much research on chronic mountain diseases indicates that the pathological process of CNS and psychological changes can occur with elevation due to chronic hypoxia, 33 which is a plausible explanation for increasing CNS activity with elevations in altitude when SLE is active.…”

Section: Discussionmentioning

confidence: 99%

Systemic lupus erythematosus patients in the low-latitude plateau of China: altitudinal influences

Qian

Ran

Zhou

et al. 2014

Lupus

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The current study was to investigate the features of hospitalized patients with systemic lupus erythematosus (SLE) at different altitudes. The correlation between SLE activity and altitudinal variations was also explored. Medical records of 1029 patients were retrospectively reviewed. Activity of SLE in each organ system was recorded using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). There was no significant correlation between SLE activity and altitudes (r = 0.003, p = 0.159). Age at onset for SLE patients at high altitudes was significantly younger than that at low and moderate altitudes (p = 0.022 and p = 0.004, respectively). Age at SLE admission at low altitudes was significant older than those at moderate and high altitudes (p = 0.011 and p < 0.001, respectively). Patients at high altitudes had shorter duration from disease onset to admission than those at moderate altitudes (p = 0.009). Incidence of Sm antibodies-positive for resident patients at high altitudes was 36.4%, which were higher than that at moderate altitudes (p = 0.003). We found increasing trends of CNS activity in active patients; immunological and renal activities in inactive patients were correlated with elevated altitudes (p = 0.024, p = 0.004, p = 0.005), while arthritis scores in active patients showed the tendency of decreasing with the rise of elevation (p = 0.002). Hemoglobin level, red blood cell and platelet counts at high altitudes were significantly lower than those at low altitudes (p < 0.05, respectively). There was no significant difference in hemoglobin level between moderate- and low-altitude groups (p > 0.05). No significant difference in platelet counts between moderate- and high-altitude groups was observed (p > 0.05). Our findings suggest that some clinical features, laboratory tests and activity of main organs in SLE are influenced by altitudes. Furthermore, organ activities of active and inactive SLE patients have different patterns of altitudinal variations. These distinctive variations likely reveal that peculiar environmental factors at high altitudes can affect the development of SLE.

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“…Behavioral impairments caused by ascent to high altitudes can thus affect various operations, since both rate of performance and judgment are affected 8,10…”

Section: Introductionmentioning

confidence: 99%

Mood changes at very high altitudes in Pakistan

Ahmad

Hussain

2017

Pak J Med Sci

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Objective:To screen out psychiatric ‘cases’ and find the frequency of anxiety and depression symptoms in military volunteers performing duties at very high altitudes in the Karakoram ranges of Pakistan.Methods:This was a descriptive study lasting from Jan 2015 to June 2015, on volunteers serving at very high altitude, using General Health Questionnaire-12 (GHQ-12) and Hospital Anxiety and Depression Scale (HADS), Urdu versions. Analysis involved descriptive, inferential techniques and Bonferroni test. Demographic variables were compared to the scores.Results:A high percentage of the military volunteers screened positive for psychiatric ‘caseness’ and symptoms of anxiety and depression; mostly in the mild to moderate range, while very few of them reported severe symptoms. Demographic variables such as marital status, number of children, positive family psychiatric history, past medical history, duration at high altitude and educational levels were found to be significant risk factors for developing symptoms of anxiety and depression.Conclusions:Individuals performing duties at very high altitude, experience symptoms of anxiety and depression, their demographics are important in understanding their emotional problems.

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Anxiety correlates with somatic symptoms and sleep status at high altitudes

Cited by 36 publications

References 36 publications

The Integrative Role of the Sigh in Psychology, Physiology, Pathology, and Neurobiology

The Integrative Role of the Sigh in Psychology, Physiology, Pathology, and Neurobiology

Systemic lupus erythematosus patients in the low-latitude plateau of China: altitudinal influences

Mood changes at very high altitudes in Pakistan

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